Tannins in Artemisia: the hidden treasure of prophylaxis

Lutgen, Pierre

doi:10.15406/ppij.2018.06.00173

Cited by 16 publications

(18 citation statements)

References 63 publications

(47 reference statements)

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“…Lutgen's research showed that tannin binded to a special protein in P. falciparum and caused morphological changes, physiology, and function of the host's cells which interrupted the development of the parasite. Tannin can reduce the motility of Pseudomonas aeruginosa and lowering the population of protozoa in the stomach of ruminate animals (Lutgen, 2018). Gallic acid also had an antimalarial activity for its interaction with dihydrofolate reductase (DHFR) enzyme in P. falciparum and inhibited that enzyme based on docking visualization with in silico (Arsianti et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effect of Active Substances of Lollyfish (Holothuria atra) Against the Development of Plasmodium falciparum Based on In Silico Study

2020

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The high level of artemisinin resistance as the antimalarial drug makes the active substances found of lollyfish (Holothuria atra) become a very useful discovery as a new antimalarial drug. The purpose of this research is to find out the inhibitory effect of the active substances of lollyfish against the development of Plasmodium falciparum with in silico method. This is a one-shot experimental study research. Based on the test of potentially active substances of lollyfish through PubChem (https://pubchem.ncbi.nlm.nih.gov/), there are pyrogallol and catechin that have potential as the antimalarial drug. Pyrogallol, chlorogenic acid, catechin dan ascorbic acid have indirect inhibition to P. falciparum Orotidine 5-Monophosphate Decarboxylase (PfOMPDC) through carbon dioxide (CO2) and it is visualized by STITCH DB Version 5.0 (http://stitch.embl.de/). The binding affinity score of catechin, obtained from molecular docking, is higher than other substances and artemisinin. The Physicochemical and pharmacokinetic activity of the substance was predicted through SWISS ADME (http://www.swissadme.ch/index.php), while the toxicity was predicted through Pro-Tox (http://tox.charite.de/protox_II/). Catechin is a substance in lollyfish that is the safest because its lowest toxicity and very effective to be used as the antimalarial drug because of its high lethal dose 50 (LD50). Therefore, active substances in lollyfish have inhibitory effects against the development of P. falciparum based on in silico study.

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Section: Resultsmentioning

confidence: 99%

Inhibitory Effect of Active Substances of Lollyfish (Holothuria atra) Against the Development of Plasmodium falciparum Based on In Silico Study

2020

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“…In addition, anthraquinones emodin, flavonoid glycosides and aglycone demonstrated pronounced therapeutic effects on inflammatory bowel syndrome and significantly inhibit related adverse conditions such as gastrointestinal pain and bloody diarrhoea [60]. Also, tannin-rich S. media extract exhibited strong prophylaxis potential and also displayed significant antimalarial activity [61].…”

Section: Discussionmentioning

confidence: 99%

Stellaria media (L.) Vill.- A plant with immense therapeutic potentials: phytochemistry and pharmacology

Oladeji

Oyebamiji

2020

Heliyon

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Stellaria media Vill. is a representative of Caryophyllaceae family. The plant is widely dispersed all over the world and has been used as therapeutic substance since time immemorial. This review is aimed at exploring the chemical constituents and pharmacological activities of S. media. The findings revealed important secondary metabolites such as flavonoid, oligosaccharide stellariose, anthraquinone derivatives, fatty acid, steroid saponins and phenolic compounds. These bioactive metabolites displayed diverse pharmacological activities such as antiobesity, antifungal, antibacterial, antioxidant, anti-proliferative, anti-inflammatory, analgesic, antidiabetic and anxiolytic activities. All findings revealed that S. media is a major species of Caryophyllaceae family. However, bioactive constituents and pharmacological potential of are not well appraised. Hence, extracts with established pharmacological activities should be subjected to bioassay guided isolation so as to obtain compounds with novel structural moieties prior to toxicogenetic appraisals.

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“…Tannins are naturally occurring polyphenol compounds that form complexes with proteins (Singh et al, 2012). As reported Lutgen (2018), the content of tannins in different organs of various species of Artemisia from Turkey, Iran, Algeria varied but leaves of A. annua had a higher content of tannins in approximately 10 times. Singh et al (2012) determined the content of tannins expressed on gallic acid equivalent to 30.44 mg/g in the water extract.…”

Section: Figurementioning

confidence: 86%

“…Among 600 phytochemicals identified in A. annua, the most dominated are sesquiterpenes, flavonoids, and coumarins (Isani et al, 2019). Some reviews demonstrated the antioxidant activity of A. annua but A. ludoviciana had a higher value of this parameter (Lutgen, 2018). Also, the antimicrobial activity of A. abrotanum described against gram-positive and gram-negative bacteria and Candida albicans (Ivashchenko et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Some Biochemical Parameters of Raw of Artemisia Spp. (Asteraceae Bercht. & J. Presl.)

Korablova¹,

Vergun

Fishchenko³

et al. 2020

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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This study was aimed to investigate the biochemical composition of plant raw material of Artemisia spp. in conditions of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (Kyiv) at both budding and flowering stages. It was investigated the following species of Artemisia L. genus: A. abrotanum L., A. annua L., A. argyi H. Lev. & Vaniot, A. austriaca Jacq., A. japonica Thunb., A. ludoviciana Nutt., and A. maritima L. The content of dry matter determined by measuring till constant weight, the total content of reducing sugars by Bertrand method, tannins with indigo carmine, titratable acidity by titration with sodium hydroxide, and ascorbic acid with 2.6-dichlorophenol-indophenol, and the content of carotene on spectrophotometer with Kalosh petrol. At the stage of budding content of dry matter was from 26.72 (A. annua) to 48.63 (A. maritima) %, the content of reducing sugars from 5.11 (A. austriaca) to 8.93 (A. maritima) %, the titratable acidity from 2.06 (A. abrotanum) to 3.52 (A. japonica), the tannin content from 2.77 (A. abrotanum) to 5.1 (A. ludoviciana) %, ascorbic acid content from 11.65 (A. argyi) to 37.68 (A. japonica) mg%, and the content of carotene from 0.09 (A. ludoviciana) to 0.56 (A. abrotanum) mg%. At the stage of flowering, dry matter in raw was from 31.64 (A. annua) to 42.74 (A. austriaca) %, the content of sugars from 6.8 (A. austriaca) to 8.23 (A. annua) %, titratable acidity from 2.8 (A. abrotanum) to 4.66 (A. annua) %, tannin content from 4.22 (A. austriaca) to 6.36 (A. annua) %, the ascorbic acid content from 12.93 (A. abrotanum) to 65.18 (A. annua) mg%, and carotene content from 0.14 (A. austriaca) to 0.22 (A. annua) mg%. Also, at the period of budding very strong correlation was between titratable acidity and tannin content (r = 0.824), moderate correlation between dry matter and sugars content (r = 0.581). At the stage of flowering determined a very strong correlation between sugars and tannin content (r = 0.890), titratable acidity and tannins (r = 0.957), titratable acidity and ascorbic acid content (r = 0.999), tannins and ascorbic acid content (r = 0.966). In the M.M. Gryshko National Botanical Garden of the NAS of Ukraine just plants of A. abrotanum, A. annua, and A. austriaca passed in the period of flowering. Obtained data can be used for the deep further biochemical and pharmacological study.

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Tannins in Artemisia: the hidden treasure of prophylaxis

Cited by 16 publications

References 63 publications

Inhibitory Effect of Active Substances of Lollyfish (Holothuria atra) Against the Development of Plasmodium falciparum Based on In Silico Study

Inhibitory Effect of Active Substances of Lollyfish (Holothuria atra) Against the Development of Plasmodium falciparum Based on In Silico Study

Stellaria media (L.) Vill.- A plant with immense therapeutic potentials: phytochemistry and pharmacology

Evaluation of Some Biochemical Parameters of Raw of Artemisia Spp. (Asteraceae Bercht. & J. Presl.)

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