TaqI B1/B2 and -629A/C cholesteryl ester transfer protein (CETP) gene polymorphisms and their association with CETP activity and high-density lipoprotein cholesterol levels in a Tehranian population. Part of the Tehran Lipid and Glucose Study (TLGS)
Abstract:We examined the cholesteryl ester transfer protein (CETP) gene TaqI intron 1 B1/B2 polymorphism and the -629A/C CETP promoter polymorphism in respect to high-density lipoprotein cholesterol (HDL-C) in a healthy Iranian population taken from the Tehran Lipid and Glucose Study (TLGS). The relationship between CETP activity and HDL-C level was also determined along with body mass index, blood pressure and tobacco smoking status. PCR-RFLP used to amplify a segment of the CETP intron 1 TaqI (B2/B1) polymorphism fro… Show more
“…In comparison to B1B1 genotype, B2 hetero and homozygote subjects had respectively 2.26% and 7.36% higher levels of HDL-C. This positive role is in agreement with the results of the two other studies carried in Iran [43,45]. Thompson et al in their meta- analysis study, that covers the results of 92 studies in different ethnic groups with more than 113,000 subjects, have also found a 4.5% increase in HDL-C levels and a 0.9% and 2% decrease in LDL-C and TG levels respectively for each inherited B2 allele[44].…”
Section: Discussionsupporting
confidence: 90%
“…The frequency of the CETP "B2" allele in this study was 46.1% which is higher than the 38.21% previously found by Daneshpour et al[43] in a group of Tehran's residents. However, it is in accordance with the prevalence of 42% that was reported in White and East Asian populations[44].…”
BackgroundLow level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.ObjectivesTo determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.ResultsSerum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.ConclusionThis study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.
“…In comparison to B1B1 genotype, B2 hetero and homozygote subjects had respectively 2.26% and 7.36% higher levels of HDL-C. This positive role is in agreement with the results of the two other studies carried in Iran [43,45]. Thompson et al in their meta- analysis study, that covers the results of 92 studies in different ethnic groups with more than 113,000 subjects, have also found a 4.5% increase in HDL-C levels and a 0.9% and 2% decrease in LDL-C and TG levels respectively for each inherited B2 allele[44].…”
Section: Discussionsupporting
confidence: 90%
“…The frequency of the CETP "B2" allele in this study was 46.1% which is higher than the 38.21% previously found by Daneshpour et al[43] in a group of Tehran's residents. However, it is in accordance with the prevalence of 42% that was reported in White and East Asian populations[44].…”
BackgroundLow level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.ObjectivesTo determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.ResultsSerum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.ConclusionThis study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.
“…17 These observations are significantly important because low plasma HDL-C levels are associated with an increased risk of cardiovascular disease. Clinical evidence documents that an increase of 1% in the plasma HDL-C levels is associated with a reduction of 2% to 3% in cardiovascular morbidity and mortality.…”
Background: This study was designed to reevaluate the importance of screening for intestinal parasites in elective surgery patients so as to prevent the complications associated with intestinal parasitism in this group of patients.
Methods:The study was carried out in Jos, North Central Nigeria, to determine the prevalence of intestinal parasitism in 130 consecutive elective surgery patients using the direct wet mount and formol ether concentration methods.
“…This could be attributed to industrialization of the country, modification of life style, unhealthy diet, decreased physical activity, and increased prevalence of hypertriacylglycerolmia, obesity and smoking [16]. Association of some genetic factors with low HDL-C levels has been studied in Iranians [30,31]. These results showed that there is a relation between low HDL-C level and some genetic factors.…”
The prevalence of cardiovascular risk factors, especially low level of high density lipoprotein cholesterol (HDL-C), is very high in Iran. The associations of apolipoprotein E (Apo E) polymorphism with lipid profile, especially high density lipoprotein (HDL) subfractions, were examined in Iranian population. A cross-sectional study of 1030 subjects (452 men and 578 women) from the Tehran Lipid and Glucose Study (TLGS) was performed. Serum triacylglycerol, cholesterol, FBS, HDL-C levels and its subfractions, Apo B and Apo A1 were determined and body mass index and blood pressure were measured. A segment of the mentioned gene was amplified by PCR and the polymorphisms were revealed by RFLP using HhaI restriction enzyme. Allele frequencies obtained for APOE Ã 2, APOE Ã 3, and APOE Ã 4 were 5.77, 85.92, and 8.3%, respectively. The presence of the e2 allele was significantly associated with increased serum HDL-C levels and its subfractions both in men and women except HDL3 in men. The LDL/HDL ratio was significantly lower in female. The relations were significant even after adjustment for age, sex, and BMI but hypertension, smoking, and diabetes status decreased the effect of Apo E2 on HDL-C and HDL subfractions. The observed genotype and allele frequencies were similar to those reported for other Caucasians samples. Apo E2 increased the level of HDL-C, HDL subfractions, and decreased the LDL/HDL ratio. These findings highlight the important effect of variation in this gene on lipid levels.
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