Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE

Quaranta, Maria Giovanna; Porpora, Maria Grazia; Mattioli, Benedetta; Giordani, Luciana; Libri, Irene; Ingelido, Anna Maria; Cerenzia, P.; Felice, Alessia Di; Abballe, Annalisa; Felip, Elena De; Viora, Marina

doi:10.1016/j.lfs.2006.01.026

Cited by 39 publications

(27 citation statements)

References 43 publications

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“…In addition, we demonstrated that treatments with antide and TNF-SHARC increased NK cell activity similar to the human studies (Umesaki et al, 1999). Clinical data show reduced NK cell activity in women with endometriosis (Tanaka et al, 1992;Quaranta et al, 2006), which correlates with the severity of the disease (Wilson et al, 1994). Recent studies propose the decreased NK cell activity in women with endometriosis could be due to an increased proportion of NK cells expressing CD94/NKG2A (Galandrini et al, 2008).…”

Section: Discussionsupporting

confidence: 72%

A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis

Altan¹,

Denis²,

Kagan³

et al. 2010

J Pharmacol Exp Ther

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Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) ␣ in the peritoneal cavity. Blocking interaction of TNF␣ with its receptor by the addition of excess TNF␣-binding protein (TBP)-1 (a soluble form of TNF receptor-1) was effective in animal models of endometriosis. Recently, a novel, high-affinity inhibitor of TNF␣, TNF-soluble high-affinity receptor complex (TNF-SHARC), was created by fusing TBP to both the ␣ and ␤ subunits of inactive human chorionic gonadotropin. This dimeric protein was effective in inhibiting collagen-induced arthritis in mice. In the present study, the efficacy of TNF-SHARC in cellular and in vivo models of endometriosis was examined. TBP and TNF-SHARC dose-dependently inhibited TNF␣-induced secretion of interleukin (IL)-6, IL-8, granulocyte macrophage-colony-

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Section: Discussionsupporting

confidence: 72%

A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis

Altan¹,

Denis²,

Kagan³

et al. 2010

J Pharmacol Exp Ther

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“…Kusakabe et al reported that danazol has an effect to induce recruitment of NK cells in mouse uteri (Kusakabe et al 2007). Quaranta et al found that NK cell activity was significantly down-regulated in endometriosis patients (Quaranta et al 2006). These findings have given rise to the NK cell theory of endometriosis, which presupposes that endometriotic cells are natural NK target cells, and that impaired clearance of ectopic endometrium by NK cells in the peritoneal cavity contributes to the development of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Especially for NK cells, there are many reports that NK cells play an important role in the pathogenesis of endometriosis (Oosterlynck et al 1991(Oosterlynck et al , 1992Ho et al 1995;Quaranta et al 2006;Kusakabe et al 2007). For instance, Oosterlynck et al reported that the decrease in NK activity significantly correlated with the severity of the disease (Oosterlynck et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study

et al. 2010

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In this study, we evaluated the efficacy of Lactobacillus gasseri OLL2809 on endometriosis by the randomized, double-blind and placebo-controlled clinical study, especially against pain, which is one of the causative factors to decrease the quality of life. Sixty-six patients clinically diagnosed with endometriosis were enrolled in this study, 62 of which have successfully completed the trial. The tablets containing 100 mg of L. gasseri OLL2809 (active tablet, n = 29) or placebo tablets (n = 33) were ingested once a day for 12 weeks. Visual analog scale (VAS) of pain intensity at the menstrual period and verbal rating scale (VRS) of dysmenorrhea were significantly improved by the ingestion of the active tablets as compared with placebo tablets. There was no significant change of blood examination and biochemical examination of blood in the enrolled patients. Above results show that the tablet containing L. gasseri OLL2809 is effective on endometriosis, especially against menstrual pain and dysmenorrhea. Moreover, it was found that the tablet has no adverse effects. Therefore, it was suggested that the tablet containing L. gaserri OLL2809 contributes to improve the quality of life in the patients with endometriosis.

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“…However, PCDDs and PCBs can interfere with synthesis, function, storage, or metabolism of hormones, bind to estrogen or androgen receptors. Many studies on the possible association between PCB serum levels and endometriosis, although controversial, indicated a slight increase of risk associated to PCB exposure (8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene–environment interaction

Vichi¹,

Medda

Ingelido³

et al. 2012

Fertility and Sterility

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Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE

Cited by 39 publications

References 43 publications

A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis

A Long-Acting Tumor Necrosis Factor α-Binding Protein Demonstrates Activity in Both In Vitro and In Vivo Models of Endometriosis

Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study

Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene–environment interaction

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