Systemic nontyphoidal Salmonella infection in normal infants in Thailand

Abstract

Systemic NTS infection in normal infants has a variable disease spectrum. Infants 0 to 6 months of age are at high risk for localized infection, especially meningitis.

Invasive Salmonellosis in Urban Thai Children

“…57 The fatality rate for hospitalized invasive salmonellosis (4.8%) in our study is at the lower end of those reported from children in Africa, that is, 4.4%-27% [9][10][11]14 and lower than those previously reported in Thai children (4%-10%). 48,58 Various predictors of fatality have been reported including extreme ages, comorbidities, Salmonella serovars, adequacy of antimicrobial treatment and gastrointestinal symptoms. [58][59][60][61][62][63][64][65] In contrast to existing reports including one from Thailand 48 suggesting that infant age group was among the major risk factors for Salmonella fatality, our results showed that those who died had a median age higher than that of their counterpart.…”

“…48,58 Various predictors of fatality have been reported including extreme ages, comorbidities, Salmonella serovars, adequacy of antimicrobial treatment and gastrointestinal symptoms. [58][59][60][61][62][63][64][65] In contrast to existing reports including one from Thailand 48 suggesting that infant age group was among the major risk factors for Salmonella fatality, our results showed that those who died had a median age higher than that of their counterpart. In addition, infant age group ( <1 year old) was associated with lower fatality rate (adjusted odds ratio of 0.155).…”

Bacteremia in Malawian Children with Severe Malaria: Prevalence, Etiology, HIV Coinfection, and Outcome

“…Presumptive use of antibiotics that are effective against NTS in children with SMA may not have a significant immediate impact on malaria-related mortality but might provide benefit in the prevention of focal disease (such as meningitis) that may follow NTS bacteremia, particularly in young children [25][26][27]. NTS is a common cause of meningitis in Malawian children !2 years of age, and prevalence is highest during the few months after the peak malaria season [28].…”

Preterm delivery and neonatal meningitis due to transplacental acquisition of non-typhoidalSalmonellaserovarmontevideo

“…Transplacental transmission of Salmonella has well been recognised with serious complications such as miscarriage, neonatal sepsis, septic shock and neonatal deaths 8–10. Non-typhoidal salmonellosis infection in newborns has predilection to cause invasive illness including meningitis 11. This may be attributed to relative non-immune competitiveness at this age.…”