Mitogen Induced Production of Polyclonal IgG is Decreased in Women With Severe Endometriosis

Abstract

Since the number of circulating B cells was similar in each patient group studied, the reduced production of IgG2 in patients with stage 3 or 4 disease was not merely due to fewer antibody producing cells in those subjects, and we speculate that the observed decrease in polyclonal IgG2 production among these patients is due to a primary defect. In additional studies, we observed that polyclonal IgG2 production was normal among stage 3 or 4 patients treated with danazol (N = 11), but significantly reduced in patients treated with gonadotropin releasing hormone agonists (N = 8). Although not conclusive, these data suggest that danazol may have the capacity to correct the defective production of polyclonal IgG2 in patients with severe endometriosis.

Diagnostic Significance of Selected Serum Inflammatory Markers in Women with Advanced Endometriosis

“…The production of immunoglobulins by B lymphocytes is dependent, among other things, on the action of cytokines. Gebel et al [38] documented that in vitro IgG2 production after the stimulation of B lymphocytes was significantly reduced among women with stages III or IV of endometriosis in comparison to the healthy controls [38]. In this study, a similar tendency in values of total serum IgG concentration in stages III and IV of the endometriosis group was observed.…”

Lymphocytes in Endometriosis

“…The increase in serum concentration of soluble CD23, which is produced from activated B lymphocytes, in patients with endometriosis 65 also indicates enhanced activation of B lymphocytes. In contrast, IgG2 production by circulating B cells stimulated with polyclonal B‐cell activators was decreased in women with severe endometriosis, which may imply B‐cell dysfunction in advanced endometriosis 66 …”

O inibidor Btk Ibrutinib limita o desenvolvimento da endometriose em camundongos

“…They also described higher concentration of soluble CD23 in patients with stage I and II endometriosis, suggesting that mild endometriosis may be immunologically more active than severe endometriosis. Gebel et al (1993) findings also agree with this statement as they have reported reduced polyclonal IgG2 production in stage III and IV endometriosis.…”

“…Most studies demonstrated increased number and/or activation of B cells Gleicher et al, 1987;Scheerer et al, 2016), seven studies found no difference Gebel et al, 1993;Nava Loya et al, 1996; and two studies showed decreased number of B cells Gagne et al, 2003).…”

“…Table 1 summarizes the results of 23 studies selected by systematic review of literature concerning the role of B lymphocytes in endometriosis . Gleicher et al, 1987;Gebel et al, 1993;Scheerer et al, 2016;Walankiewicz et al, 2018).…”