Tantalum Dissolution Rate in Simulant Lung Fluid

Lima, C.; Coelho, Maysa Joppert; Dalia, Kely C.; Leite, C. V. Barros; Medeiros, G.; Cunha, K. Dias da

doi:10.1007/s11270-007-9471-4

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Here we have focused on galena (PbS) as it is the primary form of lead associated with mining waste. 31 Mining represents an important study area with fine particles identified in processing plants, 32,33 chat piles, 30 and haul road dust; 34 aerosols in close proximity to a Pb smelter (Z ˇerjav, Slovenia) have shown to contain a median particle size distribution of 0.41 mm (unpublished results). PbS is known to be extremely insoluble with a solubility constant (K sp ) of 3.4 Â 10 À28 , a feature emphasized by its approximate 5% bioaccessibility within the gastrointestinal tract (GI tract) defined by both in vitro 35,36 and in vivo 37 experiments.…”

Section: Introductionmentioning

confidence: 99%

Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test

Beeston

Elteren

Šelih

et al. 2010

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A new method is presented for the preparation, characterization and use of PbS (galena) nanoparticles within an in vitro bioaccessibility test representing the respiratory tract, specifically the conditions occurring in conjunction with phagocytosis by cells using artificial lysosomal fluid. Particle production through nanosecond laser ablation enables their rapid production with a relatively narrow particle size distribution, and a diameter enabling them to represent particles that can enter the alveolar region of the respiratory tract (<3 microm). The PbS nanoparticles were characterized by cascade impaction to define their particle size distribution and through the use of X-ray diffraction (XRD) and electron microprobe analysis (EMPA) to define their mineralogy and homogeneity respectively. The particles were collected via liquid impingement in artificial lysosomal fluid and the undissolved material was separated via ultrafiltration after a contact time of 7-140 hours to define the bioaccessibility. The particles produced by the laser ablation of PbS have a homogenous composition and are 0.083-0.75 microm in diameter, spherical, crystalline, and have the same stoichiometry as the target material. Despite the low solubility constant of PbS in water (K(sp) = 3.4 x 10(-28)), 53% +/- 2.25 (SD) (n = 3) of the Pb was leached after ca. 48 hours, at which point equilibrium is reached. The competing effects of citrate and tartrate in the artificial lysosomal fluid are responsible for this high level of bioaccessibility. Nanoparticles of PbS display a level of bioaccessibility within human lungs that suggests they represent a significant risk to human health through the inhalation pathway as a result of phagocytosis, although this needs to be supported by in vivo tests.

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Section: Introductionmentioning

confidence: 99%

Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test

Beeston

Elteren

Šelih

et al. 2010

Analyst

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Study of worker’s exposure to Tantalum-bearing particles in a mining and metallurgical plant

Cunha

Pereira

Guimarães

et al. 2016

Environ Geochem Health

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The objective of this study was to assess worker exposure to mineral dust particles, and a metabolic model, based on the model adopted by ICRP, was applied to assess human exposure to Ta, and predicted values of Ta concentrations in excreta. The occupational exposure to Th, U, Nb, and Ta-bearing particles during routine tasks to obtain Fe-Nb alloys was estimated using air samplers and excreta samples. Ta concentrations in food samples and in drinking water were also determined. The results support that workers were occupationally exposed to Ta-bearing particles, and also indicate that a source of Ta exposure for both workers and the control group was the ingestion of drinking water containing soluble compounds of Ta. Therefore, some Ta compounds should be considered soluble compounds in gastrointestinal tract. Consequently, the metabolic model based on ICRP metabolic model and/or the transfer factor f for Ta should be reviewed and the solubility of Ta compounds in gastrointestinal should be determined.

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Tantalum Dissolution Rate in Simulant Lung Fluid

Cited by 2 publications

References 29 publications

Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test

Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test

Study of worker’s exposure to Tantalum-bearing particles in a mining and metallurgical plant

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