Tail immersion test for the evaluation of a nociceptive reaction in mice

Ramabadran, K.; Bansinath, M.; Turndorf, Herman; Puig, Margarita M.

doi:10.1016/0160-5402(89)90019-3

Cited by 106 publications

(50 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like aspirin, it demonstrated late onset of antinociceptive effects which lasted beyond the 5th hour post-treatment. The hot plate test is used to distinguish between peripheral and central acting antinociceptive agents [20]. Our results are suggestive of central acting antinociceptive effects of the QI extract.…”

Section: Discussionsupporting

confidence: 60%

“…Indeed, acetic acid-induced writhing test has been associated with increase in the levels of PGE2 and PGF2α in peritoneal fluid, as well as lipoxygenases, so the mechanism of antinociceptive activity of the extract may be linked to cyclooxygenases and/or lipoxygenases [20]. The significant inhibition of writhing reflux exhibited by the extract strongly indicates that QI has peripheral antinociceptive activity mediated through inhibition COX and local peritoneal receptors.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Antinociceptive and anti-inflammatory properties of methanol fruit extract of Quercus incana in rat and mice models

Saeed¹,

Gul²,

Zakiullah³

et al. 2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 96%

Antinociceptive and anti-inflammatory properties of methanol fruit extract of Quercus incana in rat and mice models

Saeed¹,

Gul²,

Zakiullah³

et al. 2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…Qualitative differences among such things as the method of restraint or the type of nociceptive stimuli militate against comparisons of different studies. 7 Investigations of non-barbiturate anaesthetic agents, notably propofol,4 have generally failed to demonstrate hyperalgesia. In spite of the recent interest in the subject, the question of barbiturate or non-barbiturate induced hyperalgesia remains conjectural.…”

Section: On Considbre Que Les Doses Sous-hypotiques De Thiopentone Pomentioning

confidence: 99%

Hyperalgesia during sedation: effects of barbiturates and propofol in the rat

et al. 1995

View full text Add to dashboard Cite

(P < 0.001), pentobarbitone: 27,8% (P = 0,014), mdthohexitone: 24.9% (P = 0,013), propofol: 21,6% (P = 0,006The belief that sub-hypnotic doses of barbiturate agents enhance pain, perception has been a tenet of anaesthetic practice for >30 yr. In 1960, Dundee ~ used tibial pressure analgesimetry to demonstrate a reduction in nociceptive threshold (NT) in humans following low doses of thiopentone or pentobarbitone. Since then, similar actions of barbiturates have been demonstrated in both human 2 and CAN J ANAESTH 1995 / 42:6 / pp 532-40

show abstract

“…Tail flick test is used to determine both centrally acting analgesics (Rambadrane et al, 1989), like morphine (Domer.,1990), and peripherally acting analgesics like NSAIDs' which inhibit cyclooxygenase in peripheral tissues thereby interfering with the mechanism of transduction of primary afferent nociceptors (Fields et al,1987).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antinociceptive Effect of the Ethanolic Extract of Punica Granatum

Saad

Hwi

Quah

2014

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: There are severe adverse effects of analgesic drugs on human body. Extraction of analgesic drugs from natural products has therefore become the prime objective of the study. In this study, we aimed to evaluate the antinociceptive activity of the pomegranate fruit. Materials and Methods: Antinociceptive activity of ethanol pomegranate extract was examined using three models of pain: the writhing test, the hot tail flick test and the plantar test. The ethanolic extract of pomegranate was administered by oral gavages in doses of (100,150 and 200mg/kg, p.o (orally)), for all the tests and compared with aspirin (100mg/kg, p.o.) which was considered as the standard drug. Phytochemical screening and HPLC analysis of the plant species was carried out. Results: In the writhing test, the index of pain inhibition (IPI) was 37% for ethanolic extract of pomegranate (200mg/kg, p.o.), and 59% for aspirin. In the hot tail flick test, the ethanolic extract of pomegranate (200mg/kg, p.o.), has shown significant analgesia reaching its peak at 60 min maximum possible analgesia (MPA), was 24.1% as compared with aspirin 37.5%. Hyperalgesia was successfully induced by the plantar test and the ethanol extract of pomegranate (100,150,200mg/kg, p.o.), reduced the hyperalgesia in a dose dependent manner comparable to aspirin at (100mg/kg, p.o.). HPLC analysis revealed the presence of gallic acid, ellagic acid and Punicalagins A&B. Conclusion:The results demonstrated that ethanol pomegranate extract has an antinociceptive effect that may be related to the presence of identified phytochemicals.

show abstract

Tail immersion test for the evaluation of a nociceptive reaction in mice

Cited by 106 publications

References 27 publications

Antinociceptive and anti-inflammatory properties of methanol fruit extract of <i>Quercus incana</i> in rat and mice models

Antinociceptive and anti-inflammatory properties of methanol fruit extract of <i>Quercus incana</i> in rat and mice models

Hyperalgesia during sedation: effects of barbiturates and propofol in the rat

Evaluation of the Antinociceptive Effect of the Ethanolic Extract of <i>Punica Granatum</i>

Contact Info

Product

Resources

About