Serum Salusin-.ALPHA. Levels Are Decreased and Correlated Negatively with Carotid Atherosclerosis in Essential Hypertensive Patients

Watanabe, Takuya; Suguro, Toshiaki; Sato, Kengo; Koyama, Takatoshi; Nagashima, Masaharu; Kodate, Syuusuke; Hirano, Tsutomu; Adachi, Mitsuru; Shichiri, Masayoshi; Miyazaki, Akira

doi:10.1291/hypres.31.463

Cited by 55 publications

(35 citation statements)

References 17 publications

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“…There was a significant negative correlation between serum salusin-alpha levels and the carotid mean-IMT in all subjects, which was in accordance with previous study. 9 Meanwhile, serum salusin-alpha levels showed significant correlation with the plaque scores. So we speculated that serum salusin-alpha levels might be associated with both initial and advanced atherosclerosis.…”

Section: Salusin-alpha Is Associated With Preclinical Atheroscleroticmentioning

confidence: 95%

“…It was reported that development of atherosclerosis may be accelerated by salusin-beta and suppressed by salusin-alpha via acyl-CoA cholesterol acyltransferase-1(ACAT-1) regulation in acute coronary syndrome. 8 Previous study 9 has shown that serum salusin-alpha levels are decreased and correlated negatively with maximum IMT in essential hypertensive patients.…”

Section: Introductionmentioning

confidence: 97%

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Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension

Wang

et al. 2011

J Hum Hypertens

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Serum salusin-alpha, is decreased in essential hypertension and acute coronary syndrome. The study is aimed to explore whether serum salusin-alpha is associated with atherosclerosis and left ventricular (LV) diastolic dysfunction in essential hypertension. Echocardiography, carotid ultrasonography, brachial-ankle pulse wave velocity (BaPWV) and serum salusin-alpha levels were determined in 60 hypertensive patients (29 with and 31 without carotid plaque) and 30 normotensive controls. Hypertensive patients with plaque, compared with those without plaque or the controls, had the lowest values of salusin-alpha. Then the hypertensive patients were divided into left ventricular hypertrophy (LVH) and non-LVH groups according to the echocardiography. Similarly, hypertensive patients with LVH showed the lowest serum salusinalpha levels. In all subjects, serum salusin-alpha levels were negatively correlated with carotid mean-intimamedia thickness (IMT), BaPWV, left ventricle mass index (LVMI) and E/E 0 (r ¼ À0.488, Po0.001; r ¼ À0.381, Po0.001; r ¼ À0.294, P ¼ 0.006; r ¼ À0.303, P ¼ 0.005; respectively). Serum salusin-alpha levels were independent predictors of BaPWV, carotid strain, carotid distensibility, mean-IMT, LVMI and E 0 /A 0 (b ¼ À0.399, 0.283, 0.237, À0.346, À0.306, 0.469; P ¼ 0.002, 0.031, 0.016, 0.005, 0.012 and 0.001, respectively) in multiple linear regression models. These results suggest that serum salusin-alpha may be associated with atherosclerosis and LV diastolic dysfunction in essential hypertension.

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Section: Salusin-alpha Is Associated With Preclinical Atheroscleroticmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 97%

Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension

Wang

et al. 2011

J Hum Hypertens

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“…Salusins mainly affect the cardiovascular system (5)(6)(7)(8). Salusin-β is the most hypotensive peptide: its infusion rapidly and profoundly decreases blood pressure (BP) and heart rate (5).…”

Section: Introductionmentioning

confidence: 99%

“…Both the formation of macrophage foam cells and the development of atherosclerosis are suppressed by salusin-α (7). Serum salusin-α levels are also reported to be significantly lower in patients with coronary artery disease, and in hypertensive patients in whom the salusin-α level is inversely associated with carotid atherosclerosis (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Serum salusin-α levels in systemic lupus erythematosus and systemic sclerosis

Koca¹,

Özgen²,

Işık³

et al. 2014

Eur J Rheum

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Objective: Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), chronic inflammatory diseases, demonstrate an increased incidence of cardiovascular manifestations and subclinical atherosclerotic disease. Salusin-α is a novel bioactive peptide that suppresses the formation of macrophage foam cells, and its serum level is significantly lower in patients with angiographically proven coronary artery disease. The aims of the study were to assess serum salusin-α level and its potential association with the predictors of atherosclerosis in SLE and SSc. Material and Methods:The study included 20 SLE and 22 SSc patients and 23 healthy controls (HC). All of the participants were female. Tumour necrosis factor-α (TNF-α), IL-6 and salusin-α levels, homeostasis model assessment for insulin resistance (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined.Results: Salusin-α levels were lower and the IMTs were higher in the SLE and SSc groups than in the HC group. The salusin-α level was correlated with neither the disease activity scores nor cytokine levels and IMT in the SLE and SSc groups, although it was correlated with triglyceride level in the SLE group (r=-0.564, p=0.012), and with HOMA-IR index in the HC group (r=0.485, p=0.019). Conclusion:The present preliminary study may support the idea that SSc leads to subclinical atherosclerosis, as in SLE. Moreover, it can be concluded that the decreased salusin-α levels in SLE and SSc may contribute to subclinical atherosclerosis. However, further studies with larger sample size are needed to demonstrate this contribution in SLE and SSc.

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“…1) Watanabe et al reported that the development of atherosclerosis may have been accelerated by salusin-β and suppressed by salusin-α via the regulation of acyl-CoA cholesterol acyltransfease-1 in acute coronary syndrome. 4) They also showed that salusin-α was a useful biomarker, with better sensitivity and specificity for detecting coronary artery disease.…”

mentioning

confidence: 98%