Tamarind Seed Polysaccharide-g-Poly(N-Vinyl-2-Pyrrolidone): Microwave-Assisted Synthesis, Characterization, and Evaluation as Mucoadhesive Polymer

Ahuja, Munish; Kumar, Sunil; Kumar, Ashok

doi:10.1080/00914037.2012.761624

Cited by 22 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Grafting of TG with polyacrylamide and poly (N-vinyl-2-pyrrolidone) improves properties like matrix forming ability and mucoadhesion respectively [74,75] . Ahuja and Verma, (2014) attempted microwave-assisted synthesis of graft copolymer of carboxymethyl tamarind seed polysaccharide and polyacrylonitrile [76] .…”

Section: Graft-modified Tgmentioning

confidence: 99%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

View full text Add to dashboard Cite

Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

show abstract

Section: Graft-modified Tgmentioning

confidence: 99%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

View full text Add to dashboard Cite

show abstract

“…PAAm has been grafted onto tamarind Xy by microwave-assisted polymerization, and the generated derivative (Xy-g-PAAm) has been used for nanofabricating wound dressings [ 15 ]. In addition, mucoadhesive polymers (Xy-g-poly(n-vinyl pyrrolidone)) [ 16 ] and flocculating agents (Xy-g-polyacrylonitrile) have also been prepared by the above-described method [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of xyloglucan-grafted poly(N-hydroxyethyl acrylamide) copolymer by free-radical polymerization for in vitro evaluation of human dermal fibroblasts

González-Torres,

Martínez-Mata,

Ruvalcaba-Paredes

et al. 2024

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Xyloglucan is a rigid polysaccharide that belongs to the carbohydrate family. This hemicellulose compound has been widely used in biomedical research because of its pseudoplastic, mucoadhesive, mucomimetic, and biocompatibility properties. Xyloglucan is a polyose with no amino groups in its structure, which also limits its range of applications. It is still unknown whether grafting hydrophilic monomers onto xyloglucan can produce derivatives that overcome these shortcomings. This work aimed to prepare the first copolymers in which N-hydroxyethyl acrylamide is grafted onto tamarind xyloglucan by free-radical polymerization. The biocompatibility of these structures in vitro was evaluated using human dermal fibroblasts. Gamma radiation-induced graft polymerization was employed as an initiator by varying the radiation dose from 5–25 kGy. The structure of the graft copolymer, Xy-g-poly(N-hydroxyethyl acrylamide), was verified by thermal analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy. The findings indicate that the degree of grafting and the cytotoxicity/viability of the xyloglucan-based copolymer were independent of dose. Notably, the grafted galactoxyloglucan exhibited efficient support for human dermal fibroblasts, showing heightened proliferative capacity and superior migration capabilities compared to the unmodified polymer. This copolymer might have the potential to be used in skin tissue engineering.

show abstract

“…In another investigation by Ahuja et al, buccal patches of metronidazole using tamarind seed polysaccharide and tamarind seed polysaccharide-g-poly (N-vinyl-2-pyrrolidone) were prepared and evaluated. 101 The ex-vivo bioadhesion study showed bioadhesion time of 9.3 h with > 80% of the drug getting released while the buccal patches using tamarind seed polysaccharide showed ex-vivo bioadhesion time of 5 h releasing 50% of the drug.…”

Section: Buccal Drug Deliverymentioning

confidence: 99%

“…[97][98][99][100][101][102] Nifedipine buccoadhesive tablets of using tamarind seed polysaccharide were formulated and evaluated for buccoadhesive delivery, which have shown a good mucoadhesivity with the goat buccal mucosa and sustained nifedipine releasing behaviour. 97 Moreover, tamarind seed polysaccharide was compared with HPMC and Na CMC as buccoadhesive agents in these tablets.…”

Section: Buccal Drug Deliverymentioning

confidence: 99%

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak¹,

Pal²

2017

IJPER

View full text Add to dashboard Cite

Currently, various plant polysaccharides have been studied for their diverse applications as excipients like binders, granulating agents, disintegrants, emulsifiers, suspending agents, gelling agents, mucoadhesive agents, matrix-formers, release retardants, enteric resistants, etc., in various pharmaceutical dosage forms. Among these, tamarind seed polysaccharide is an emerging excipient, which is beingused and investigated for the preparation of various dosage forms like suspensions, emulsions, tablets, gels, creams, beads, spheroids, microparticles, nanoparticles, ophthalmic preparations, and buccal patches, etc. The current chapter deals with a comprehensive and useful discussion on pharmaceutical applications of tamarind seed polysaccharide withits some important features like source, isolation, chemical composition and properties.

show abstract

Tamarind Seed Polysaccharide-g-Poly(N-Vinyl-2-Pyrrolidone): Microwave-Assisted Synthesis, Characterization, and Evaluation as Mucoadhesive Polymer

Cited by 22 publications

References 19 publications

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Preparation of xyloglucan-grafted poly(N-hydroxyethyl acrylamide) copolymer by free-radical polymerization for in vitro evaluation of human dermal fibroblasts

Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Contact Info

Product

Resources

About