2013
DOI: 10.1155/2013/280496
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Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis byTaenia solium

Abstract: Human neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T. solium adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans. Tamoxifen is an antiestrogenic drug with cysticidal action on Taenia crassiceps, a close relative of T. solium. Thus, we evaluated the effect of tamoxifen on … Show more

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Cited by 14 publications
(15 citation statements)
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“…As was mentioned previously, TAM induces protection against the in vivo establishment of T. solium and T. crassiceps (12,13). Although the conditions used in our experiments are different, since E. granulosus is a tissue parasite, our results coincide.…”
Section: Discussionsupporting
confidence: 82%
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“…As was mentioned previously, TAM induces protection against the in vivo establishment of T. solium and T. crassiceps (12,13). Although the conditions used in our experiments are different, since E. granulosus is a tissue parasite, our results coincide.…”
Section: Discussionsupporting
confidence: 82%
“…Recent evidence revealed that estrogens can affect Taenia physiology (13,36). Within this line of evidence, the efficiency of chemoprotective TAM treatment suggests a possible role for the estrogens in Echinococcus development.…”
Section: Discussionmentioning
confidence: 98%
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“…A follow-up study showed that tamoxifen decreased the intestinal establishment of T. solium in hamsters by approximately 70%. Moreover, tamoxifen induced morphological changes: the recovered tapeworms appeared like scolices without strobilar development and consequently showed an 80% reduction in length ( Escobedo et al, 2013 ). Yet the taenicidal and cysticidal potential of tamoxifen has not been evaluated in humans and livestock.…”
Section: Cestode Infectionsmentioning
confidence: 99%