Tamoxifen/raloxifene loaded liposomes for oral treatment of breast cancer

Ağardan, N. Başaran Mutlu; Değim, Zelihagül; Yılmaz, Şükran; Altıntaş, Levent; Topal, Turgut

doi:10.1016/j.jddst.2020.101612

Cited by 24 publications

(10 citation statements)

References 51 publications

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“…Liposomes are the nanocarrier, which are small spherical bilayered lipid vesicles, hence allowing the incorporation of both hydrophilic and lipophilic material in their respective compartments [ 9 , 10 ]. Liposomes are promising carriers for delivery of higher drug payloads to target site and prolongs the circulation time in systemic circulation [ 11 , 12 ]. Liposomes have biocompatible and biodegradable properties and most acceptable as drug delivery vehicles.…”

Section: Introductionmentioning

confidence: 99%

QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation

et al. 2021

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Azacitidine (AZA), an inhibitor of DNA methyltransferase, is a commonly recognized drug used in clinical treatment for myelodysplastic syndrome and breast cancer. Due to higher aqueous solubility and negative log P of AZA causes poor cancer cell permeation and controlled release. The objective of the present study was to formulate and optimize AZA-loaded liposome (AZA-LIPO) for breast cancer chemotherapy by using Box Behnken design (BBD) and in vitro evaluation using MCF-7 cells. AZA-LIPO were prepared using a thin film hydration technique and characterization study was performed by using FTIR and DSC. The prepared formulations were optimized using BBD and the optimized formulation was further subjected for particle size, surface charges, polydispersity index (PDI), drug loading, entrapment efficiency, TEM, XRD, in-vitro drug release and hemolytic toxicity. The mean particle size of optimized AZA-LIPO was 127 nm. Entrapment efficiency and drug loading of AZA-LIPO was found to be 85.2% ± 0.5 and 6.82 ± 1.6%, respectively. Further, in vitro drug release study showed preliminary burst release in 2 h followed by a sustained release for 36 h in phosphate buffer at different pH (4.0, 5.5, and 7.4) as compared to free drug. Drug release was found to be pH dependent, as the pH was increased, the drug release rate was found to be low. Time-dependent cell viability assay exhibited significant higher cell viability and higher internalization than free AZA in MCF-7 cells. AZA-LIPO were more effective than the free AZA in reducing Bcl2 expression, while increasing pro-apoptotic Bax and caspase-3 activity. The result showed that the formulated biocompatible AZA-LIPO nano-formulations may be used as an efficient anti-cancer drug delivery system for the treatment of breast cancer after establishing preclinical and clinical studies.

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Section: Introductionmentioning

confidence: 99%

QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation

et al. 2021

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“…This represented a 50% therapeutic efficacy. 47 The creation of a stable Nanostructured lipid carrier (NLC) technology as a TAM carrier is reported by Rasedeea et al TAM-NLC appears to be a potential drug delivery system for breast cancer therapy, according to the findings. TAM-NLC was tested in vitro against human and animal mammary cancer cell lines.…”

Section: Nano Drug Delivery System Of Tamoxifenmentioning

confidence: 99%

Tamoxifen: An Investigative Review for Nano Dosage Forms and Hyphenated Techniques

Patel

Bhalani

Sudani

et al. 2022

IJPI

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Tamoxifen (TAM), a non-steroidal antiestrogen, has revolutionized female breast cancer treatment. The mechanism involves is to compete with 17β-estradiol (E2) at the receptor site and blocking the promotional role of E2 in breast cancer. Tam is a pioneering medicine because of its widespread usage in breast cancer treatment and chemoprevention, as well as research into novel selective estrogen receptor modulators (SERMs). In the vast majority of patients, TAM is cost-effective, life-saving, and free of significant adverse effects. In this context, this review presents several nanoformulations for selectively delivered lower dosages of TAM to breast tumors. Various TAM-containing nanosystems have been effectively created to deliver TAM to particular molecular targets with decreasing harmful effects. Following that, there is a summary of chromatographic techniques to quantify the drug in human biological samples. The quantification of the drug in different biological matrices is the major importance to assist the control of quality, efficacy, and safety.

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“…. analgesic and anti-inflammatory, 98-105 . anti-inflammatory, 106-109 . anticancer/tumor, [110][111][112][113][114][115][116][117] . antidiabetic, 118-121 . antidiabetic nephropathy, 122…”

Section: Formulation Strategies Of Drugs For Oral Administrationmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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Tamoxifen/raloxifene loaded liposomes for oral treatment of breast cancer

Cited by 24 publications

References 51 publications

QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation

QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation

Tamoxifen: An Investigative Review for Nano Dosage Forms and Hyphenated Techniques

Nano Spray-Dried Drugs for Oral Administration: A Review

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