Takayasu Arteritis in Major Rheumatology Centers in Malaysia

Khor, Chiew Gek; Tan, Bee Eng; Kan, Sow Lai; Tsang, Esther Ee Ling; Lim, Ai Lee; Chong, Edward; Rachel, Thundyil; Teh, Cheng Lay; Loh, Yet Lin; Ch’ng, Shereen Suyin; D'Souza, B; Mokhtar, Ainon Mohd; Ong, S G; Isa, Liza Mohd

doi:10.1097/rhu.0000000000000362

Cited by 6 publications

(9 citation statements)

References 15 publications

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“…[6][7][8] Approximately half of Asian and Mexican TA patients have RAI. 5,6,11,12 However, RAI could only be detected in about 27% of the Japanese TA patients, which is low compared with other Asian populations. 10,11,13 The prevalence of RAI in our study was 48.90%, which was similar to that reported by Zheng et al 11 Although the prevalence of RAI among Chinese TA patients seems to be high, no study focusing on their characteristics has been conducted.…”

Section: Discussionmentioning

confidence: 95%

“…The prevalence of RAI among TA patients varies from 11.5% to 62%, and seems to be closely related to ethnicity. [5][6][7][8][9][10][11][12] Prevalence of RAI in North America, Northern Europe, and Africa is slightly lower than that in other regions, ranging from 11.5% to 25%. [6][7][8] Approximately half of Asian and Mexican TA patients have RAI.…”

Section: Discussionmentioning

confidence: 99%

“…The reported prevalence ranges from 4% to 77%. [5][6][7][8][9][10][11][12] It is always secondary to renovascular stenosis (RAS). 17 Unilateral or bilateral RAI, especially RAS, will result in the activation of the renin-angiotensin-aldosterone system, which in turn leads to hypertension via vasoconstriction and retention of sodium and water.…”

Section: Discussionmentioning

confidence: 99%

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The renal artery is involved in Chinese Takayasu’s arteritis patients

Chen

Yang

et al. 2018

Kidney International

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The renal artery is involved in Chinese Takayasu’s arteritis patients

Chen

Yang

et al. 2018

Kidney International

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“…However, local abdominal lesions are relatively common in male patients over 40-years-old (13,14). The incidence of TA involvement in the coronary artery was reported in 10-30% of cases (8,15,16). In this study, 442 patients with TA were included, the ratio of male to female was 1:4.5, and the average age of onset was (35.35±13.37) years.…”

Section: Hscpr Esr Biochemical Indexes and Cardiac Functionmentioning

confidence: 82%

A study on the risk factors of coronary artery disease in patients with Takayasu arteritis

Wang¹,

Jia²,

Zhou³

et al. 2020

J Thorac Dis

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Background:The aim of this study was to investigate the risk factors of Takayasu arteritis (TA) involving the coronary artery.Methods: Patients with TA involving coronary artery were included in this study. According to the patients' condition of coronary artery involvement, they were divided into two groups: group A: TA involved coronary artery disease [at least one coronary artery stenosis (≥50%)] and group B: TA did not involve coronary artery. A logistic regression model was used to analyze the risk factors of arteritis involving the patients' coronary artery lesions.Results: A total of 442 TA patients were included in this study. The patients were significantly older in group A than those patients in group B (52.54±11.17 vs. 37.73±12.72, P<0.001). The age of onset in group A was significantly older than those patients in group B (42.21±11.46 vs. 32.74±13.13, P<0.001). The patients in group A had a longer course of disease (P<0.001), larger BMI (P=0.002) and higher rates of smoking, drinking, diabetes, dyslipidemia (P<0.05) when compared with group B. The level of eGFR was significantly decreased and the UA and TG levels were significantly increased in group A when compared with group B(P<0.05). Besides, the risk factors for TA involving coronary artery included the age of TA onset (OR =1.143, 95% CI: 1.007-1.298, P=0.039), course of TA (OR =1.165, 95% CI: 1.025-1.324, P=0.020), and BMI (OR =1.100, 95% CI: 1.021-1.185, P=0.013). Conclusions:The later the age of TA onset, the longer the course of TA onset and the more traditional risk factors associated with atherosclerosis, the more vulnerable patients are to coronary artery involvement and this may not be related to clinical disease activity.

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“…Renal artery is a commonly involved vessel in TAK, although studies in different regions have shown that the proportion of renal artery involvement (RAI) varies. The prevalence of RAI among TAK patients varies from 11.5-62%, but approximately half of Asian and Mexican TAK patients have RAI [4,13,14].…”

Section: Discussionmentioning

confidence: 99%

The performance of duplex ultrasonography for the assessment of renal artery stenosis in Takayasu’s arteritis patients

WANG

Wang

Zhang

et al. 2023

Preprint

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Background: This study intends to analyze the renal artery hemodynamic parameters in Takayasu’s arteritis (TAK) patients, so as to explore the diagnostic value of duplex ultrasonography in the involved renal artery of TAK patients. Methods: 115 TAK patients with 314 renal arteries were retrospectively analyzed, who were admitted to Peking Union Medical College Hospital from 2017 to 2022 and underwent both renal artery ultrasonography and angiography within 4 weeks. Seven ultrasonic parameters were compared among groups with different degrees (noninvolvement, <50% stenosis, 50%-69% stenosis, 70%-99% stenosis) of renal artery stenosis (RAS). Receiver operating characteristic curves (ROCs) were used to obtain the optimal threshold of renal artery PSV (RPSV), the renal-aortic PSV ratio (RAR), and renal-interlobar PSV ratio (RIR) for diagnosing different degrees of RAS in TAK patients. Results: There were statistically significant differences in RAR and RIR among the four groups (all P < 0.05), while there were no statistically significant differences in RPSV and AT between the moderate stenosis group (50%-69% stenosis) and the severe stenosis group (70%-99% stenosis). The discrimination of interlobar PSV(IPSV) and interlobar RI (IRI) was not significant, while IEDV was not statistically significant among the four groups. For TAK patients, the optimal thresholds of RPSV for diagnosing renal artery involvement (RAI), ≥ 50 % RAS and ≥ 70 % RAS were 143cm/s, 152cm/s and 183cm/s, respectively, with the sensitivities, specificities and accuracies all higher than 80%. The optimal thresholds of RIR for detecting RAI, ≥50% RAS and ≥70% RAS are 4.6, 5.6 and 6.4, respectively with satisfied diagnostic efficiencies. The areas under the curve (AUCs) of RPSV and RIR are 0.908 and 0.910 for diagnosing ≥ 50% RAS, and 0.876, 0.882 for diagnosing ≥ 70% RAS. When aortic PSV ≥ 140cm/s, RAR has an unsatisfied diagnostic efficiency and when aortic PSV < 140cm/s, RAR ≥ 2.2 can be used as the diagnostic threshold for ≥ 70 % RAS with a sensitivity, specificity, and overall accuracy of 84.00%, 89.93% and 89.08%, respectively. Conclusion: RPSV and RIR are still most valuable ultrasonic diagnostic parameters for RAS in TAK patients, but the optimal thresholds of them are different from the diagnostic criteria established based on atherosclerotic patients. For RAR, its diagnostic value should be judged according to the degree of aortic stenosis.

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Takayasu Arteritis in Major Rheumatology Centers in Malaysia

Abstract: The Malaysian TAK cohort had similarities with and differences from other published TAK cohort. A nationwide TAK registry is needed to determine the prevalence of the disease among different ethnic groups.

Cited by 6 publications

References 15 publications

The renal artery is involved in Chinese Takayasu’s arteritis patients

The renal artery is involved in Chinese Takayasu’s arteritis patients

A study on the risk factors of coronary artery disease in patients with Takayasu arteritis

The performance of duplex ultrasonography for the assessment of renal artery stenosis in Takayasu’s arteritis patients

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