Take a Second Look: It's Kikuchi’s Disease! A Case Report and Review of Literature

Joean, Oana; Thiele, Thea; Raap, Mieke; Schmidt, Reinhold E.; Stoll, Matthias

doi:10.4081/cp.2018.1095

Cited by 17 publications

(21 citation statements)

References 18 publications

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“…Clinical correlation was important as the histology findings were not entirely specific. For example, Kikuchi’s disease commonly presents with fever in children and findings of necrotizing lymphadenitis with vasculitis are typical [ 8 ]. However, Kikuchi’s disease almost never extends into perinodal tissue as seen in our case [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Multisystem Inflammatory Syndrome in Children Mimicking Acute Appendicitis in a COVID-19 Pandemic Area

Jackson¹,

Chavarria²,

Hacking³

2020

Cureus

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The outbreak of the novel coronavirus (2019-nCoV) began in Wuhan, China and spread rapidly throughout the world. As of now, there have been numerous reports demonstrating clinical, radiological and pathological findings in adults. In children, the disease has essentially been seen as mild and self-limiting. However, more recently, children have been presenting with findings reminiscent of Kawasaki’s disease. And secondary to this, the benign nature of COVID-19 disease in children is beginning to be challenged. This phenomenon is now referred to as multisystem inflammatory syndrome in children (MIS-C). Further understanding the clinical course in MIS-C and its temporal association with coronavirus disease 2019 will be paramount for treatment and public health decision making. This correspondence describes a case of MIS-C with gastrointestinal manifestations mimicking acute appendicitis in a child presenting from a COVID-19 endemic area.

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Section: Discussionmentioning

confidence: 99%

A Case of Multisystem Inflammatory Syndrome in Children Mimicking Acute Appendicitis in a COVID-19 Pandemic Area

Jackson¹,

Chavarria²,

Hacking³

2020

Cureus

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“…1,4 The most common histologic finding is the presence of areas of necrosis and apoptosis which surrounded by CD68 + histiocytes, CD123 + plasmacytoid dendritic cells, and activated CD8 + T-lymphocytes. 7 Also, the absence of neutrophils and eosinophils is an important characteristic in support of the diagnosis. 5,8 Several studies purposed that KFD may be a clinical presentation of lupus lymphadenitis or associated with infectious mononucleosis-like syndromes such as EBV infection.…”

Section: Discussionmentioning

confidence: 93%

“…The diagnosis of KFD is based on histopathologic examination of an involved lymph node biopsy 1,4 . The most common histologic finding is the presence of areas of necrosis and apoptosis which surrounded by CD68 + histiocytes, CD123 + plasmacytoid dendritic cells, and activated CD8 + T‐lymphocytes 7 . Also, the absence of neutrophils and eosinophils is an important characteristic in support of the diagnosis 5,8 .…”

Section: Discussionmentioning

confidence: 99%

COVID‐19 in a case with Kikuchi‐Fujimoto disease

Jaseb

Fard

Rezaei

et al. 2021

Clinical Case Reports

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Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare and self-limiting benign disease. 1 KFD is mostly seen in young adults before the age of 30 years with a female predominance, 2 but in children, it is more common in boys. 1 KFD is typically characterized by cervical lymphadenopathy, fever, and skin rash. 3 The etiology of KFD is still unknown, and it can lead to misdiagnosis with other diseases, including lymphoma, systemic lupus erythematosus, or hematological disorders. 4 Although supportive therapy is usually enough for management of KFD, 2 the misdiagnosis can impose patients to unnecessary diagnostic procedures and treatments. In this study, we present a case of Kikuchi-Fujimoto disease that was also positive for novel coronavirus disease 2019 (COVID-19).

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“…25,26 In our series, 1 patient showed evidence of Kikuchi disease, adding to the few published case studies reporting its incidence in the German population. 27,28 Even focusing on the German population alone, epidemiological shifts can be found across different time periods. For instance, a 1967 study by Matzker 29 analyzed a large series of 1553 cervical lymph node biopsies and found a frequency of malignancy amounting to 20.5%, which is considerably lower than the frequency of malignant disease in the current study (38.6%).…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Yield of Excisional Biopsy in Cervical Lymphadenopathy: A Retrospective Analysis of 158 Biopsies in Adults

et al. 2021

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Objectives: Cervical lymph nodes are the most common site of peripheral lymphadenopathy. The underlying etiologies are usually benign and self-limiting but may include malignancies or other severe life-threatening diseases. The aim of the current study was to investigate the various underlying pathologies of cervical lymphadenopathy as assessed by the diagnostic yield of excisional lymph node biopsies of the neck in a tertiary adult practice. The evaluation was performed in light of previous literature and regional epidemiological patterns. Methods: Retrospective analysis of hospital charts of 158 adult patients who underwent an excisional biopsy for suspected cervical lymphadenopathy at a tertiary referral head and neck service between January 2017 and December 2019. Results: The most common underlying pathology was unspecific and/or reactive lymphadenitis in 44.5% of specimens, followed by malignant disease in 38.6% of cases. An age above 40 years was significantly correlated with an increased likelihood of malignant disease. Lower jugular and posterior triangle lymph nodes showed higher malignancy rates than other groups (100% and 66.7%, respectively). The overall surgical complication rate was 2.5%. Conclusions: The results of the current study serve as an indicator of the variety of etiologies causing cervical lymphadenopathy. In particular, given the increasing incidence of malignant diseases in recent decades, the findings should alert physicians to the importance of lymph node biopsy for excluding malignancy in persistent cervical lymphadenopathy especially in older adults. The findings emphasize the value of excisional lymph node biopsy of the neck as a useful diagnostic tool in adult patients with peripheral lymphadenopathy.

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Take a Second Look: It's Kikuchi’s Disease! A Case Report and Review of Literature

Cited by 17 publications

References 18 publications

A Case of Multisystem Inflammatory Syndrome in Children Mimicking Acute Appendicitis in a COVID-19 Pandemic Area

A Case of Multisystem Inflammatory Syndrome in Children Mimicking Acute Appendicitis in a COVID-19 Pandemic Area

COVID‐19 in a case with Kikuchi‐Fujimoto disease

The Diagnostic Yield of Excisional Biopsy in Cervical Lymphadenopathy: A Retrospective Analysis of 158 Biopsies in Adults

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