2007
DOI: 10.1016/j.jep.2006.09.007
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Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats

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Cited by 55 publications
(42 citation statements)
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References 36 publications
(49 reference statements)
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“…The next year, this group was also reported in vivo the evaluation of AChE inhibitory effects and Fos expression on neuronal activity in the cerebral cortex of the ethanolic extracts from roots of T. divaricata. This extracts showed strong the neuronal activity with the enhancement of Fos expression and AChE inhibitory effects in the cerebral cortex [30]. Moreover, this group was also reported in 2010 for the effects of T. divaricate root extract on β-amyloid25-35 peptides-induced cognitive deficits in mice.…”
Section: Tabernaemontana Crassa Benthmentioning
confidence: 52%
“…The next year, this group was also reported in vivo the evaluation of AChE inhibitory effects and Fos expression on neuronal activity in the cerebral cortex of the ethanolic extracts from roots of T. divaricata. This extracts showed strong the neuronal activity with the enhancement of Fos expression and AChE inhibitory effects in the cerebral cortex [30]. Moreover, this group was also reported in 2010 for the effects of T. divaricate root extract on β-amyloid25-35 peptides-induced cognitive deficits in mice.…”
Section: Tabernaemontana Crassa Benthmentioning
confidence: 52%
“…Among the AChEI found are some indole glucoalkaloids from Chimarrhis turbinate (Rubiaceae) (Cardoso et al 2004); sarpagan type alkaloids from the Haplophyton crooksii (Apocynaceae) (Mroue et al 1996); iboga alkaloids from Tabernaemontana australis (Apocynaceae) (Andrade et al 2005) and vobasinyl-iboga bis-indole alkaloids from T. divaricata (Ingkaninan et al 2006). In fact, a recent article reported the inhibition of cortical AChE activity and the enhancement of neuronal activity of T. divaricata extracts in rats, suggesting that it is a reversible AChE inhibitor and could be beneficial as a novel therapeutic agent for AD (Chattipakorn et al 2007). …”
Section: Introductionmentioning
confidence: 99%
“…The genus Tabernaemontana (Apocynaceae) has been used in traditional rejuvenation remedies, believed to improve memory, or central nervous system stimulant (Chattipakorn et al 2007). It is especially rich in complex mixtures of monoterpenic indole alkaloids and several Brazilian native species have been chemically investigated being good candidates to furnish cholinesterase inhibitory compounds (Batina et al 2000, Batista et al 1996, Bolzani et al 1984, Cardoso and Vilegas 1999, Cardoso et al 1997, 1998, Kato et al 2002, Lemos et al 1996, Marques et al 1996, Medeiros et al 1999, Monnerat et al 2005, Pereira et al 2004, Rattmann et al 2005, Zocoler et al 2005.…”
Section: Introductionmentioning
confidence: 99%
“…In the elevated plus-maze, aqueous extract at 200 mg/kg showed an anxiolytic effect by increasing the time spent on open arms and the percentage of open arm entries, compared to control group [64][65].…”
Section: Coriandrum Sativummentioning
confidence: 99%