Targeted metabolomics analysis of bile acids and cell biology studies reveal the critical role of glycodeoxycholic acid in buffalo follicular atresia

Wei, Yaochang; Cheng, Juanru; Luo, Ming; Yang, Sufang; Xing, Qinghua; Cheng, Jiarui; Lv, Jiashun; Yu, Chenqi; Sun, Le; Shi, Deshun; Deng, Yanfei

doi:10.1016/j.jsbmb.2022.106115

Cited by 8 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the biological samples used most frequently for BA analysis, discussed above, other media can also be tested for them. Liver tissue was analyzed in 15 papers [28,63,[89][90][91][92][93][94][95][96][97][98][99][100][101], although only 1 [99] included also dogs in the studied species. Sampling liver is especially difficult and requires highly invasive interaction with the subject sampled.…”

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

“…These studies involved mainly rats and mice, removing the intestinal content after their sacrifice [28,75,90,91,94], or humans were studied using a specific device to remove samples from the duodenal liquid [102]. Furthermore, as well, meconium [103], ovaries [101], saliva, exhausted breath [104], eWAT (epididymal white adipose tissue), muscle, and hypothalamus [95] were special matrices studied for BA content on a case-by-case basis. The sample preparation for BA measurements depends strongly on the choice of matrix and the range of compounds to be analyzed.…”

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

“…BAs are frequently measured from lyophilized feces instead of fresh ones [10,28,52,65,67,83,89,90,94,101,103,109,111,115,116,149,151,[153][154][155][156][157][158], thus expressing the BA concentrations based on the dry weight of the lyophilizate. At the same time, it is important to mention that lyophilization requires special equipment and elongates the sample processing time.…”

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance

Németh,

Sterczer,

Kiss

et al. 2024

Metabolites

View full text Add to dashboard Cite

The comprehensive examination of bile acids is of paramount importance across various fields of health sciences, influencing physiology, microbiology, internal medicine, and pharmacology. While enzymatic reaction-based photometric methods remain fundamental for total BA measurements, there is a burgeoning demand for more sophisticated techniques such as liquid chromatography–tandem mass spectrometry (LC-MS/MS) for comprehensive BA profiling. This evolution reflects a need for nuanced diagnostic assessments in clinical practice. In canines, a BA assessment involves considering factors, such as food composition, transit times, and breed-specific variations. Multiple matrices, including blood, feces, urine, liver tissue, and gallbladder bile, offer insights into BA profiles, yet interpretations remain complex, particularly in fecal analysis due to sampling challenges and breed-specific differences. Despite ongoing efforts, a consensus regarding optimal matrices and diagnostic thresholds remains elusive, highlighting the need for further research. Emphasizing the scarcity of systematic animal studies and underscoring the importance of ap-propriate sampling methodologies, our review advocates for targeted investigations into BA alterations in canine pathology, promising insights into pathomechanisms, early disease detection, and therapeutic avenues.

show abstract

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

Section: Matrices To Be Analyzed For Bile Acid Compositionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance

Németh,

Sterczer,

Kiss

et al. 2024

Metabolites

View full text Add to dashboard Cite

show abstract

“…One of the most widespread approaches using BAs in omics technologies is their spectrum detection comparing to a sample of healthy humans. The use of BAs metabolomics for the assessment of organism health, i.e., liver injury, is not exclusive in recent years [152,[157][158][159][160].…”

Section: The Metabolomics Of Bile Acidsmentioning

confidence: 99%

Bile Acids: Physiological Activity and Perspectives of Using in Clinical and Laboratory Diagnostics

Shansky

Bespyatykh

2022

Molecules

View full text Add to dashboard Cite

Bile acids play a significant role in the digestion of nutrients. In addition, bile acids perform a signaling function through their blood-circulating fraction. They regulate the activity of nuclear and membrane receptors, located in many tissues. The gut microbiota is an important factor influencing the effects of bile acids via enzymatic modification. Depending on the rate of healthy and pathogenic microbiota, a number of bile acids may support lipid and glucose homeostasis as well as shift to more toxic compounds participating in many pathological conditions. Thus, bile acids can be possible biomarkers of human pathology. However, the chemical structure of bile acids is similar and their analysis requires sensitive and specific methods of analysis. In this review, we provide information on the chemical structure and the biosynthesis of bile acids, their regulation, and their physiological role. In addition, the review describes the involvement of bile acids in various diseases of the digestive system, the approaches and challenges in the analysis of bile acids, and the prospects of their use in omics technologies.

show abstract

Gut microbial and metabolic characterization of Atlantic salmon (Salmon salar) challenged with Aeromonas salmonicida

Liu

Xia

et al. 2023

Aquaculture

View full text Add to dashboard Cite

Targeted metabolomics analysis of bile acids and cell biology studies reveal the critical role of glycodeoxycholic acid in buffalo follicular atresia

Cited by 8 publications

References 45 publications

Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance

Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance

Bile Acids: Physiological Activity and Perspectives of Using in Clinical and Laboratory Diagnostics

Gut microbial and metabolic characterization of Atlantic salmon (Salmon salar) challenged with Aeromonas salmonicida

Contact Info

Product

Resources

About