SYNOPSISThe endometrium of 30 uteruses with myomata was studied at four standard sites. Glandular atrophy over a myoma or opposite a myoma was the most constant finding. At the margin of a myoma hyperplastic glands were frequently found, and distorted, elongated, or dilated glands were present at this site in half of all specimens. Other changes included adenomyosis and the separation of glands by muscle fibres from the basal layer of the endometrium. The coexistence of many of these findings in endometrial curettings can lead to the histological diagnosis of uterine myomata. Two factors, mechanical and hormonal, may be responsible and their mechanisms are discussed.The pathological changes of the endometrium that occur in the presence of uterine leiomyomata ('fibroids') have been studied with special reference to submucous myomata. The recognition of similar changes in endometrial curettings can enable the presence of myomata to be suspected. It has been possible to show that some of the endometrial changes are due to the mechanical presence of a myoma, whilst other abnormalities appear to be the result of hormonal disturbances. Material and MethodsThirty uteruses with myomata, removed by total or subtotal hysterectomy, were examined. The patients' ages ranged between 31 and 54, with an average age of 45 years. Twenty specimens contained multiple submucous, intramural, and subserous myomata; in the remaining 10 there was a single submucous myoma. The changes in the endometrium were recorded in the following four constant areas of each uterus ( Fig. 1): (1) the endometrium overlying a submucous myoma; (2) the endometrium opposite a myoma; (3) the endometrium at the margin of a submucous myoma; (4) the endometrium from the Fig.

Immunomodulation with hydroxychloroquine is safe and appears to offer some efficacy as an intervention in CU.

SYNoPSIS A case of diffuse intravascular clotting associated with a primary brain tumour (oligodendroglioma) is described. The mechanisms of clotting and subsequent fibrinolytic syndromes are discussed with reference to the literature. On the basis of clinical, laboratory, and postmortem findings the possibility of the induction of diffuse intravascular clotting by primary brain tumours is stressed.