Systemic allergic dermatitis following airborne exposure to 1,2‐benzisothiazolin‐3‐one

Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study

“…We found MI in 91.7% of the paints at a maximum concentration of 142.7 ppm, with no statistical differences between the present data and the 2015 study, in which 93% of paints contained MI at concentrations up to 180.9 ppm . The use of MI in paint has, throughout the last decade, been shown to be a relevant exposure in patients with MI contact allergy, and it is well recognized that MI may evaporate from newly painted walls . Additionally, a large prospective observational study showed, in 2016, that approximately 7% of all patients with MI contact allergy had previously experienced allergic symptoms (dermatitis, rhinitis, and/or conjunctivitis) while in newly painted rooms .…”

Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries

“…All of these paints probably contained MCI/MI, BIT, or other isothiazolinones, but in only a few reports were the paints analysed . In recent years, after the introduction of MI in 2000, several case reports on contact hypersensitivity to MI or other isothiazolinones resulting from exposure to paint have been published . A Danish study described, for the first time, four paint factory workers with MI sensitization and allergic contact dermatitis resulting from direct skin exposure to additives with a 10% MI solution .…”

Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice

“…The increasing number of airborne cases reported, including 44 in a recent series, means that the risk of airborne contamination is now better appreciated. The results of an emission chamber test performed in the laboratory on wall samples treated with two coats of paint showed that MI continued to be emitted in the air for up to 42 days …”