Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

Abstract

Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.

Non-invasive Diagnosis and Prognosis Values of 3D Pseudocontinuous Arterial Spin Labeling and Optical Coherence Tomography Angiography in Proliferative Diabetic Retinopathy

“…Previous studies (23,24) have demonstrated that vision impairment causes reductions in cerebral BF, as well as functional changes, especially in vision-related areas such as the TL and occipital lobe (OL). However, other studies (25,26) have found increased CBF in visually impaired patients. In our research, the RCP BF had a positive correlation with TL and OL BF at both PLDs.…”

Lateralization Effects on Cerebral Blood Flow in Patients With Unilateral Pulsatile Tinnitus Measured With Arterial Spin Labeling

“…The CBF maps were calculated from the ASL difference images and the reference images using a single-compartment model. The calculation process of CBF has been specifically described in a previous study ( Wang et al, 2020 ). First, the one-step registration method was used to spatially normalize the CBF map of each participant to a PET template in the Montreal Neurological Institute (MNI) space.…”

Ocular Blood Flow Measurements in Diabetic Retinopathy Using 3D Pseudocontinuous Arterial Spin Labeling

“…Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) is a noninvasive imaging modality that uses magnetically labeled blood water as an endogenous tracer to estimate tissue perfusion. 14 ASL allows the quantification of tissue microvascular blood perfusion and provides a large field of view with no depth limitations. 11 Compared to other ASL imaging techniques, such as continuous ASL (cASL) and pulsed ASL (pASL), the pseudocontinuous ASL (pcASL) technique has improved labeling efficiency and a superior intrasubject signal-to-noise ratio (SNR) 14 and is currently recommended clinically.…”

“…Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) is a noninvasive imaging modality that uses magnetically labeled blood water as an endogenous tracer to estimate tissue perfusion 14 . ASL allows the quantification of tissue microvascular blood perfusion and provides a large field of view with no depth limitations 11 .…”

“…14 ASL allows the quantification of tissue microvascular blood perfusion and provides a large field of view with no depth limitations. 11 Compared to other ASL imaging techniques, such as continuous ASL (cASL) and pulsed ASL (pASL), the pseudocontinuous ASL (pcASL) technique has improved labeling efficiency and a superior intrasubject signal-to-noise ratio (SNR) 14 and is currently recommended clinically. 15,16 ASL has shown satisfactory consistency in measuring blood flow compared with dynamic contrast-enhanced (DCE) perfusion in a previous study, 17 and has been widely used in clinical practice.…”