Tannic acid as a topical agent in burns: historical considerations and implications for new developments

Hupkens, Pieter; Boxma, H.; Dokter, J.

doi:10.1016/0305-4179(95)90784-w

Cited by 53 publications

(37 citation statements)

References 20 publications

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“…They have an important astringent action, which increases the number of cross-links among collagen fibers in the collagen-rich matrix (tanning) (van Gulik, 1981; Haslam, 1998). In lesions caused by burns, tannins coagulate lipid-protein complexes and accelerate the formation of a flexible scab that covers the wound (Hupkens et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Hernandes

Pereira

Palazzo

et al. 2010

Braz. J. Pharm. Sci.

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This study evaluated the cicatrizant effect of an ointment containing 1% of the ethyl-acetate fraction extracted from the stem bark of "barbatimão" (Stryphnodendron adstringens), in wounds made in the skin of rats, after 4, 7 and 10 days of treatment. Control wounds were treated with a base ointment without extract. The proliferation of keratinocytes in the area of reepithelialization was evaluated by counting the number of epithelial cells that were blocked in metaphase by vincristine sulfate. The length of the reepithelialized margin and the contraction of the wound were measured. Topical application of the "barbatimão" ointment stimulated proliferation of the keratinocytes, but had no effect on the length of the epithelium or on the contraction of the wounds. Uniterms:Stryphnodendron adstringens/pharmacognosy. Stryphnodendron adstringens/ cicatrizant effect. "Barbatimão"/pharmacognosy. Wound/healing/experimental study. Reepithelialization.Neste estudo, avaliou-se a atividade cicatrizante de uma pomada contendo uma fração acetato de etila 1% obtida de cascas de "barbatimão" (Stryphnodendron adstringens) em feridas excisionais na pele de ratos após 4, 7 e 10 dias de tratamento. Feridas controle foram tratadas com pomada base, sem extrato. A proliferação dos queratinócitos na área reepitelizada foi avaliada através da contagem do número de queratinócitos bloqueados em metáfase, pelo sulfato de vincristina. O comprimento da margem reepitelizada e a contração das feridas foram mensurados. As feridas tratadas com barbatimão apresentaram um maior número de mitoses do que aquelas tratadas com a pomada base, em todos os tempos avaliados. A aplicação tópica da pomada de "barbatimão" estimulou a proliferação epitelial contudo não teve efeito sobre a migração dos queratinócitos ou sobre a contração das feridas. Unitermos:Stryphnodendron adstringens/farmacognosia. Stryphnodendron adstringens/efeito cicatrizante. "Barbatimão"/farmacognosia. Feridas/cicatrização/estudo experimental. Reepitelização. INTRODUCTIONIn cutaneous lesions, tannins bind to the proteins of the injured tissues, precipitating them (Fernandez et al., 2002) and creating a protective layer (Neto et al., 1996). This layer isolates the wound site from the environment, reducing the permeability and exudation of the wound (Brown, Dattner, 1998;Bedi, Shenefelt, 2002) and promoting tissue repair. Tannins also exhibit vasoconstrictor and anti-inflammatory properties (Mota et al., 1985;Kapu et al., 2001) and stimulate the growth of epidermis, aiding reepithelialization (Palermo et al., 2002;. Reepithelialization involves the proliferation and migration of cells from the edges of the wound, and is regulated by mechanisms involving genes, growth factors, integrins, extracellular matrices (ECM) and metalloproteinases (MMPs) (Santoro, Gaudino, 2005).Stryphnodendron Martius, Leguminosae, popularly known as "barbatimão", is a Brazilian savannah tree. Extracts of the stem bark from species of Stryphnodendron have several medically useful properties, such as antiinflamma...

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Section: Resultsmentioning

confidence: 99%

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Hernandes

Pereira

Palazzo

et al. 2010

Braz. J. Pharm. Sci.

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“…Once again the earlier report confirmed that Proanthocyanidins or condensed tannins are a group of biologically active Polyphenolic bioflavonoids that are synthesized by many plants. Proanthocyanidins and other tannins are known to facilitate wound healing 25,26 . Tannins promote wound healing through several cellular mechanisms: scavenging of free radicals and reactive oxygen species, promoting contraction of the wound and increasing the formation of capillary vessels and fibroblasts 27 .…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Activity of Various Extracts of Fruit of Pyrus Communis L. In Normal Rats

Chinnasamy¹,

Bhargava²

2014

J Pharm Sci Innov.

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To evaluate the fruit of Pyrus communis L. for its wound healing property by different wound models using wistar albino rats. The wound healing activity of ethyl acetateandethanol extracts of fruits of Pyrus communis (EAEPC and EEPC 200 mg/kg) was investigated by various wound healing model in normal rats such as excision, incision and dead space wound model. Povidone iodine is used as standard. The wound was created according to standard procedure in different model and the wound contraction area, epithelization period, scar area, breaking strength and weight of granulomawere assessed. The phytochemical screening and total phenolic content was estimated in both extracts. Hydroxyproline content of harvested granulation tissue was estimated in all groups of animals. The result suggests various extracts of Pyrus communis have significant (p < 0.01) wound healing activity in different models. In this study we concluded that fruit of Pyrus communis is natural remedy for treating different type of wounds.

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“…Historically, TA was used as a standard topical treatment of burns [24] but this practice was relatively short-lived due to suspected issues of hepatotoxicity. Since Gall is the suspected culprit [8], this toxicity is likely attributable to poor TA purity (particularly in older preparations of TA) and/or the instability of TA.…”

Section: Article In Pressmentioning

confidence: 99%

Structural requirements for stabilization of vascular elastin by polyphenolic tannins

et al. 2006

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Tannic acid as a topical agent in burns: historical considerations and implications for new developments

Cited by 53 publications

References 20 publications

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Wound-healing evaluation of ointment from Stryphnodendron adstringens (barbatimão) in rat skin

Wound Healing Activity of Various Extracts of Fruit of Pyrus Communis L. In Normal Rats

Structural requirements for stabilization of vascular elastin by polyphenolic tannins

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