Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study

Abstract

BackgroundLow level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.ObjectivesTo determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.ResultsSerum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.ConclusionThis study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.

Association of Hepatic Lipase Gene Polymorphisms with Hypertriglyceridemia and Low High-Density Lipoprotein-Cholesterol Levels Among South Indian Subjects Without Diabetes

“…34 Because HL catalyzes the hydrolysis of TG from intermediate-density lipoprotein and LDL, 35 such defects in the HL gene due to the promoter variant -480 C/T may lead to hypertriglyceridemia. Studies on an interactive effect between HL (also known as LIPC [lipase, hepatic]) gene variants and apolipoprotein E2 and that included C-514T,G-250A variants showed strong association of the TT genotype of the -514 C/T variant with hypertriglyceridemia among healthy Canadian adults 36 and similar association with serum triglycerides among an Iranian population, 37 strengthening the finding among NGT subjects in the present study. Although a few studies have shown quite a significant association with HDL-C in other ethnic populations, 38-40 the present study did not find any association with HDL-C.…”

Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

“…This trend of association was consistent in all ethnic groups and genders although statistical significance was attained only in the Chinese men. Significant association of the B2 allele with elevated HDL-C was also reported for the Framingham population [11], Chinese population [23], Iranian population [19,20] and Tunisian population [9]. In their studies, the protective effects of the B2 allele on the development of CAD were observed in association with increased HDL-C and decreased CETP activity.…”

CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population

“…Moreover, a meta-analysis, based on the data from year 1970 to 2008, also found that individuals with TaqIB B2 allele had higher mean HDL-C concentrations and lower mean CETP activity compared with carriers of B1 allele [13]. Besides, the relationship between TaqIB polymorphism and HDL-C levels was also confirmed by other studies [18,19]. But the association between CETP TaqIB and CAD risk lacks consistency.…”