Targeted imaging of brain gliomas using multifunctional Fe3O4/MnO nanoparticles

Li, Shuai; Shao, Chen; Gu, Wei; Wang, Rui; Zhang, Juan; Lai, Junxin; Li, Hansheng; Ye, Ling

doi:10.1039/c5ra01069a

Cited by 20 publications

(16 citation statements)

References 28 publications

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“…48 The r 1 value is over five times higher than commercial Magnevist (4.4 ± 0.3 mM −1 s −1 ), which strongly improves its application in sensitive detection. The r 2 and r 1 values of Fe 3 O 4 /MnO nanoparticles are both higher than those of Fe 3 O 4 and MnO nanoparticles (Tables S2), respectively, [30][31][32]38,40,41,44 indicating the synergistic enhancing property of Fe 3 O 4 /MnO nanoparticle-based dual-mode contrast agents. This is most probably due to the doped MnO clusters, presenting spin parallel arrangements in the same directions as the magnetic fields generated by Fe 3 O 4 nanoparticles.…”

Section: ■ Results and Discussionmentioning

confidence: 96%

“…Hence, the T 1 and T 2 relaxivities can be enhanced synergistically because integration of T 1 and T 2 dual-contrast abilities and the magnetic field directions of both contrast materials are in the same directions in this structure. − However, rare-earth contrast agents occasionally cause nephrogenous systemic fibrosis. , Mn(II) is an attractive option for synthesis of T 1 contrast agents due to its five unpaired electrons and longer electron relaxation times. As a result, manganese oxide nanocrystals are favorable for T 1 -weighted MR imaging, which ensures efficiency and safety in vivo. − Therefore, embedding the manganese oxide component into iron oxide nanoparticles may synergistically improve the T 1 – T 2 dual-contrast abilities for clinical applications with health safety and diagnostic accuracy, in which the magnetic field intensities of MnO and Fe 3 O 4 nanoparticles are enhanced simultaneously (Scheme b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Lu¹,

Dong²,

et al. 2019

Langmuir

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The T 1–T 2 dual-mode contrast agents for magnetic resonance imaging (MRI) can generate self-complementary confirmed T 2 and T 1 images, hence greatly improving the reliability. Facilely synthesizing nanoparticles with the ultrasensitive contrast property remains extremely challenging in nanoscience. Moreover, uncovering the mechanism correlating the signal enhancements and chemical constituents is vital for designing novel efficient synergistically enhanced T 1–T 2 dual-mode MRI nanoprobes. Herein, we report a one-pot facile method to synthesize the superparamagnetic manganese oxide-doped iron oxide (Fe3O4/MnO) nanoparticles for T 1–T 2 dual-mode MR imaging. Under external magnetic field, the local magnetic field intensities of MnO and Fe3O4 could be simultaneously enhanced through embedding MnO into Fe3O4 nanoparticles and hence can cause synergistic T 1 and T 2 contrast enhancements. Moreover, a novel and facile cost-effective method for large-scale synthesis of hydroxyl–polyethylene glycol–phosphonic acid-stabilizing ligands is designed. The facile synthetic method and surface coating strategy of superparamagnetic Fe3O4/MnO nanoparticles offer an idea for the chemical design and preparation of superparamagnetic nanoparticles with ultrasensitive MRI contrast abilities for disease evaluation and treatment.

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Section: ■ Results and Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Lu¹,

Dong²,

et al. 2019

Langmuir

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show abstract

Section: Mrimentioning

confidence: 99%

“…Li et al . synthesized Fe 3 O 4 /MnO hybrid nanoparticles through a step-by-step thermal decomposition method [ 82 ]. As wished, the T 1 -weighted imaging ability of MnO combined with the T 2 -weighted imaging ability of Fe 3 O 4 were both inherited in this nanosystem, with an r 1 value of 5.37 mM −1 s −1 and r 2 value of 203.82 mM −1 s −1 .…”

Section: Mrimentioning

confidence: 99%

Construction of nanomaterials as contrast agents or probes for glioma imaging

Zhao

Peng

et al. 2021

J Nanobiotechnol

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Malignant glioma remains incurable largely due to the aggressive and infiltrative nature, as well as the existence of blood–brain-barrier (BBB). Precise diagnosis of glioma, which aims to accurately delineate the tumor boundary for guiding surgical resection and provide reliable feedback of the therapeutic outcomes, is the critical step for successful treatment. Numerous imaging modalities have been developed for the efficient diagnosis of tumors from structural or functional aspects. However, the presence of BBB largely hampers the entrance of contrast agents (Cas) or probes into the brain, rendering the imaging performance highly compromised. The development of nanomaterials provides promising strategies for constructing nano-sized Cas or probes for accurate imaging of glioma owing to the BBB crossing ability and other unique advantages of nanomaterials, such as high loading capacity and stimuli-responsive properties. In this review, the recent progress of nanomaterials applied in single modal imaging modality and multimodal imaging for a comprehensive diagnosis is thoroughly summarized. Finally, the prospects and challenges are offered with the hope for its better development.

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“…Li and colleagues synthesized Fe 3 O 4 /MnO-Cy5.5-CTX NPs for NIRF and T1-/T2-MR multimodal imaging in vitro and in vivo. The CTX (chlorotoxin) is a glioma ligand 44. Zhang et al designed a highly efficient US/MR/CT multimodal probe (Au@HMSN/Au&MnO) 2.…”

Section: Mno-based Nanoparticles In Tumor Diagnosis and Therapymentioning

confidence: 99%

Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy

Cai¹,

Zhu²,

Zeng³

et al. 2019

IJN

178

118

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Contrast agents (CAs) play a crucial role in high-quality magnetic resonance imaging (MRI) applications. At present, as a result of the Gd-based CAs which are associated with renal fibrosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide nanoparticles, Mn-based CAs which have a good biocompatibility and bright images are considered ideal for MRI. In addition, manganese oxide nanoparticles (MONs, such as MnO, MnO2, Mn3O4, and MnOx) have attracted attention as T1-weighted magnetic resonance CAs due to the short circulation time of Mn(II) ion chelate and the size-controlled circulation time of colloidal nanoparticles. In this review, recent advances in the use of MONs as MRI contrast agents for tumor detection and diagnosis are reported, as are the advances in in vivo toxicity, distribution and tumor microenvironment-responsive enhanced tumor chemotherapy and radiotherapy as well as photothermal and photodynamic therapies.

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Targeted imaging of brain gliomas using multifunctional Fe₃O₄/MnO nanoparticles

Cited by 20 publications

References 28 publications

Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Hydroxyl–PEG–Phosphonic Acid-Stabilized Superparamagnetic Manganese Oxide-Doped Iron Oxide Nanoparticles with Synergistic Effects for Dual-Mode MR Imaging

Construction of nanomaterials as contrast agents or probes for glioma imaging

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

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