Tailoring of Au-TiO2 nanoparticles conjugated with doxorubicin for their synergistic response and photodynamic therapy applications

Akram, Muhammad Waseem; Raziq, Fazal; Fakhar-e-Alam, M.; Aziz, Muhammad Hammad; Alimgeer, Khurram Saleem; Atif, M.; Amir, Muhammad Nur Iman; Hanif, Atif; Farooq, W. A.

doi:10.1016/j.jphotochem.2019.112040

Cited by 37 publications

(18 citation statements)

References 39 publications

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“…The synergistic combination of these substances resulted in a photocytotoxicity study in vitro on breast carcinoma cells MCF-7 in cancer-cell viability loss of up to 70%, according to MTT assay. The synergistic response of Au-TiO 2 @DOX via PDT was also confirmed in an in vivo study on the rat model [90]. As the development of gold-titania hybrids, Xu et al elaborated a system of TiO 2 nanotubes, that were functionalized with gold nanoparticles [87].…”

Section: Tio 2 Nanoparticles As a Vehicle For Chemotherapeuticsmentioning

confidence: 83%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

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Section: Tio 2 Nanoparticles As a Vehicle For Chemotherapeuticsmentioning

confidence: 83%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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show abstract

“…The synergistic combination of these substances resulted in photocytotoxicity study in vitro on breast carcinoma cells MCF-7 in cancer-cell viability loss of up to 70% according to MTT assay. The synergistic response of Au-TiO2@DOX via PDT was also confirmed in in vivo study on the rat model [94]. As the development of gold-titania hybrids, Xu et al elaborated a system of TiO2 nanotubes, that were functionalized with gold nanoparticles [88].…”

Section: Pdt and Doxorubicin Delivery Tested On Breast Cancer Cellsmentioning

confidence: 80%

“…TiO2 was grown on UCNPs@SiO2-NH2 NPs from titanium diisopropoxide bis(acetylacetonate); further hydrothermal treatment yielded crystalline structure PDT in cancer treatment mixed with doxorubicin (tested on HeLa cells) [86] diamond-shaped mesoporous [90] UCNPs@mSiO2/TiO2 (30 nm of silica/titania shell thickness) silica coating was synthesized on UCNPs with tetraethylorthosilicate, silylated and reacted with tetrabutyl titanate followed by calcination to yield anatase phase PDT mixed with doxorubicin delivery against HeLa cells) [91] TiO2 (anatase, 10 nm) Au-TiO2 (1-30 nm)…”

Section: Methods Of Synthesismentioning

confidence: 99%

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

Mlynarczyk

et al. 2020

Preprint

101

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Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

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“…Given their shapes, they are classified into Zero-dimensional, onedimensional, and two-dimensional [4]. Recently, some of advanced types of metallic nanomaterials have been applied in pharmaceutical applications such as anti-cancer [5][6][7][8], antimicrobial [9,10] effects. QDs are considered as semi-conductive zero-dimensional nanocrystals with sizes in range of 1-20 nm.…”

Section: Introductionmentioning

confidence: 99%

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

Gholami

Dadmehr

Jelodar

et al. 2020

Mater. Res. Express

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Development of green based synthesis of nanoparticles has been regarded as a novel and safe alternative method compared to conventional methods. Semiconductor cadmium sulfide quantum dots (CdS QDs) possess unique biological and medical applications includes labeling cells, diagnosing of diseases and imaging intercellular events. The present paper reports the biosynthesis of CdS QDs through aqueous extracts of the regenerated hairy roots of Rhaphanus sativus L. as the organic source for both reducing and stabilizing of Cd and S precursor ions. The characterization of synthesized QDs showed maximum absorbance peak of 460 nm and fluorescence spectrum of cadmium sulfide at 530 nm. The results of Transmission Electron Microscope (TEM) and EDS analysis demonstrated that the particles were morphologically spherical with size distribution between 2-7 nm and confirmed presence of CdS QDs. Fourier transform infrared spectroscopy (FT-IR) also showed the active presence of aromatic, amino, and carboxyl groups on the surface of quantum dots. Cytotoxicity effect of the synthesized CdS QDs on two cell lines include MCF-7 breast cancer and AGS gastric cancer were assayed through MTT assay. The results showed significant inhibitory effects of synthesized QDs on treated cells in a dose dependent manner. It was also concluded that CdS QDs had more apoptosis effect on MCF-7 cells rather than AGS cell lines. The obtained results clearly illustrated that the synthesis of CdS quantum dots with standard features would be possible through costeffective, reliable, environmentally friendly and less toxic alternative method compared to chemical and physical processes and the MTT toxicity assay also illustrated the significant apoptotic effects of synthesized CdS QDs on carcinogenesis.

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Tailoring of Au-TiO2 nanoparticles conjugated with doxorubicin for their synergistic response and photodynamic therapy applications

Cited by 37 publications

References 39 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

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Tailoring of Au-TiO2 nanoparticles conjugated with doxorubicin for their synergistic response and photodynamic therapy applications

Cited by 37 publications

References 39 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles &ndash; Prospects and Applications in Medicine

One-pot biosynthesis of CdS quantum dots through in vitro regeneration of hairy roots of Rhaphanus sativus L. And their apoptosis effect on MCF-7 and AGS cancerous human cell lines

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Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine