Repurposing drugs for the treatment and control of helminth infections

Panić, Gordana; Duthaler, Urs; Speich, Benjamin; Keiser, Jennifer

doi:10.1016/j.ijpddr.2014.07.002

Cited by 163 publications

(129 citation statements)

References 225 publications

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“…18 Artesunate appears to be the most promising candidate as broadspectrum drug for its non-toxic nature, stability and solubility. 19,20 The effectiveness of artesunate on trematodes is well established. The worm burden of small intestinal trematodes, heterophyids, in mice was reduced by 100 % after three days of routine medication with 200 mg/kg/day of artesunate.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anthelmintic Activity of Artesunate Against the Cestode Raillietina Echinobothrida

Lalchhandama¹

2015

Int. Res. J. Pharm.

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Artesunate is an anti malarial compound discovered from the Chinese medicinal plant Artemisia annua. It has been proven to be the best drug not only in the treatment of malaria, but also of human schistosomiasis. It is also shown to be highly effective against human virus, trematodes and various cancer cells. This study is a further exploration on its pharmacological potential as an anti cestodal agent. The cestode, Raillietina echinobothrida Mégnin, were collected from fowls and treated with varying doses of artesunate, namely 1, 2, 5, 10 and 20 mg/ml. The anthelmintic activity was compared with that of the standard prescription drug albendazole. Artesunate showed higher anthelmintic activity than albendazole. Microscopic examination of the cestodes treated with drugs showed extensive structural damage, including surface erosion and destruction of the scolex. The findings suggest that artesunate is a potent drug that may be used for cestode infection.

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Section: Discussionmentioning

confidence: 99%

In Vitro Anthelmintic Activity of Artesunate Against the Cestode Raillietina Echinobothrida

Lalchhandama¹

2015

Int. Res. J. Pharm.

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“…ISSN 1411-2027 poor hygiene. In connection with the countermeasures to this kind of infection, various synthetic drug has long been used especially to tackle problems in mammalian livestock, on the other hand it is also well known that certain drug residue can be very harmful for the animal production consumer (Panic et al, 2014). To date, very limited scientific information is available on the benefits natural resource of colostrum IgG in overcoming worm parasite infection (Rumokoy and Toar, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Colostrum Immunoglobulin on Strongyloides Infection in Mice

Rumokoy

Posangi

Turangan

et al. 2016

JAP

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Abstract. This experiment was conducted to determine the effects of bovine colostrum IgG on mice infected with Larvae of Strongyloides venezuelensis (L3Sv). This experiment was a 2X2 factorial arrangement including two level of colostrum immunoglobulin-Gand two level of endostatine. The parameters were fecal eggs and number of female adult in the gut. The data were statistically analyzed for the mean and standard deviation values, and the differences in treatment groups were subject to ANOVA, if the global differences were detected, a post-ANOVA with LSD test ensued. The development of female adult in the gut, for each group, was performed using Spearman's rho test. Results showed that colostrum immunoglobulin-G reduce very significantly (P<0.001) the number of eggs per gram feces than in the groups of infected animals treated with endostatine as well as in the mice injected with 3000 L3Vs only. While the reduction of female larvae was significant obtained (P<0.05) in colostrum treatment (L3Sv + colostrum IgG) in comparison with endostatine. It was concluded that the supplementation of immunogobuline-G through the animal digestive system hadpositively control the Strongyloidesvenezuelensis parasite infection. This result provides aninsight to utilize IgG colostrum in animal husbandry to overcome the threat of parasitic worms infection. Key words:Immunoglobulin-G, colostrum, intestine, parasite, animal husbandry Abstrak: Penelitian ini bertujuan untuk mengkaji pengaruh IgG colostrum terhadap infeksi larva Strongyloidesvenezuelenensis (L3Sv) melalui suatu model eksperimen menggunakan tikus sebagai hewan percobaan. Penelitian ini disusun secara faktorial 2X2 yaitu faktor dua level IgG kolostrum dan dua level endostatine sebagai pembanding. Parameter yang digunakan adalah kuantitas telur cacing fekal dan larva betina parasit dalam usus. Dalam eksperimen ini menggunakan tikus yang semuanya diinjeksi 3000 L3Vs. Data yang diperoleh dianalisis secara statistik untuk rata-rata, standar deviasi dan dilakukan uji perbandingan antar kelompok dengan ANOVA dan dilanjutkan dengan uji LSD. Perkembangan jumlah larva betina dalam usus dari setiap kelompok treatment dianalisis menggunakan uji Spearman rho. Hasil penelitian menunjukkan bahwa immunoglobulin-G (IgG) kolostrum mampu menurunkan secara sangat siknifikan (P<0.001) jumlah telur parasite per gram feces pada hewan percobaan dibandingkan endostatin, maupun hewan yang tidak mendapat perlakuan IgG dan endostatin sama sekali. Penurunan larva pada perlakuan IgG kolostrum berbeda nyata (P<0.05) dibandingkan dengan dua kelompok pembanding lainnya. Dapat disimpulkan bahwa suplementasi IgG kolostrum melalui sistem saluran pencernaan hewan memberi pengaruh positif untuk mengontrol infeksi parasit Strongyloides venezuelensis. Hasil penelitian ini memberi ide untuk menerapkan penggunaan IgG kolostrum dalam peternakan untuk mengatasi ancaman infeksi cacing.

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“…This strategy is based on the use of an already known and/or an approved drug to treat a (completely) different disease. [37] In collaboration with Prof. Christophe Biot and Prof. Jennifer Keiser, we evaluated the potential of the organometallic antimalarial drug candidates discussed above, namely Ferroquine and Ruthenoquine (Fig. 3) as antischistosomal agents.…”

Section: Introductionmentioning

confidence: 99%