Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Abstract

The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

Pharmaceutical Evaluation of Honokiol and Magnolol on Apoptosis and Migration Inhibition in Human Bladder Cancer Cells

“…Despite in vitro findings showing the anti-proliferative and anti-invasive effects of Hono and Mag, changes in in vivo bioluminescence imaging were too subtle to detect among all groups. The potency of Hono and Mag as adjuvants for chemotherapy has been established in the literature (Arora et al, 2012;Ranaware et al, 2018). As a result, one plausible explanation for our in vivo data could be the absence of common chemotherapeutic agents.…”

Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel

“…Tumorigenic cells can lead to the deregulation of multiple signaling pathways. Hence, compounds that act on multiple targets are required in the deterrence and treatment of cancer malignancies [39][40][41][42]. Various studies show the consecutive activation of major signaling pathways which leads to activation of downstream proteins, and contributes to survival, angiogenesis, and metastasis of cancer cells (illustrated in Figure 2).…”

An Overview of the Potential Antineoplastic Effects of Casticin

“…Cancer is the second-most common cause of death globally, responsible for 9.6 million fatalities in 2018 alone, i.e., one in six deaths, globally [1][2][3][4][5][6]. Approximately 17 million people are diagnosed with cancer every year, of which, 70% of deaths occur in lower-middle-and lower-class income families [1].…”