Systemic Distribution of Salusin Expression in the Rat

Suzuki, Noriko; Shichiri, Masayoshi; Akashi, Takumi; Sato, Kengo; Sakurada, Maya; Hirono, Yuki; Yoshimoto, Takanobu; Koyama, Takatoshi; Hirata, Yukio

doi:10.1291/hypres.30.1255

Cited by 60 publications

(58 citation statements)

References 9 publications

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“…Further, serum salusin-α levels may be reduced in hypertension, unlike the serum levels of urotensin-II, a similar peptide produced in endothelial cells (7). Modulators for the synthesis, release, and degradation of salusin-α still remain to be elucidated (11). In addition, the influence of antihypertensive drugs on serum salusin-α levels has not yet been determined.…”

Section: Discussionmentioning

confidence: 99%

Serum Salusin-.ALPHA. Levels Are Decreased and Correlated Negatively with Carotid Atherosclerosis in Essential Hypertensive Patients

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Serum Salusin-.ALPHA. Levels Are Decreased and Correlated Negatively with Carotid Atherosclerosis in Essential Hypertensive Patients

et al. 2008

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“…Rabbit anti-salusin b (human) serum was obtained from Bachem (Bubendorf, Switzerland). The function of salusin b in rats was investigated by human salusin b and rabbit anti-salusin b (human) serum because human salusin b has been proved to be highly homologous to the rat salusin b [10,19]. Rabbit anti-salusin b (human) serum was diluted in 0.01 M PBS (1:400) for immunohistochemistry or 5 % goat serum (1:1000) for western blot.…”

Section: Salusin B and Anti-salusin B Serummentioning

confidence: 99%

“…Preprosalusin and its mRNA are widely expressed in both human tissues and rat tissues, including vasculature, central nervous system (CNS), lung and kidney [1][2][3]. Salusin b was also abundantly expressed in the CNS in both human and rats [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…In additional, salusins also stimulate the proliferation of VSMCs, cardiomyocytes and fibroblasts, participate in the formation of atherosclerosis, modulate the intracellular signaling pathways and may be a potential survival factor against serum deprivation-induced myocardial cell death in cardiomyocytes [2,8,9]. Preprosalusin and mRNA have been reported to exist abundantly in the hypothalamus and pituitary [3,4]. Salusin b in the paraventricular nucleus (PVN) increases blood pressure (BP) and sympathetic outflow via vasopressin in hypertensive rats [10].…”

Section: Introductionmentioning

confidence: 99%

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Salusin β Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats

Liu

et al. 2015

Cardiovasc Toxicol

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Salusin β is a newly identified bioactive peptide, which shows peripheral hypotensive, mitogenic and proatherosclerotic effects. The present study was undertaken to investigate the role of salusin β within the nucleus tractus solitarii (NTS) and the underlying mechanism in regulating blood pressure and heart rate (HR) in spontaneously hypertensive rats (SHR). Our results showed that bilateral or unilateral microinjection of salusin β (0.4-40 pmol) into the NTS in SHR decreased mean arterial pressure and HR in a dose-dependent manner. Bilateral microinjection of salusin β (4 pmol) within NTS improved baroreflex sensitivity functions in SHR. Pretreatment with glutamate receptors antagonist kynurenic acid (5 nmol) into the NTS in SHR did not alter the salusin β (4 pmol) induced hypotension and bradycardia. Likewise, bilateral vagotomy also did not alter the salusin β (4 pmol) induced hypotension and bradycardia. However, pretreatment with GABAA receptors agonist muscimol (100 pmol) within the rostral ventrolateral medulla (RVLM) in SHR almost completely abolished the hypotension and bradycardia evoked by intra-NTS salusin β (4 pmol). Our findings suggested that microinjection of salusin β into the NTS produced hypotension and bradycardia, as well as improved baroreflex sensitivity functions, via inhibiting the activities of presympathetic neurons in the RVLM in SHR.

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“…Both are alternative splice products from preprosalusin, the torsion dystonia-related gene (TOR2A) [15]. The presence of preprosalusin in rat stomach tissue is specified in RTq-PCR studies [15,16]. A previous study reported the detection of salusin-α and salusin-β immunoreactivity in the stomach and in the intestines [17].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Tanyeli

Eraslan

Polat

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol. Methods: Thirty-two sprague Dawley male rats were randomly divided into four groups, including eight rats in each group as follows: Group 1: control; Group 2: ethanol 5 mL/kg; Group 3: ethanol 5 mL/kg + 5 nmol/kg salusin-α; Group 4: ethanol 5 mL/kg + 5 nmol/kg salusin-β. Results: The salusin-α level increased at a significant level in the ulcer group formed with ethanol (p < 0.001); the change in the salusin-β level is not significant. As for malondialdehyde (p < 0.05) and myeloperoxidase (p < 0.001), when compared with the control group, tumor necrosis factor-α (p < 0.05) levels increased in the group to which ethanol was applied and decreased significantly with the application of salusins. Levels of GSH and IL-1β did not change at a significant level. In addition, histopathologic analysis demonstrated that, in salusin-administered groups, mucosal injury and caspase-3 expressions were reduced. Conclusions: The suppression of salusin-α and salusin-β on caspase-3 expression by means of their effects on

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Systemic Distribution of Salusin Expression in the Rat

Abstract: Salusin-and salusin-are multifunctional bioactive peptides with hypotensive and bradycardic effects.

Cited by 60 publications

References 9 publications

Serum Salusin-.ALPHA. Levels Are Decreased and Correlated Negatively with Carotid Atherosclerosis in Essential Hypertensive Patients

Serum Salusin-.ALPHA. Levels Are Decreased and Correlated Negatively with Carotid Atherosclerosis in Essential Hypertensive Patients

Salusin β Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

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