Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats

Chattipakorn, Nipon; Pongpanparadorn, Anucha; Pratchayasakul, Wasana; Pongchaidacha, Anchalee; Ingkaninan, Kornkanok

doi:10.1016/j.jep.2006.09.007

Cited by 55 publications

(42 citation statements)

References 36 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The next year, this group was also reported in vivo the evaluation of AChE inhibitory effects and Fos expression on neuronal activity in the cerebral cortex of the ethanolic extracts from roots of T. divaricata. This extracts showed strong the neuronal activity with the enhancement of Fos expression and AChE inhibitory effects in the cerebral cortex [30]. Moreover, this group was also reported in 2010 for the effects of T. divaricate root extract on β-amyloid25-35 peptides-induced cognitive deficits in mice.…”

Section: Tabernaemontana Crassa Benthmentioning

confidence: 52%

A Review on Tabernaemontana spp.: Multipotential Medicinal Plant

Athipornchai

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Plants in the genus Tabernaemontana have been using in Thai and Chinese traditional medicine for the treatment several diseases. The great majority constituents of Tabernaemontana species have already been subjected to isolation and identification of monoterpene indole alkaloids present in their several parts. Many of monoterpene indole alkaloids exhibited a wide array of several activities. The biogenesis, classification, and biological activities of these alkaloids which found in Tabernaemontana plants were discussed in this review and its brings the research up-to-date on the bioactive compounds produced by Tabernaemontana species, directly or indirectly related to human health.

show abstract

Section: Tabernaemontana Crassa Benthmentioning

confidence: 52%

A Review on Tabernaemontana spp.: Multipotential Medicinal Plant

Athipornchai

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Among the AChEI found are some indole glucoalkaloids from Chimarrhis turbinate (Rubiaceae) (Cardoso et al 2004); sarpagan type alkaloids from the Haplophyton crooksii (Apocynaceae) (Mroue et al 1996); iboga alkaloids from Tabernaemontana australis (Apocynaceae) (Andrade et al 2005) and vobasinyl-iboga bis-indole alkaloids from T. divaricata (Ingkaninan et al 2006). In fact, a recent article reported the inhibition of cortical AChE activity and the enhancement of neuronal activity of T. divaricata extracts in rats, suggesting that it is a reversible AChE inhibitor and could be beneficial as a novel therapeutic agent for AD (Chattipakorn et al 2007). …”

Section: Introductionmentioning

confidence: 99%

“…The genus Tabernaemontana (Apocynaceae) has been used in traditional rejuvenation remedies, believed to improve memory, or central nervous system stimulant (Chattipakorn et al 2007). It is especially rich in complex mixtures of monoterpenic indole alkaloids and several Brazilian native species have been chemically investigated being good candidates to furnish cholinesterase inhibitory compounds (Batina et al 2000, Batista et al 1996, Bolzani et al 1984, Cardoso and Vilegas 1999, Cardoso et al 1997, 1998, Kato et al 2002, Lemos et al 1996, Marques et al 1996, Medeiros et al 1999, Monnerat et al 2005, Pereira et al 2004, Rattmann et al 2005, Zocoler et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures

Vieira

Medeiros

Monnerat

et al. 2008

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

The pharmacotherapy for Alzheimer's disease (AD) includes the use of acetylcholinesterase inhibitors (AChEI). Recent investigations for novel AD therapeutic agents from plants suggested that Tabernaemontana genus is a promising source of novel anticholinesterasic indole alkaloids. In this work two fast screening techniques were combined in order to easily identify novel cholinesterase inhibitors (ChEI). Gas chromatography-mass spectrometry (GC-MS) of the less polar alkaloidic fractions obtained from the acid-base extraction of the stalk of T. laeta revealed thirteen monoindole alkaloids, four of them confirmed by co-injection with previously isolated alkaloids. The others were tentatively identified by mass fragmentation analysis. By gas chromatography with flame ionization detection (GC-FID) and using isatin as internal standard, affinisine and voachalotine were determined as major compounds. These fractions and fourteen previously isolated alkaloids, obtained from root bark of T. laeta and T. hystrix were investigated for acetyl (AChE) and butyrylcholinesterase (BuChE) inhibitory activities by the modified Ellman's method in thin layer chromatography (TLC-ChEI). Results showed selective inhibition of the alkaloids heyneanine and N b -methylvoachalotine for BuChE, and 19-epi-isovoacristine for AChE, whereas olivacine, affinisine, ibogamine, affinine, conodurine and hystrixnine inhibited both enzymes. In addition to confirming that monoterpenoid indole alkaloids can be novel therapeutic agents for AD, this is the first report of the ChEI activity of olivacine, a pyridocarbazole alkaloid.

show abstract

“…In the elevated plus-maze, aqueous extract at 200 mg/kg showed an anxiolytic effect by increasing the time spent on open arms and the percentage of open arm entries, compared to control group [64][65].…”

Section: Coriandrum Sativummentioning

confidence: 99%