Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Nayak, Amit Kumar; Pal, Dilipkumar

doi:10.5530/ijper.51.2s.60

Cited by 67 publications

(13 citation statements)

References 41 publications

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“…Indian production of tamarind is about 0.3 million tons per year. [15] TG is composed of (1→4)-β-D-glucan backbone substituted with side chains of α-D-xylopyranose and β-D-galactopyranosyl (1→2)-α-Dxylopyranose linked (1→6) to glucose residues. [16] It is noncarcinogenic, non-toxic, biocompatible, and stable at wide range of pH.…”

Section: Research Articlementioning

confidence: 99%

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Mali¹

2018

AJP

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Aim: The objective of this study was to develop and evaluate carboxymethylcellulose (CMC) and tamarind gum (TG)-based citric acid cross-linked vancomycin-loaded hydrogel dressing for wound healing. Materials and Methods: CMC and TG are known for its biocompatibility and biodegradability and hence selected for preparation of hydrogel dressings. The hydrogel films were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid-state 13 C-nuclear magnetic resonance (13 C-NMR) spectroscopy, differential scanning calorimeter (DSC), and scanning electron microscopy (SEM). The prepared hydrogel films were evaluated for the carboxyl content and equilibrium swelling ratio. Vancomycin hydrochloride was loaded into hydrogels films and drug release was studied in the phosphate buffer pH 7.4. The hemolysis assay was used to study the biocompatibility of hydrogel films. The wound healing activity of optimized hydrogel film was studied in the albino mice of either sex. Results and Discussion: The results of ATR-FTIR, solid-state 13 C-NMR, DSC, and SEM confirmed the formation of citric acid cross-linked hydrogel films. The total carboxyl content of hydrogel film was found to be increased when polymer ratio and amount of cross-linker was increased. The prepared hydrogel dressing showed pH-dependent swelling and swelling was decreased significantly with increase in the concentration of TG and cross-linker. Optimized hydrogel dressing batch HD1 exhibited highest drug loading with non-Fickian drug release. Hydrogel dressings were found to be hemocompatible and exhibited wound healing activity in mice. Conclusion: It can be concluded that the citric acid cross-linked polysaccharide-based hydrogel dressings have potential application in the development of topical drug delivery systems for treatment of the wound.

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Section: Research Articlementioning

confidence: 99%

“…[17] Tamarind polysaccharide is promising excipient, which is being used and investigated for the preparation of various dosage forms. [15,[18][19][20][21][22] The presence of hydroxyl groups in TG makes it suitable for the preparation of physically [23] or chemically [24] cross-linked hydrogels.…”

Section: Research Articlementioning

confidence: 99%

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Mali¹

2018

AJP

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“…The seed comprises of the seed coat or testa (20-30%) and the kernel or endosperm (70-80%). It contains 67.1 g/Kg crude fiber with a higher percentage of carbohydrate in the form of sugars [19] . Tamarind seed is the raw material used in the manufacture of tamarind seed kernel powder (TKP), polysaccharide, adhesive and tannin.…”

Section: Tamarind Gum -A Versatile Natural Polysaccharidementioning

confidence: 99%

“…TG is comparatively cheap, non-irritant, eco-friendly and non-polluting than other semisynthetic or synthetic polymers. Due to its distinct advantageous properties, TG is used as the polymer in the fields of cosmetic and food industry [4,19,21,41] . Recent studies showed that TG forms an excellent hydrogel by physical crosslinking, which makes it suitable for topical drug delivery [42,43] .…”

Section: Chemistry and Properties Of Tamarind Gummentioning

confidence: 99%

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Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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Extraction, Characterization, Biocompatibility, and Antioxidant Activity of Dillenia Indica L. Fruit Polysaccharide

Mohanta,

Sen,

Nayak

2024

Starch Stärke

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The current investigation describes extraction and characterization of aqueous‐soluble polysaccharide (DIFP) from mature Dillenia indica L., fruits to explore its biocompatibility and antioxidant properties (in vitro). In this work, employing the hot‐water extraction method, a whitish brown colored, tasteless, odorless DIFP is extracted (14.45% yield). The findings of the phytochemical identification showed that the extracted DIFP contained both mucilage and carbohydrates. The purity of DIFP is revealed by the examination of three different ash values. 1H NMR spectroscopy, FT‐IR spectroscopy, DSC, and P‐XRD analyses of extracted DIFP are carried out. The results of hemocompatibility (in vitro) experiments, in particular, the determinations of hemolysis percentage (0.80%) and thrombogenicity percentage (5.55%), indicated that the DIFP exhibited nonhemolytic and nonthrombogenic properties. The in vivo acute toxicity evaluation in Swiss Albino male mice clearly presented the absence of any mortality (within 24 h) after intraperitoneal administration of the extracted DIFP (up to 1500 mg kg−1), indicating its nontoxicity, in vivo. Different in vitro tests of antioxidant activity, such as DPPH, ABTS, and hydroxyl radical scavenging, showed a strong antioxidant effect of extracted DIFP. The extracted DIFP (from mature DIFs by hot‐water extraction method) can be used as a natural antioxidant in a variety of applications.

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Tamarind Seed Polysaccharide: An Emerging Excipient for Pharmaceutical Use

Cited by 67 publications

References 41 publications

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Untitled

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Extraction, Characterization, Biocompatibility, and Antioxidant Activity of Dillenia Indica L. Fruit Polysaccharide

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