“…With the description by Ellis (1949) of the case of a 1-year-old child, showing associated mast-cell lesions of the liver, spleen, lymph nodes, bonemarrow, and other organs, the systemic manifestations began to emerge. These include splenomegaly and hepatosplenomegaly (Touraine, 1939;Bluefarb and Salk, 1954;Reilly et al, 1955;Brodeur and Gardner, 1956), lymphadenopathy (Little, 1905;Gray, 1938;Degos et al, 1952), and osseous lesions (Sagher et al, 1952;Clyman and Rein, 1952;Sagher et al, 1956). Cases are also described in which systemic mast-cell infiltrations are found in association with skin lesions other than urticaria pigmentosa, and there appears to be a series of distinct but related mast-cell disorders differing mainly in the pattern of organ involvement (Sagher, 1956).…”