Probing adsorption of DSPE-PEG2000 and DSPE-PEG5000 to the surface of felodipine and griseofulvin nanocrystals

Rydberg, Hanna; Arteta, Marianna Yanez; Berg, Staffan; Lindfors, Lennart; Sigfridsson, Kalle

doi:10.1016/j.ijpharm.2016.06.046

Cited by 19 publications

(3 citation statements)

References 36 publications

(40 reference statements)

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“…They form shield-like hydrophilic layers on the surfaces and prevent protein interaction with the membrane. − The structural difference of the PEG chains, such as length and ratio, was estimated in how it affects the stability of liposomes (see also the Supporting Information text). DSPE-PEG2000 and DSPE-PEG5000, which are specifically used in medical studies, − were prepared to investigate the stabilizing effect of PEG length (Tables and S1). In addition, the PEG mixture of DSPE-PEG2000/DSPE-PEG5000 = 1:1 (mol/mol) (DSPE-PEG2000/5000) was prepared as expected to form a bumpy hydrophilic layer and uniquely affect liposome stability.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Stable Liposome Modified by PEG-Lipid in Natural Seawater

Izumi,

Ji,

Koiwai

et al. 2024

ACS Omega

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This paper describes the stabilization of liposomes using a PEGylated lipid, N-(methylpolyoxyethylene oxycarbonyl)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt (DSPE-PEGs), and the evaluation of the survival rate in natural seawater for future environmental applications. Liposomes in natural seawater were first monitored by confocal microscopy, and the stability was compared among different lengths and the introduction ratio of DSPE-PEGs. The survival rate increased with an increase in the PEG ratio. In addition, the survival rate in different cationic solutions (Na + , K + , Mg 2+ , and Ca 2+ solutions) was studied to estimate the effects of the DSPE-PEG introduction. We propose that these variations in liposome stability are due to the cations, specifically the interaction between the poly(ethylene glycol) (PEG) chains and divalent ions, which contribute to making it difficult for cations to access the lipid membrane. Our studies provide insights into the use of PEG lipids and may offer a promising approach to the fabrication of liposomal molecular robots using different natural environments.

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Section: Methodsmentioning

confidence: 99%

Long-Term Stable Liposome Modified by PEG-Lipid in Natural Seawater

Izumi,

Ji,

Koiwai

et al. 2024

ACS Omega

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“…Such conjugates enhance their targeting ability while maintaining their original advantages. 147 For example, DSPE-PEG2000, which has been approved by the FDA for medical use, is one of the PEGylated lipids that self-assemble into the phospholipid bilayer of exosomes by hydrophobic insertion. 107 Coupling of the membrane-bound molecule DSPE-PEG2000 with hyaluronic acid (HA) and FA enabled targeting of breast cancer cells overexpressing CD44 and FA receptors, respectively.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer

Zheng

Weng

et al. 2022

Biomater. Sci.

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“…Furthermore, the hydrophilic shell -comprising PEG 2000 in DP -could endow mixed micelle systems with long circulation times and passive targeting of the tumor location. 32,33 Therefore, it may be an ideal drug delivery system for the intravenous administration of CK ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Preparation of ginsenoside compound-K mixed micelles with improved retention and antitumor efficacy

Jin

Yang

Cai

2018

IJN

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IntroductionGinsenoside compound K (CK) has effects on cell-cycle regulation, tumor growth inhibition, and apoptosis induction. However, it has limited applications in clinical settings because of its low solubility and poor absorption.MethodsTo overcome these limitations, we aimed to develop a mixed micellar system composed of phosphatidylcholine (PC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine polyethylene glycol 2000 (DSPE PEG 2000; DP). CK encapsulated in PC/DP mixed micelles had enhanced solubility, permeability, and retention effects.ResultsCompared to free CK, the CK PC/DP micellar system exhibited improved anticancer effects in vitro, including cell-cycle arrest, apoptosis, and anti-invasion in human lung carcinoma A549 cells. The significant proapoptotic effect was reflected by increased chromosomal condensation, annexin V/propidium iodide staining, and related protein expression. In vitro cellular uptake and optical mouse imaging in vivo suggested that the improved antitumor effect was caused primarily by enhanced uptake and tumor targeting. Furthermore, an in vivo antitumor efficacy study indicated that the CK mixed micelles significantly inhibited tumor growth, thereby decreasing tumor volume at the end of the experiment as compared with that in the control mice. Histological analysis confirmed the antitumor effect with low toxicity.ConclusionThe PC/DP micellar system was an effective drug delivery system for CK in tumor therapy.

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Probing adsorption of DSPE-PEG2000 and DSPE-PEG5000 to the surface of felodipine and griseofulvin nanocrystals

Cited by 19 publications

References 36 publications

Long-Term Stable Liposome Modified by PEG-Lipid in Natural Seawater

Long-Term Stable Liposome Modified by PEG-Lipid in Natural Seawater

Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer

Preparation of ginsenoside compound-K mixed micelles with improved retention and antitumor efficacy

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