Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

Abstract

The use of nanoprobes in sensors is a popular way to amplify their analytical performance. Coupled with two-dimensional nanomaterials, nanoprobes have been widely used to construct fluorescence, electrochemical, electrochemiluminescence (ECL), colorimetric, surface enhanced Raman scattering (SERS) and surface plasmon resonance (SPR) sensors for target molecules’ detection due to their extraordinary signal amplification effect. The MoS2 nanosheet is an emerging layered nanomaterial with excellent chemical and physical properties, which has been considered as an ideal supporting substrate to design nanoprobes for the construction of sensors. Herein, the development and application of molybdenum disulfide (MoS2)-based nanoprobes is reviewed. First, the preparation principle of MoS2-based nanoprobes was introduced. Second, the sensing application of MoS2-based nanoprobes was summarized. Finally, the prospect and challenge of MoS2-based nanoprobes in future were discussed.

Thin-Film Electrodes Based on Two-Dimensional Nanomaterials for Neural Interfaces

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Recent Advancement of PD-L1 Detection Technologies and Clinical Applications in the Era of Precision Cancer Therapy

“…The improvement of biosensor performance depends on the selection of an electrode material with good conductivity and stability. MoS 2 is a graphene-like layered nanostructure with a large surface area, high electrical conductivity, good stability, and easy functionalization, which shows great potential for application in electrochemical sensors 96 . Du et al developed a novel electrochemical sensor that could specifically recognize PD-L1 expressed by living tumor cells and tissues; the sensor was based on the nanomaterial MoS 2 and used the PD-L1 antibody as a biorecognition molecule (Fig.…”

Recent Progress in Electrochemical Aptasensors: Construction and Application

“…Electrochemical biosensors have been widely applied in many fields including environmental monitoring, food safety, disease diagnosis, agricultural engineering, and even public safety owing to their excellent advantages of high sensitivity, fast analysis speed, simple operation, high reproducibility, long-term stability, ease of miniaturization, and on-site/in situ analysis [1][2][3]. Nowadays, antibody-based bio-molecular recognition events are the general way to construct electrochemical biosensors for the recognition and detection of target molecules.…”

“…In recent years, great advances in electrochemical aptasensors have been achieved. In this review, we are aiming to give a comprehensive overview of the recent progresses in electrochemical aptasensors with some typical examples: (1) to summarize the immobilization methods of the aptamer as the key recognition unit; (2) to cover a variety of target substances for detection applications in different fields; (3) to put insightful comments on various detection strategies with high sensitivity, specificity, and selectivity and give the exploration experiences and underlying experimental regularity. Finally, the opportunities and challenges of electrochemical aptasensors in the future are also discussed, which will be beneficial to clinical applications or commercial transformations of scientific research.…”