&lt;p&gt;Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy&lt;/p&gt;

Cai, Xiaoxia; Zhu, Qingxia; Zeng, Yun; Zeng, Yun; Chen, Xueli; Zhan, Yonghua

doi:10.2147/ijn.s218085

Cited by 171 publications

(100 citation statements)

References 130 publications

(155 reference statements)

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“…The Mn ion has a long electron relaxation time and enables high positive MRI contrast. 25 As a high-Z element, Hf, with high X-ray attenuation, can be used as an efficient X-ray CT contrast agent 26 and RT. 16 Porphyrins and their derivatives have good photophysical properties and have been widely used as photosensitizers for PDT, PTT and PAI.…”

Section: Introductionmentioning

confidence: 99%

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

Bao¹,

Zu²,

Wang³

et al. 2020

IJN

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Background: Recent studies have validated and confirmed the great potential of nanoscale metal-organic framework (NMOF) in the biomedical field, especially in improving the efficiency of cancer diagnosis and therapy. However, most previous studies only utilized either the metal cluster or the organic ligand of the NMOF for cancer treatments and merely reported limited theranostic functions, which may not be optimized. As a highly designable and easily functionalized material, prospective rational design offers a powerful way to extract the maximum benefit from NMOF for cancer theranostic applications. Materials and Methods: A NMOF based on hafnium (Hf) cluster and Mn(III)-porphyrin ligand was rational designed and synthesized as a high-performance multifunctional theranostic agent. The folic acid (FA) was modified on the NMOF surface to enhance the cancer targeting efficacy. The proposed "all-in-one" FA-Hf-Mn-NMOF (fHMNM) was characterized and identified using various analytical techniques. Then, in vitro and in vivo studies were performed to further explore the effects of fHMNM both as the magnetic resonance imaging (MRI)/computed tomography (CT)/photoacoustic imaging (PAI) contrast agent and as the photothermal therapy (PTT)/radiotherapy (RT) agent. Results: A tumour targeting multifunctional fHMNM was successfully synthesized with high performance for MRI/CT/PAI enhancements and image-guided PTT/RT synergistic therapy properties. Compared with the current clinical CT and MR contrast agents, the X-ray attenuation and T 1 relaxation rate of this integrated nanosystem increased 1.7-fold and 3-5-fold, respectively. More importantly, the catalase-like Mn(III)-porphyrin ligand can decompose H 2 O 2 into O 2 in tumour microenvironments to improve the synergistic treatment efficiency of PTT and RT. Significant tumour growth inhibition was achieved in mouse cancer models without obvious damage to the other organs. Conclusion: This work highlights the potential of fHMNM as an easily designable material for biomedical applications, could be an effective tool for in vivo detection and subsequent treatment of tumour.

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Section: Introductionmentioning

confidence: 99%

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

Bao¹,

Zu²,

Wang³

et al. 2020

IJN

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“…Manganese oxide NPs with a hydrodynamic diameter of 13.4 ± 1.6 nm will eventually be discharged through the hepatobiliary pathway as feces or urinary excretion. Polyethylene glycol coating also has a high potential to reduce toxicity with manganese oxide NPs [ 35 ].…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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“…It was found that the acidic environment of tumors substantially promoted the break-up of the carrier and subsequently led to the fast release of the loaded DOX-loaded MnO 2 nanosheets into the tumor, reflecting the in vitro results. Manganese-based oxides have been demonstrated as contrast agents for T1-weighted MRI with the improved biocompatibilities [113][114][115]. As the Mn atoms in MnO 2 nanosheets are coordinated with six oxygen atoms in an octahedral geometry, they do not contribute to the longitudinal or transverse relaxation of the protons in water molecules.…”

Section: Mno 2 Nanosheetsmentioning

confidence: 99%

Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

Raja

Kang

Kim

et al. 2020

Cancers

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As the combination of therapies enhances the performance of biocompatible materials in cancer treatment, theranostic therapies are attracting increasing attention rather than individual approaches. In this review, we describe a variety of two-dimensional (2D) theranostic nanomaterials and their efficacy in ablating tumors. Though many literature reports are available to demonstrate the potential application of 2D nanomaterials, we have reviewed here cancer-treating therapies based on such multifunctional nanomaterials abstracting the content from literature works which explain both the in vitro and in vivo level of applications. In addition, we have included a discussion about the future direction of 2D nanomaterials in the field of theranostic cancer treatment.

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<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

Cited by 171 publications

References 130 publications

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

<p>Multifunctional Hf/Mn-TCPP Metal-Organic Framework Nanoparticles for Triple-Modality Imaging-Guided PTT/RT Synergistic Cancer Therapy</p>

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives

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