Antinociceptive and anti-inflammatory properties of methanol fruit extract of &lt;i&gt;Quercus incana&lt;/i&gt; in rat and mice models

Saeed, Muhammad; Gul, Farzana; Zakiullah, Zakiullah; Gilani, Syed Naeemuddin; Rehman, Yaqoob Ur; Khan, Inamullah; Muhammad, Naveed; Khan, Haroon

doi:10.4314/tjpr.v15i8.14

Cited by 7 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2024; 26(2): e143020. 3 and a Morris water maze assessment on the eighth day (18). All administrations were carried out via intraperitoneal injections.…”

Section: Animals Groupingmentioning

confidence: 99%

Antioxidative Effects of Hydro-Alcoholic Extract and Essential Oil of Quercus brantii Exerts Anti-Depressant-Like Effect and Improvement of Memory Defect in Progesterone-Induced Postpartum Depression in Rats

taghvimi,

kesmati,

Shahriari

et al. 2024

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Depression and memory disorders are known to be associated with increased oxidative stress. There is evidence suggesting that Quercus brantii (Q. brantii) possesses antioxidant properties. Objectives: This study aims to investigate the impact of Q. brantii hydro-alcoholic extract and oil on cognitive dysfunction in a postpartum depression (PPD) model and on oxidant/antioxidant activity in the hippocampus of adult female rats. Methods: Forty-two female Wistar rats (200 - 250 g) were randomly divided into six groups. PPD was induced by chronic intraperitoneal administration (5 days) of progesterone at a dose of 5 mg/kg, and three days after discontinuation, depressive behavior was assessed using a forced swimming test. Simultaneously, Quercus brantii hydro-alcoholic extract (100 mg/kg) and oil (45%) were administered. Spatial memory and locomotor activity were evaluated 24 hours after training using the Morris water maze and open field tests, respectively. The hippocampus tissue of all rats was used to evaluate oxidant-antioxidant factors, Vitamin D, and corticosterone levels. Results: Quercus brantii extract significantly reduced depression (P < 0.05). Treatment with Q. brantii extract and oil improved spatial memory and learning (P < 0.05). The Q. brantii extract increased levels of SOD, GSH, catalase, and vitamin D while decreasing MDA levels; additionally, Q. brantii oil increased SOD and vitamin D levels and decreased MDA levels in the brain (P < 0.05). Conclusions: Quercus brantii extract and oil appear to have beneficial effects on learning and memory impairment in a PPD-induced model, which may be associated with their biochemical effects on the brain.

show abstract

“…2024; 26(2): e143020. 3 and a Morris water maze assessment on the eighth day (18). All administrations were carried out via intraperitoneal injections.…”

Section: Animals Groupingmentioning

confidence: 99%

Antioxidative Effects of Hydro-Alcoholic Extract and Essential Oil of Quercus brantii Exerts Anti-Depressant-Like Effect and Improvement of Memory Defect in Progesterone-Induced Postpartum Depression in Rats

taghvimi,

kesmati,

Shahriari

et al. 2024

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…The injections and all behavioral experiments took place during the light cycle and were performed from 8:00 am to 2:00 pm. Before each injection, oak extract (100mg/kg, dispersed in %0.9 saline) and oak oil (45%) were shaken for 1 min [25]. All components were injected intraperitoneally (i.p.)…”

Section: Animals Groupingmentioning

confidence: 99%

Antidepressant Effect of Hydroalcoholic Extract of Quercus Brantii and Oil of Quercus Brantii on a Rat Model of Postpartum Depression

2023

jjp

View full text Add to dashboard Cite

Background and Objectives One of the most common complications after childbirth is postpartum depression (PPD), a major depressive disorder. The aim of this study was to investigate the effects of the hydroalcoholic extract and oil of Quercus brantii as an experimental model of PPD in rats. Subjects and Methods 42 adult female Wistar rats in six groups were used in this study. All animals received daily progesterone injections at a dose of 5 mg/kg intraperitoneally for 5 consecutive days. A hydroalcoholic extract of Quercus brantii (100mg/kg) and oil (45%) were administered simultaneously with PPD modeling by progesterone withdrawal. On day 8, depressive behavior was then assessed by a forced swim test. To investigate the role of the oxidant-antioxidant system, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and malondialdehyde (MDA) have been assessed after the last injection. Results Statistical analysis showed that progesterone induced significant immobilization in the control group receiving saline (P<0.001) and in the vehicle group receiving sesame oil (P<0.001). The administration of hydroalcoholic oak extract (100 mg/kg) shortened the immobility time compared to the control group (P<0.05). The results of this study show that depression has no effect on locomotor activity. The hydroalcoholic extract of Quercus brantii (100mg/kg) significantly improved depression, decreased MDA and increased SOD. On the other hand, Quercus brantii oil (45%) has no significant effect on depression, but lowers MDA and increases catalase. Conclusion Q. brantii appears to be a natural source of antidepressant compounds that increase antioxidant levels, which is currently being investigated by our group.

show abstract

“…This experiment was performed as portrayed by Saeed et al 2016, with some necessary modi cations. In this experiment male mice were used.…”

Section: Carrageenan Induce Paw Edemamentioning

confidence: 99%

Evaluation of Analgesic and Anti-inflammatory Effects of 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione in Mice

Athar

Niazi

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose: The purpose of the study is to evaluate the analgesic and anti-inflammatory activity of new synthetic compound: 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione and to compare its effects with the available standard drug, diclofenac sodium in mice. Methods: This test compound was evaluated for its anti-nociceptive activity using hot plate and writhing models, while for antiinflammatory activity evaluation, carrageenan and histamine-induced paw edema models were used. Results: In hotplate test, the latency time (in seconds), at 90 minutes of the administered doses (60 and 120 mg/kg) of 5-amino-3- phenyl -1.3.5-thiadiazine-2-thione were 19.5 seconds (p < 0.05) (Mean latency time) and 21.5 seconds (p < 0.01) (Mean latency time) respectively. In writhing test maximum inhibitory effect was demonstrated at a dose of 120 mg/kg with an average of 1.4 (p < 0.001) wriths (this inhibition was more significant) followed by 60 mg/kg (Mean number of wriths = 1.6) (p < 0.001) . The anti-inflammatory effect of the compound for 60 and 120 mg/kg doses was found to be significant and was more significant for 120 mg/kg in both histamine and carrageenan-induced paw edema models. Conclusion: It has been concluded that 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione represents, dose-dependent antinociceptive and anti-inflammatory properties, which are statistically significant. The test compound showed a significant in-vivo peripheral analgesic effect in the writhing test, in comparison to the diclofenac sodium.

show abstract

Antinociceptive and anti-inflammatory properties of methanol fruit extract of <i>Quercus incana</i> in rat and mice models

Cited by 7 publications

References 15 publications

Antioxidative Effects of Hydro-Alcoholic Extract and Essential Oil of Quercus brantii Exerts Anti-Depressant-Like Effect and Improvement of Memory Defect in Progesterone-Induced Postpartum Depression in Rats

Antioxidative Effects of Hydro-Alcoholic Extract and Essential Oil of Quercus brantii Exerts Anti-Depressant-Like Effect and Improvement of Memory Defect in Progesterone-Induced Postpartum Depression in Rats

Antidepressant Effect of Hydroalcoholic Extract of Quercus Brantii and Oil of Quercus Brantii on a Rat Model of Postpartum Depression

Evaluation of Analgesic and Anti-inflammatory Effects of 5-amino-3-phenyl-1,3,5-thiadiazine-2-thione in Mice

Contact Info

Product

Resources

About