Systolic blood pressure, choroidal thickness, and axial length in patients with myopic maculopathy

Hsu, Chih Chien; Chen, Shih‐Jen; Li, An-Fei; Lee, Fenq-Lih

doi:10.1016/j.jcma.2014.06.009

Cited by 17 publications

(13 citation statements)

References 16 publications

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“…12 However, in the present study, we observed no association between SBP and myopic maculopathy, similar to the result of Hsu's study. 21 Further clinical studies are needed to confirm the relationship between blood pressure and myopic maculopathy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of myopic maculopathy: a cross-sectional study in Han and Uygur adults in Xinjiang, China

Chen

Shan

et al. 2020

BMJ Open

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ObjectivesTo estimate the prevalence, ethnic differences and associated risk factors of myopic maculopathy in Han and Uygur adults in Xinjiang, China.Design and settingA cross-sectional study with multistage, stratified cluster sampling method was conducted in Xinjiang, China.ParticipantsA total of 4023 Han and Uygur participants aged 40 years and older were eligible for the study.Outcome measuresThe association between myopic maculopathy and its risk factors was screened using the generalised estimating equation (GEE) model. We also investigated whether ethnic differences exist between Han and Uygur populations affected by myopic maculopathy. Myopic maculopathy was defined in accordance with International Photographic Classification and Grading System for Myopic Maculopathy.ResultsA total of 3044 subjects (5946 eyes) were included in our study (1736 Han and 1308 Uygur individuals). The participants consisted of 1256 (41.3%) men and 1788 (58.7%) women. The average age was 52.2±9.4 years, and the mean spherical equivalent (SE) was −0.18±2.31 dioptre (D). Myopic maculopathy was detected in 198 eyes of 138 participants. The age-adjusted prevalence of myopic maculopathy reached 5.8% (95% CI 4.8 to 6.8). In the GEE model, myopic maculopathy was significantly associated with old age (per year; OR: 1.16; 95% CI 1.13 to 1.19; p<0.001) and myopic SE (per −1 D; OR: 1.48; 95% CI 1.40 to 1.56; p<0.001). No ethnic differences were detected between Han (98, 5.7%) and Uygur population (40, 3.1%) in terms of the prevalence of myopic maculopathy (OR=0.89; 95% CI 0.53 to 1.48; p=0.64). Neither urbanisation (p=0.38) nor the level of education (p=0.92) was associated with myopic maculopathy.ConclusionsA high age-adjusted prevalence of myopic maculopathy was observed in Han and Uygur populations in Xinjiang, China. Old age and high degree of myopic refraction were independent risk factors for myopic maculopathy. No ethnic differences were detected in Han and Uygur populations affected by myopic maculopathy.

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Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of myopic maculopathy: a cross-sectional study in Han and Uygur adults in Xinjiang, China

Chen

Shan

et al. 2020

BMJ Open

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“…Visual abnormalities could result in aberrant neural activity and neural plasticity, which have been demonstrated in some studies [3,4]. High myopia (HM) is also termed "pathological myopia" or "degenerative myopia" and shows a widespread trend toward the development of pathological and degenerative changes in the neurosensory retina, retinal pigment epithelium (RPE), sclera, and choroid and notably, progression to visual impairment [5,6]. This condition also has an elevated rate of ocular complications in the macula, peripheral retina, and optic nerve, and an increase in intraocular pressure (IOP) often accompanies it [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…These findings support the fact that the fundus structure, especially the retina and optic nerve, is closely related to the brain, especially vision-related areas. Some recent studies mainly focused on changes in the orbital cavity [5,[17][18][19], but the pathophysiology and progression of high myopia are still unclear. It is also unknown whether the complicated physiological changes in the brain are involved in the occurrence and development of the disease.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

Chen

Wang

et al. 2020

Neural Plasticity

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Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.

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“…For the environmental factors, the personal physical factors induced by the exogenous factors are directly involved in the pathogenesis [ 18 ]. Age, obesity, high cholesterol, and high blood pressure aggravate the progression of CNV and further contribute to the occurrence of complications [ 19 , 20 ]. Aside from these so-called physical exogenous factors, various genetic factors are also connected to the initiation and progression of CNV.…”

Section: Introductionmentioning

confidence: 99%

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV

Luo

Yan

Zhang

et al. 2018

BioMed Research International

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Choroidal neovascularization (CNV) is a severe eye disease that leads to blindness, especially in the elderly population. Various endogenous and exogenous regulatory factors promote its pathogenesis. However, the detailed molecular biological mechanisms of CNV have not been fully revealed. In this study, by using advanced computational tools, a number of key gene ontology (GO) terms and KEGG pathways were selected for CNV. A total of 29 validated genes associated with CNV and 17,639 nonvalidated genes were encoded based on the features derived from the GO terms and KEGG pathways by using the enrichment theory. The widely accepted feature selection method—maximum relevance and minimum redundancy (mRMR)—was applied to analyze and rank the features. An extensive literature review for the top 45 ranking features was conducted to confirm their close associations with CNV. Identifying the molecular biological mechanisms of CNV as described by the GO terms and KEGG pathways may contribute to improving the understanding of the pathogenesis of CNV.

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Systolic blood pressure, choroidal thickness, and axial length in patients with myopic maculopathy

Abstract: Thinner SFCT and longer axial length are significant risk factors for myopic maculopathy. Unlike previous epidemiological surveys, results of this clinic-based study suggested that systolic blood pressure is not a significant factor for maculopathy.

Cited by 17 publications

References 16 publications

Prevalence and risk factors of myopic maculopathy: a cross-sectional study in Han and Uygur adults in Xinjiang, China

Prevalence and risk factors of myopic maculopathy: a cross-sectional study in Han and Uygur adults in Xinjiang, China

Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

Computational Approach to Investigating Key GO Terms and KEGG Pathways Associated with CNV

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