T3 Toxicosis in an Iodine-Deficient Area

Determinants of serum T4 and T3 at the time of diagnosis in nosological types of thyrotoxicosis: a population-based study

“…Aizawa et al reporting on 536 GD patients also found lower T 3 and T 4 concentrations among elderly patients. Several studies have reported a connection between iodine intake and the prevalence of T 3 and T 4 toxicosis, the former being more prevalent in iodine-deficient areas (4,32) and the latter dominating in areas with a higher iodine intake (33). We found that T 4 was higher in GD and MNTG patients diagnosed in the region with the highest iodine intake.…”

Syndrome of isolated FT3 toxicosis: A pilot study

“…These findings suggest that the frequency of T3 toxicosis is significantly higher in areas of iodine deficiency (Hollander et al, 1972). Studies have shown the persistence of moderate or even severely affected areas of iodine deficite in several countries of Eastern Europe and in Baltic States (Vitti et al, 2001).…”

Closer correlation between serum triiodothyronine and basal metabolic rate during antithyroid drug treatment in patients with graves' disease.

“…However, ATD is known to cause an intrathyroidal iodine deficiency (Studer and Greer, 1967) with the preferential synthesis of MIT rather than DIT (Richards andIngbar, 1959 Slingerland et at., 1959) and, preferential secretion of T3 rather than T4 (Bellabarba et al, 1972;Hollander et al, 1972). Abuid and Larsen (1974) reported that PTU decreased the T3 level more than MMI in the acute phase, since PTU inhibited both pathways for T3 production.…”