Tarennanosides A–H, Eight New Lignan Glucosides from Tarenna attenuata and Their Protective Effect on H₂O₂‐Induced Impairment in PC12 Cells

Abstract

Eight new lignan glucosides, tarennanosides A-H (1-8, resp.), were isolated from the whole plant of Tarenna attenuata, together with three known compounds, fernandoside, (-)-lyoniresinol, and (-)-isolariciresinol. The planar structures of new compounds were elucidated mainly by analysis of physical and spectroscopic data, and the absolute configurations were determined by acid hydrolysis as well as CD spectroscopy. Compounds 1 and 2 exhibited potent antioxidant activities against H2O2-induced impairment in PC12 cells. Preliminary mechanism study by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed that these two compounds could act as radical scavengers.

Isochaihulactone protects PC12 cell against H2O2 induced oxidative stress and exerts the potent anti-aging effects in D-galactose aging mouse model

“…Isochaihulactone (also known as K8) is a lignan compound that was identified in acetone extracts of Nan-Chai-Hu and shows antitumor activity against A549 cells in vitro and in vivo [25,26] . Lignan compounds (eg, sesamin, sesamolin) have been reported to act as neuroprotective agents against oxidative injury and excitotoxicity [27][28][29][30] . Lignans can also inhibit lipopolysaccharide-inducible COX-2 expression in macrophages [31] .…”

A New Flavone C-Glycoside from Clematis rehderiana

“…Since phenolics are characterized by antioxidant activities [ 11 , 12 , 13 , 14 ], two isolates were subjected to antioxidant activity experiments using both the MTT and DPPH assays ( Table 2 and Table 3 ). Compound 1 showed potent activity against H 2 O 2 -induced impairment in PC12 cells within the concentration range tested (0.4 to 50 μM), whereas isoorientin ( 3 ) scavenged DPPH radical strongly, with an IC 50 value of 13.5 μM.…”

Neuroprotective effects of vomifoliol, isolated from Tarenna obtusifolia Merr. (Rubiaceae), against amyloid-beta1-42-treated neuroblastoma SH-SY5Y cells

“…Among the Tarenna species, T. asiatica is an economically important plant used in traditional folk medicine for a variety of conditions, including boils, external ulcers, sores, and wounds (Ramabharathi et al 2014). Several studies on various Tarenna species have described their medicinal properties, such as antimicrobial (Jayasinghe et al 2002;Karthikkumaran et al 2014;Ramabharathi et al 2014), antioxidant (Ramabharathi et al 2014;Yang et al 2007Yang et al , 2009, anti-inflammatory (Amutha et al 2012), and toxicity (Oloro et al 2016) effects. Phytochemical investigation on the Tarenna species revealed the presence of triterpenoids and triterpenoid glycosides (Harinantenaina et al 2019;Zhao et al 2008, 2013), alkaloid (Takayama et al 1992, iridoids and iridoid glycosides (Takeda et al 1976;Yang et al 2006), lignans (Yang et al 2007(Yang et al , 2009, and sesquiterpenes (Salmoun et al 2007).…”