Talar Osteochondral Defects

Görmeli, Gökay; Ersoy, Yüksel; Görmeli, Cemile Ayşe

doi:10.5455/medscience.2015.04.8255

Cited by 2 publications

(3 citation statements)

References 45 publications

(18 reference statements)

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“…Indeed, at least from the owners' HCPI score side, the results could be attributed to a placebo effect. However, a number of randomized, controlled trials demonstrated variable efficacy of the major treatments (HA, PRP, or NSAIDS) in both dogs and humans [40][41][42][43][53][54][55][56][57][58][59][60][61]. Furthermore, we have additional unpublished data regarding the use of bone marrow-derived MSCS in dogs affected by spontaneous OA where, despite good clinical results, extended culture time, the need for specialized facilities, and high-costs make it more limited compared to MFAT.…”

Section: Discussionmentioning

confidence: 99%

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Zeira

Scaccia

Pettinari

et al. 2018

Stem Cells Translational Medicine

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Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra‐articular delivery of cells (including mesenchymal stromal cells), have been proposed. Among the many sources, the adipose tissue is considered very promising. We evaluated the safety, feasibility, and efficacy of a single intra‐articular injection of autologous and micro‐fragmented adipose tissue (MFAT) in 130 dogs with spontaneous OA. MFAT was obtained using a minimally invasive technique in a closed system and injected in the intra‐ and/or peri‐articular space. Clinical outcomes were determined using orthopedic examination and owners’ scores for up to 6 months. In 78% of the dogs, improvement in the orthopedic score was registered 1 month after treatment and continued gradually up to 6 months when 88% of the dogs improved, 11% did not change, and 1% worsened compared with baseline. Considering the owners’ scores at 6 months, 92% of the dogs significantly improved, 6% improved only slightly, and 2% worsened compared with baseline. No local or systemic major adverse effects were recorded. The results of this study suggest that MFAT injection in dogs with OA is safe, feasible, and beneficial. The procedure is time sparing and cost‐effective. Post injection cytological investigation, together with the clinical evidence, suggests a long‐term pain control role of this treatment. The spontaneous OA dog model has a key role in developing successful treatments for translational medicine. stem cells translational medicine 2018;7:819–828

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Section: Discussionmentioning

confidence: 99%

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Zeira

Scaccia

Pettinari

et al. 2018

Stem Cells Translational Medicine

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“…The chondral lesion is the most common musculoskeletal defect that usually affects old age individuals[43]. Damage affecting chondral and bony part of the joint is called osteochondral defect, when solely articular cartilage is affected the term chondral injury or defect is usually applied[44] [45]. Articular cartilage damage may found isolated, but associated tissues are always involved[46].…”

mentioning

confidence: 99%

“…Ligaments laceration is usually associated with traumatic injuries[52]. Etiology of the osteochondral lesions is also due to other causes rather than trauma such as metabolic defects, ischemia, joint degenerative disease, thromboembolism, corticosteroids or inflammatory diseases[45] [54].…”

mentioning

confidence: 99%

Fabella Syndrome: A Typical Case of Misdiagnosis and Discussion

Alsharif¹,

Almasaad²,

Bakhit³

et al. 2019

CRCM

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Background: Fabella is a natural occurring sesamoid bone, cartilage or a mixture of both that is usually located at the posterolateral corner (PLC) of the knee [1]. Recently the PLC of the knee has been extensively investigated because it is a common site of injuries and diseases [2] [3]. The complexity of PLC anatomy needs to be fully understood because the fabella could be missed diagnosis as an osteochondral defect, osteochondritis dissecans (OCD), calcific tendinitis, or foreign body. We present a case report of fabella syndrome triggered by trauma and also performed a review of literature for the various diagnoses that might be confused with fabella syndrome. Case presentation: A 29-year-old, Sudanese male presented to the trauma center in King Khalid Hospital in KSA, complaining of pain and partial swelling in his left knee joint due to trauma. Fabella was detected in the posterior lateral corner (PLC) of the knee joint embedded in the lateral head of the gastrocnemius muscle. All other pathological conditions were excluded. Conclusion: Fabella is sesamoid bone with variable size, found in the PLC. Commonly if present it causes periodic pain especially in the fully extended knee or it remains asymptomatic. Trauma, surgery, sports or heavy extreme activities may trigger the pain of asymptomatic fabella. Clinicians should consider that pain in the PLC of the knee can result from the presence of the fabella in a condition called fabella syndrome.

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Talar Osteochondral Defects

Cited by 2 publications

References 45 publications

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Fabella Syndrome: A Typical Case of Misdiagnosis and Discussion

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