Stellaria media (L.) Vill.- A plant with immense therapeutic potentials: phytochemistry and pharmacology

Abstract

Stellaria media Vill. is a representative of Caryophyllaceae family. The plant is widely dispersed all over the world and has been used as therapeutic substance since time immemorial. This review is aimed at exploring the chemical constituents and pharmacological activities of S. media. The findings revealed important secondary metabolites such as flavonoid, oligosaccharide stellariose, anthraquinone derivatives, fatty acid, steroid saponins and phenolic compounds. These bioactive metabolites displayed diverse pharmacological activities such as antiobesity, antifungal, antibacterial, antioxidant, anti-proliferative, anti-inflammatory, analgesic, antidiabetic and anxiolytic activities. All findings revealed that S. media is a major species of Caryophyllaceae family. However, bioactive constituents and pharmacological potential of are not well appraised. Hence, extracts with established pharmacological activities should be subjected to bioassay guided isolation so as to obtain compounds with novel structural moieties prior to toxicogenetic appraisals.

Evaluation of In Vitro Wound-Healing Potential, Antioxidant Capacity, and Antimicrobial Activity of Stellaria media (L.) Vill

“…The results obtained in terms of content in bioactive compounds and antioxidant capacity are in accordance with data from the literature [8,14,21]. Table 3 shows the bioactive compounds identified in SM that contribute to the antioxidant, antimicrobial, and skin-repairing effects.…”

“…The peak from around 0.450 V can be attributed to ascorbic acid oxidation, leading to a content of 0.47 ± 0.003 µg/mL. The value of AEAC was 26 ± 0.02 µg/mL, which indicates an important antioxidant capacity of SM extract, in accordance with other studies employing spectrophotometric methods [14][15][16][17].…”

“…The SM plant has antioxidant properties based on its phytochemical composition, as pointed out by Oladeji et al, 2020, which states that the SM extract exhibited a high-level antioxidant capacity (76% for DPPH and 79% for FRAP) [14].…”

Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance

“… 32 In the literature, there are some experimental data suggesting similar antioxidant and anti-inflammatory properties of Stellaria media , which can be associated with the improvement of certain cardiac parameters in our present study. 35 Therefore, we tested the in vitro antioxidant capacity of Stellaria media tea, and we found a low antioxidant activity. This phenomenon was observed by another study too, where the antioxidant activity of the aqueous and methanolic extract was weak.…”

“…phenolic compounds, flavonoids or steroid saponins, that may play a role in pharmacological activities. 35 We determined the total flavonoid content of Stellaria media tea and it was 9.88 ± 0.10 mg QE/g. The flavonoid content of Stellaria media has been discussed by several papers.…”