Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Xu, Yong; Hu, Ning; Jiang, Wei; Yuan, Hongfang; Zheng, Donghui

doi:10.18632/oncotarget.13626

Cited by 17 publications

(13 citation statements)

References 38 publications

(36 reference statements)

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“…The decrease in MDA values after the administration of liposomal curcumin was shown by other researchers in oxidative stress conditions induced by experimental renal ischemia. 56 The ability to reduce the NO formation has also been demonstrated in previous studies. 57,58 It has been shown that in brain tissue, the inhibition of inducible nitric oxide synthase can be closely correlated with increasing concentrations of the administered curcuminoids.…”

Section: Discussionsupporting

confidence: 53%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

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BackgroundCurcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways. We aimed to assess the efficacy of liposomal curcumin compared with curcumin solution, when in addition to sumatriptan (ST) treatment, in an experimental migraine model induced with nitroglycerin (NTG) in rats.MethodsSeven groups of 9 rats each were investigated: control group without migraine (1 mL saline solution intraperitoneal injection [ip]), control group with induced migraine, NTG+ST group (ST), NTG+ST+curcumin1 (CC1) group – 1 mg/100 g body weight (bw), NTG+ST+CC2 – 2 mg/100 g bw, NTG+ST+liposomal curcumin1 (lCC1) group – 1 mg/100 g bw, and NTG+ST+lCC2 (lCC2) group – 2 mg/100 g bw. NTG and ST were administered as 1 mL ip NTG | 1 mg/100 g bw and 1 mL ip ST | 1 mg/100 g bw, respectively. Plasma total oxidative stress (TOS), malondialdehyde (MDA), nitric oxide (NOx), thiol levels, as well as total antioxidative capacity (TAC) were assessed. The nociception process was assessed by counting the number of flinches and shakes after the formalin test.ResultsThe plasma TOS, MDA, and NOx levels, as oxidative stress parameters, were significantly decreased in the curcumin-treated groups, especially where curcumin was in liposomal form. The thiol and TAC were also improved by the curcumin treatment, with the best results obtained for the liposomal curcumin. The closest number of flinches and shakes to the control group was obtained for the group treated with liposomal curcumin at a dose of 2 mg/100 g bw.ConclusionLiposomal curcumin in a dose of 2 mg/100 g bw when in addition to ST treatment could be an optimum therapeutic strategy for migraine attacks and could represent a base for future clinical research and application.

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Section: Discussionsupporting

confidence: 53%

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

Bulboacă¹,

Bolboacă²,

Stănescu³

et al. 2018

IJN

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“…Xu et al used curcumin, which has antioxidant properties and is a promising protective agent against renal I/R injury. 56 During myocardial I/R, a large amount of ROS is produced. Lee et al generated H 2 O 2 -responsive polymer NPs and examined their therapeutic effect on myocardial I/R injury by targeting them to the site of ROS overproduction to treat oxidative stress-associated diseases.…”

Section: Antioxidant Properties Of Ps/hpgha Nps In Vitromentioning

confidence: 99%

<p>Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy</p>

Lee¹,

Zan²,

Chen³

et al. 2019

IJN

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Background Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H 2 O 2 and leads to vascular thrombosis, which causes tissue damage. Purpose In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant and antioxidant properties in vascular therapy. Methods Both heparin and glutathione are entrapped on PLGA-stearylamine nanoparticles by layer-by-layer interactions. Results The drug release rate is successfully controlled with only 10.3% of the heparin released after 96 hours. An H 2 O 2 -responsive platform is also developed by combining silk fibroin and horse peroxidase to detect H 2 O 2 in this drug delivery system. Besides, hyaluronic acid was decorated on the surface of nanoparticles to target the human bone marrow mesenchymal stem cells (hBMSCs) for cell therapy. The results of an in vitro study indicate that the nanoparticles could be taken up by hBMSCs within 2 hours and exocytosis occurred 6 hours after cellular uptake. Conclusion We propose that the multifunctional nanoparticles that are formed herein can be effectively delivered to the site of an I/R injury via the hBMSC homing effect. The proposed approach can potentially be used to treat vascular diseases, providing a platform for hBMSCs for the controlled delivery of a wide range of drugs.

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“…Every year, multiple new agents are reported to elicit some nephroprotection in pre-clinical models (e.g. [40][41][42][43][44][45][46][47]), but the proof of their efficacy in human trials is still lacking, and, hence, the unmet need remains.…”

Section: Discussionmentioning

confidence: 99%

The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions

2019

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Kidney ischemia, characterized by insufficient supply of oxygen and nutrients to renal epithelial cells, is the main cause of acute kidney injury and an important contributor to mortality world-wide. Earlier research implicated a G-protein coupled receptor (NK1R) in the death of kidney epithelial cells in ischemia-like conditions. P21-associated kinase 1 (PAK1) is involved in signalling by several G-proteins. We explored the consequences of PAK1 inhibition for cell survival under the conditions of reduced glucose and oxygen. Inhibition of PAK1 by RNA interference, expression of a dominant-negative mutant or treatment with small molecule inhibitors greatly reduced the death of cultured kidney epithelial cells. Similar protection was achieved by treating the cells with inhibitors of MEK1, in agreement with the prior reports on PAK1-MEK1 connection. Concomitant inhibition of NK1R and PAK1 offered no better protection than inhibition of NK1R alone, consistent with the two proteins being members of the same pathway. Furthermore, NK1R, PAK and MEK inhibitors reduced the induction of TRAIL in ischemia-like conditions. Considering the emerging role of TRAIL in ischemia-mediated cell death, this phenomenon may contribute to the protective effects of these small molecules. Our findings support further exploration of PAK and MEK inhibitors as possible agents to avert ischemic kidney injury. ARTICLE HISTORY

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Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Cited by 17 publications

References 38 publications

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats

<p>Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy</p>

The role of PAK1 in the sensitivity of kidney epithelial cells to ischemia-like conditions

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