Tanshinone IIA protects against pulmonary arterial hypertension in broilers

Abstract

This investigation was conducted to study the effects of tanshinone IIA (TIIA) on pulmonary arterial hypertension (PAH) in broilers. Two-hundred newly hatched Arbor Acre commercial broilers were randomly divided into 3 groups. All groups, with the exception of the control group (tap water), were given NaCl water (0.3%) starting on the d 15, and broilers in the protected group were fed a diet supplemented with TIIA (2.5 g/kg) starting on the d 15. On d 28, 35, 42, and 49, the ratio of the right ventricular weight to the total ventricular weight (RV: TV) and the values of other biochemical indicators for each group chickens were determined. The concentrations of interleukin-6 (IL-6), interleukin-1β (IL-1β), nuclear factor kappa (NF-κB), and P38 (a mitogen-activated protein kinase) were measured using enzyme-linked immune sorbent assays (ELISA). The results showed that the proportion of chickens in the diseased group with an RV:TV ratio in the range of 0.250 to 0.299 (10%) was significantly higher (25 to 30%) compared to that of the other groups (P < 0.05), and the proportion in all chickens was 28%. In addition, the IL-6, IL-1β, NF-κB, and P38 protein concentrations were higher in the diseased group, whereas there were no differences between the control group and the protected group. Moreover, the measurements of body weight, liver function, kidney function and electrolytes showed significant differences between the diseased group and the other groups. These findings suggest that tanshinone IIA may protect broilers from PAH, which is an important piece of information for the poultry industry.

Effect of Salvia miltiorrhiza aerial parts on growth performance, nutrient digestibility, and digestive enzymes in rabbits

“…aerial parts at the three doses did not cause differences in ADFI and ADG of rabbits among treatments. Literature showed that tanshinone IIA increased ADG of broilers with pulmonary arterial hypertension [ 14 ]; Salvia root improved egg performance of hens [ 15 ]; however, salvianolic acid B prevented ADG in high-fat diet-induced obese mice [ 16 ]. These inconsistencies in feed consumption and growth by feeding aerial parts, root, or bioactive compounds of S.m .…”

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

“…The activation of NF-κB exacerbates PH progression, and the inhibition of NF-κB reduces pulmonary artery occlusion [ 106 ]. A variety of natural products, such as TIIA, MLB, resveratrol, puerarin, betaine, baicalin, and baicalein, can treat PH by inhibiting NF-κB-related pathways [ 45 , 60 , 69 , 72 , 79 , 107 , 108 , 109 ]. In addition, NF-κB activation has been shown to increase MCP-1 expression and promote PASMCs proliferation.…”

Pathogenesis and Prevention of Ascites Syndrome in Broilers

“…Tanshinone is a kind of traditional Chinese medicine with wide clinical application, belonging to Lamiaceae, and it was first recorded in the classic Chinese medical book "Shen Nong Baicao Jing", and it was called "abandoned horse grass"; in "Compendium of Materia Medica" (Hu et al 2017). The active substances in Salvia miltiorrhiza are mainly divided into two categories: fat-soluble and water-soluble.…”