Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene–environment interaction

Abstract

The GSTs polymorphisms per se do not increase the risk of developing endometriosis. However, a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk.

Polymorphisms and allele frequencies of glutathione S-transferases A1 and P1 genes in the Polish population

“…In contrast to our results, the frequency of this allele was higher in a Serbian population, reaching 37.6% (Suvakov et al, 2013). The genotype Ile105Ile frequency observed in our study (41.8%) was similar to that determined by Vichi et al (2012) in a healthy Italian population (42%), where this genotype was found to be associated with a higher risk of endometriosis (frequency in cases, 48.6%). Polymorphism I105V was also studied by Burim et al (2004) in the Brazilian population in association with cirrhosis or pancreatitis in alcoholics.…”

Glutathione S- Transferase M1 in the Serum of Patients with Endometriosis

“…In 2012, Vichi et al showed GSTM1 gene polymorphisms with risk of developing endometriosis (Vichi et al, 2012). Ertunc and colleagues in 2005 examined that a member of the family GSTP1 GST is associated with risk of developing endometriosis risk.…”

Polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and endometriosis risk: a meta-analysis

“…The selected study characteristics are listed in Table 1. Of all the studies, 72.2% investigated both GSTM1 and GSTT1 polymorphisms [10][11][12][13][17][18][19][20][22][23][24][25]27], 17.8% concerned only GSTM1 polymorphism [14][15][16]21,26]; eight were carried out in Caucasian subjects [10,12,14,18,[20][21][22][23], 10 in Asian populations [11,13,[15][16][17]19,[24][25][26][27]; and hospital subjects were used as controls in 15 studies whereas general population were controls in 3 studies [20,21,25]; as well as 11 selected cases with mixed revised American Fertility Society (rAFS) stages, 7 with complete advanced rAFS stages (rAFS III/IV) [13,17,19,22,[25][26][27].…”

“…We therefore performed a meta-analysis of all eligible case-control studies to investigate the genetic effects of these polymorphisms and endometriosis risk [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”