T and B Lymphocytes in Patients with Endometriosis

Badawy, Shawky Z.A.; Cuenca, Violeta; Stitzel, Ann E.; Tice, Diane G.

doi:10.1159/000414914

Cited by 27 publications

(35 citation statements)

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“…Previous investigators have reported alterations in 20 lymphocyte subsets among women with endometriosis compared to controls, 15 and it was conceivable that decreased IgG2 production in patients with advanced disease was due to an imbalance in circulating T and/or B cells. However,in agreement with Gleicher et al, 16 we failed to detect any changes in the absolute number or percentages of circulating B cells, helper T cells, or suppressor/cytotoxic T lymphocytes, in patients with advanced endometriosis compared to the other patient groups (Table I) Alternatively, the production of a regulatory cytokine(s) may be decreased in patients with advanced disease.…”

Section: Discussionmentioning

confidence: 99%

Mitogen Induced Production of Polyclonal IgG is Decreased in Women With Severe Endometriosis

Gebel¹,

Braun²,

Rotman³

et al. 1993

American J Rep Immunol

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Since the number of circulating B cells was similar in each patient group studied, the reduced production of IgG2 in patients with stage 3 or 4 disease was not merely due to fewer antibody producing cells in those subjects, and we speculate that the observed decrease in polyclonal IgG2 production among these patients is due to a primary defect. In additional studies, we observed that polyclonal IgG2 production was normal among stage 3 or 4 patients treated with danazol (N = 11), but significantly reduced in patients treated with gonadotropin releasing hormone agonists (N = 8). Although not conclusive, these data suggest that danazol may have the capacity to correct the defective production of polyclonal IgG2 in patients with severe endometriosis.

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Section: Discussionmentioning

confidence: 99%

Mitogen Induced Production of Polyclonal IgG is Decreased in Women With Severe Endometriosis

Gebel¹,

Braun²,

Rotman³

et al. 1993

American J Rep Immunol

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“…The binding of AsnI to hepatic cellular constituents and its longer retention in the body are also contributing factors to account for this difference in potency (17,18). Along with cadmium chloride (CdC12), cupric chloride (CuC12), and Fe-dextran, As111 is one of the most potent elements affecting cytosolic heme and ALAS activity (7,19,20).…”

Section: Discussionmentioning

confidence: 99%

“…Circumstances which increase cellular "free heme" rapidly increase the enzyme activity by converting the remaining inactive apoenzyme to the active heme-containing holoenzyme (5). Conversely, reductions in cellular heme decrease the heme saturation (6,7). The existence of an interrelationship between heme concentration and the activities of ALAS and HO, the rate-limiting enzymes of heme synthesis and catabolism, respectively, has led to the concept of a cellular regulatory "free heme" pool.…”

Section: Introductionmentioning

confidence: 99%

Assesment of arsenic effects on cytosolic heme status using tryptophan pyrrolase as an index

Cebrián

Albores

Connelly

et al. 1988

J. Biochem. Toxicol.

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Acute arsenic (As) administration produced in rat liver a decrease in the heme saturation of tryptophan pyrrolase (TP), accompanied by dose-related increases in 5-aminolevulinate synthetase (ALAS) and heme oxygenase (HO) activities, along with a corresponding decrease in cytochrome P-450 (P-450) concentration. The relationship between heme synthesis and degradation was altered as a result of As treatment. The magnitude of these effects was related to the oxidation state of arsenic, sodium arsenite (AsIII) being more potent than sodium arsenate (AsV). These results support the contention that the heme saturation of TP is sensitive to treatments that modify liver heme concentration. The increase in HO activity produced by As appears to be mediated by a mechanism largely or entirely independent of heme. The main effects of continuous exposure to AsIII were an initial decrease in the heme saturation of TP, which remained constant during the period of treatment, and an initial increase in ALAS activity, which after ten days of exposure dropped somewhat but remained above control values. No significant effects on HO or P-450 concentration were observed. These results were interpreted as indicative that a new balance between heme synthesis and degradation had been reached and that an adaptive response to the subchronic effects of AsIII was taking place.

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“…A postulated autoimmune aetiology of endometriosis derives from reports on increased polyclonal B cell activity, abnormalities in B and T cell functions, familial inheritance (Zondervan et al, 2002;Nothnicik, 2001), high B and T cells counts (Badawy et al, 1987) and reduced NK cells activity (Oosterlynck et al, 1991, Nothnicik, 2001. Moreover, high serum concentrations of IgG, IgA, and IgM autoantibodies (Nothnicik, 2001;Badawy et al, 1987;Gleicher et al, 1987) and antibodies to endometrium (Wild and Shivers, 1985;Grossinkinsky and Halme, 1993) have been described.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, high serum concentrations of IgG, IgA, and IgM autoantibodies (Nothnicik, 2001;Badawy et al, 1987;Gleicher et al, 1987) and antibodies to endometrium (Wild and Shivers, 1985;Grossinkinsky and Halme, 1993) have been described.…”

Section: Introductionmentioning

confidence: 99%

Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE

et al. 2006

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T and B Lymphocytes in Patients with Endometriosis

Cited by 27 publications

References 0 publications

Mitogen Induced Production of Polyclonal IgG is Decreased in Women With Severe Endometriosis

Mitogen Induced Production of Polyclonal IgG is Decreased in Women With Severe Endometriosis

Assesment of arsenic effects on cytosolic heme status using tryptophan pyrrolase as an index

Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE

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