Systematic Screening of Different Surface Modifiers for the Production of Physically Stable Nanosuspensions

Lestari, Maria Lucia Ardhani Dwi; Müller, Rainer H.; Möschwitzer, Jan P.

doi:10.1002/jps.24266

Cited by 70 publications

(25 citation statements)

References 35 publications

(53 reference statements)

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“…The DSPE-PEG NPs showed a narrow size distribution as determined using a particle size analyzer (Figure 2). Additionally, Lestari [14] reported that a nanosystem can maintain long-term stability when its zeta potential is −11.1 mV.…”

Section: Resultsmentioning

confidence: 99%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

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Renal ischemia-reperfusion injury (IRI) is a major complication in clinical practice. However, despite its frequency, effective preventive/treatment strategies for this condition are scarce. Curcumin possesses antioxidant properties and is a promising potential protective agent against renal IRI, but its poor water solubility restricts its application. In this study, we constructed curcumin-carrying distearoylphosphatidylethanolamine-polyethylene glycol nanoparticles (Cur-NPs), and their effect on HK-2 cells exposed to IRI was examined in vitro. Curcumin encapsulated in NPs demonstrated improved water solubility and slowed release. Compared with the IRI and Curcumin groups, Cur-NP groups displayed significantly improved cell viability, downregulated protein expression levels of caspase-3 and Bax, upregulated expression of Bcl-2 protein, increased antioxidant superoxide dismutase level, and reduced apoptotic rate, reactive oxygen species level, and malondialdehyde content. Results clearly showed that Cur-NPs demonstrated good water solubility and slow release, as well as exerted protective effects against oxidative stress in cultured HK-2 cells exposed to IRI.

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Section: Resultsmentioning

confidence: 99%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

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“…Drug nanocrystals can be stabilized by a wide variety of stabilizers, including different polymers, surfactants and mixtures thereof (Lestari et al, 2015;Wu et al, 2011). …”

Section: Discussionmentioning

confidence: 99%

Probing adsorption of DSPE-PEG2000 and DSPE-PEG5000 to the surface of felodipine and griseofulvin nanocrystals

Rydberg

Arteta

Berg

et al. 2016

International Journal of Pharmaceutics

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“…A Z-average less than 500 nm 29) and a PDI less than 0.3 42) were considered as an acceptable critical quality attribute (CQA) for nanocrystal suspension. It is well known that the viscosity affected the particle size of milled products or the success rate of nanocrystal suspension.…”

Section: Dispersing Agent Screening Particle Size Distribution Of Frementioning

confidence: 99%

“…Z-Average less than 500 nm 29) and a PDI less than 0.3 42) were considered as the acceptable CQA for successful nanocrystal and dispersing agent screening. HPC-SSL had the advantages to obtain smaller particle size and showed better stability against JP1/JP2 regardless of polymer type.…”

Section: Wetting Agent Screening Particle Size Distribution Of Freshlmentioning

confidence: 99%

Development of Universal Formulation with Superior Re-dispersion Using Nanocrystal Approach with Simultaneous Identification of API Physicochemical Properties

Fujii

Watano

2019

Chem. Pharm. Bull.

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Universal nanocrystal formulation which can be applied to water-insoluble compounds was proposed and the criteria of its physicochemical properties as an active pharmaceutical ingredients (API) were investigated. Nanocrystal suspension was prepared by a wet-beads milling method. An acceptable Critical Quality Attributes (CQA) of nanocrystal suspension was defined by Z-average less than 500 nm and Polydispersity index (PDI) less than 0.3. Screening studies of dispersing and wetting agents were conducted using three model compounds in different pK a , melting points, etc., to find universal nanocrystal formulation. The effect of four structurally different polymer species (hydroxypropyl cellulose (HPC), hydoroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA)) and their different grades or five different surfactants (docusate sodium (DOSS), sodium lauryl sulfate (SLS), cetyl trimethyl ammonium bromide (CTAB), polysolbate80 (PS80), and polyoxyethylene castor oil (CO-35)) were studied on the redispersion stability. It was found that the combination of 4% (w/v) HPC-SSL and 0.2% (w/v) DOSS was the most robust nanocrystal formulation owing to Z-average less than 200 nm and good re-dispersion stability without aggregates at pH 1.2 and pH 6.8. API physicochemical properties were also identified using ten water-insoluble compounds. Consequently, it was found that solubility (water, pH 1.2 and pH 6.8), molecular weight, hydrogen bonding acceptor and the ratio of log D 7.4 to C Log P were critical factors.

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Systematic Screening of Different Surface Modifiers for the Production of Physically Stable Nanosuspensions

Cited by 70 publications

References 35 publications

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Probing adsorption of DSPE-PEG2000 and DSPE-PEG5000 to the surface of felodipine and griseofulvin nanocrystals

Development of Universal Formulation with Superior Re-dispersion Using Nanocrystal Approach with Simultaneous Identification of API Physicochemical Properties

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