Target-inspired Pb2+-dependent DNAzyme for ultrasensitive electrochemical sensor based on MoS2-AuPt nanocomposites and hemin/G-quadruplex DNAzyme as signal amplifier

Ji, Renyue; Niu, Wuceng; Chen, Shuai; Xu, Wei; Ji, Xingduo; Yuan, Lingyue; Zhao, Hangyu; Geng, Minghao; Qiu, Jingfu; Li, Chaorui

doi:10.1016/j.bios.2019.111560

Cited by 46 publications

(15 citation statements)

References 41 publications

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“…The binding molecule needs to be modified, few choices of binding molecules [28,29] noble metal nanoparticles -mediated simple, facile, stable, wide variety of binding molecules, properties enhanced complicated preparation process [30][31][32][33][34][35][36]…”

Section: Chemical Interaction Stablementioning

confidence: 99%

“…Due to the synergistic effect of two amplification strategies, the developed electrochemical sensor can determine 29.57 fM Sul1 gene with high selectivity [ 47 ]. Similarly, Ji et al designed an electrochemical sensor for Pb 2+ analysis based on a MoS 2 -based nanoprobe and hemin/G-quadruplex DNAzyme [ 33 ]. The specificity of a DNAzyme combined with the high conductivity of MoS 2 -AuPt nanocomposites means this sensor has a lower detection limit for Pb 2+ analysis (38 fg mL −1 ).…”

Section: Mos 2 -Based Nanoprobes For Sensing Appli...mentioning

confidence: 99%

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Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

et al. 2022

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The use of nanoprobes in sensors is a popular way to amplify their analytical performance. Coupled with two-dimensional nanomaterials, nanoprobes have been widely used to construct fluorescence, electrochemical, electrochemiluminescence (ECL), colorimetric, surface enhanced Raman scattering (SERS) and surface plasmon resonance (SPR) sensors for target molecules’ detection due to their extraordinary signal amplification effect. The MoS2 nanosheet is an emerging layered nanomaterial with excellent chemical and physical properties, which has been considered as an ideal supporting substrate to design nanoprobes for the construction of sensors. Herein, the development and application of molybdenum disulfide (MoS2)-based nanoprobes is reviewed. First, the preparation principle of MoS2-based nanoprobes was introduced. Second, the sensing application of MoS2-based nanoprobes was summarized. Finally, the prospect and challenge of MoS2-based nanoprobes in future were discussed.

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Section: Chemical Interaction Stablementioning

confidence: 99%

Section: Mos 2 -Based Nanoprobes For Sensing Appli...mentioning

confidence: 99%

Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

et al. 2022

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“…Lead ions (Pb 2+ ) are highly toxic heavy metal pollutants that are widespread in the water environment. Since lead ions bioaccumulate and have nonbiodegradable properties, even at low concentrations, lead ions may also cause nervous, reproductive, cardiovascular, and other developmental disorders [115]. Figure 3C demonstrates an ultrasensitive fluorescent assay based on an RCA-assisted multisite-strand-displacement-reaction (SDR) signal-amplification strategy [60].…”

Section: Lead (Pb)mentioning

confidence: 99%

Rolling Circle Amplification as an Efficient Analytical Tool for Rapid Detection of Contaminants in Aqueous Environments

Zhang

Cao

et al. 2021

Biosensors

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Environmental contaminants are a global concern, and an effective strategy for remediation is to develop a rapid, on-site, and affordable monitoring method. However, this remains challenging, especially with regard to the detection of various contaminants in complex water environments. The application of molecular methods has recently attracted increasing attention; for example, rolling circle amplification (RCA) is an isothermal enzymatic process in which a short nucleic acid primer is amplified to form a long single-stranded nucleic acid using a circular template and special nucleic acid polymerases. Furthermore, this approach can be further engineered into a device for point-of-need monitoring of environmental pollutants. In this paper, we describe the fundamental principles of RCA and the advantages and disadvantages of RCA assays. Then, we discuss the recently developed RCA-based tools for environmental analysis to determine various targets, including heavy metals, organic small molecules, nucleic acids, peptides, proteins, and even microorganisms in aqueous environments. Finally, we summarize the challenges and outline strategies for the advancement of this technique for application in contaminant monitoring.

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“…As a result of the extraction of ores and the use of fossil fuels, heavy metal ions, as major environmental pollutants, pose serious threats to human life and health. Recent studies have shown that the electrochemical FNA biosensors developed by DNAzyme have high sensitivity and specificity for heavy metal ions, and thus, they have attracted extensive attention in the field of environmental detection [14,[74][75][76]. Tang et al selected 8-17 DNAzyme for the specific detection of Pb 2+ [20].…”

Section: Electrochemical Functional Nucleic-acid Biosensorsmentioning

confidence: 99%

Recent Advances on Functional Nucleic-Acid Biosensors

Zhang

Guo

et al. 2021

Sensors

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In the past few decades, biosensors have been gradually developed for the rapid detection and monitoring of human diseases. Recently, functional nucleic-acid (FNA) biosensors have attracted the attention of scholars due to a series of advantages such as high stability and strong specificity, as well as the significant progress they have made in terms of biomedical applications. However, there are few reports that systematically and comprehensively summarize its working principles, classification and application. In this review, we primarily introduce functional modes of biosensors that combine functional nucleic acids with different signal output modes. In addition, the mechanisms of action of several media of the FNA biosensor are introduced. Finally, the practical application and existing problems of FNA sensors are discussed, and the future development directions and application prospects of functional nucleic acid sensors are prospected.

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Target-inspired Pb2+-dependent DNAzyme for ultrasensitive electrochemical sensor based on MoS2-AuPt nanocomposites and hemin/G-quadruplex DNAzyme as signal amplifier

Cited by 46 publications

References 41 publications

Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

Rolling Circle Amplification as an Efficient Analytical Tool for Rapid Detection of Contaminants in Aqueous Environments

Recent Advances on Functional Nucleic-Acid Biosensors

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