Systematic review with meta‐analysis: early infant feeding and coeliac disease – update 2015

Szajewska, Hania; Shamir, Raanan; Chmielewska, Anna; Pieścik-Lech, Małgorzata; Auricchio, Renata; Ivarsson, Anneli; Kolaček, Sanja; Koletzko, Sibylle; Korponay-Szabó, Ilma Rita; Mearin, M. Luisa; Ribes-Koninckx, Carmen; Troncone, Riccardo

doi:10.1111/apt.13163

Cited by 105 publications

(99 citation statements)

References 39 publications

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“…РОССИЙСКИЙ ВЕСТНИК ПЕРИНАТОЛОГИИ И ПЕДИАТРИИ, 2017; 62: (6) ROSSIYSKIY VESTNIK PERINATOLOGII I PEDIATRII, 2017; 62: (6) наблюдательных исследованиях, опубликованных до февраля 2015 г., также пришли к выводу, что груд-ное вскармливание, само по себе или во время вве-дения глютена не оказывает профилактического действия на развитие аутоиммунитета, характерного для целиакии, или развитие целиакии в детстве [34]. Обновленные рекомендации, касающиеся сроков введения глютена у младенцев и риска развития це-лиакии в детском возрасте были недавно опублико-ваны ESPGHAN [35].…”

Section: оригинальные статьи в помощь практическому врачуunclassified

Updated European Recommendations on the Introduction of Complementary Food in Children – Subject for Thought

Камалова¹

2017

Ross. vestn. perinatol. pediatr.

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Section: оригинальные статьи в помощь практическому врачуunclassified

Updated European Recommendations on the Introduction of Complementary Food in Children – Subject for Thought

Камалова¹

2017

Ross. vestn. perinatol. pediatr.

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“…However, two recent prospective studies with a high level of scientific evidence have shown that the early or late introduction of gluten and the duration and type of breast feeding do not have a preventive effect on disease development. This goes against the previously posed hypothesis (19)(20)(21)(22). Other retrospective studies have analyzed whether the intake of large amounts of gluten (both when introduced into the diet and during the two first years of life) could increase the risk of developing CD.…”

Section: Introductionmentioning

confidence: 96%

Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned

et al. 2018

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Aim: to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study.Methods: prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1 st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically. Results: twenty-six cases were diagnosed, all had a positive biopsy and serology; 21had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI: 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males.Conclusions: the amount of gluten intake between eleven and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression.

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“…Esses estudos mostraram que a idade em que se introduz glúten na dieta infantil, influenciou a incidência de DC e de ACD, apenas durante os 2 primeiros anos de vida, não se observando incidência e prevalência cumulativas durante a infância (4,5) Uma revisão sistemática que avaliou estudos prospectivos observacionais publicados até fevereiro de 2015, também mostrou que amamentação ou tempo da introdução do glúten não tinha efeito preventivo no desenvolvimento de DC ou de ACD, durante a infância (11).…”

Section: Introductionunclassified

Doença celíaca e introdução do glúten na dieta infantil: avaliação dos riscos e benefícios

Cavinatto

2017

Int J Nutrol

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Instituição de origem -FMUSP Titulação -Mestre e Doutor em Pediatria pela FMUSP Medico do ICr do HCFMUSP e do H. Albert Einstein SPRESUMO Doença celíaca (DC) é uma doença sistêmica, imunomediada, provocada pela ingestão de glúten e que ocorre em indivíduos geneticamente suscetíveis. O risco de indução de DC pela dieta infantil contendo glúten, aplica-se exclusivamente a estes indivíduos, isto é, aqueles que apresentam pelo menos um alelo de risco para essa doença. Como normalmente não se sabe se a criança se enquadra neste critério, no momento da introdução das papinhas de cereais, as recomendações em relação aos riscos e benefícios, decorrentes do modo de introdução de glúten se aplicam para todas elas. Em 2008, o Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) recomendava evitar a introdução de glúten na dieta infantil, antes de 4 meses e após 7 meses de idade, e introduzir glúten enquanto a criança estava sendo amamentada. Novas evidências fizeram a ESPHIGAN revisar estas recomendações. Embora o aleitamento materno deva ser estimulado devido a outros grandes benefícios, nem ao aleitamento materno, nem a introdução de glúten durante a amamentação, parece diminuir o risco de DC na infância. Glúten pode ser introduzido na dieta infantil entre 4 e 12 meses de idade. Dados de estudos observacionais apontam a associação entre quantidade de glúten ingerida e risco de DC. Consumo de grandes quantidades de glúten deve ser evitado nas primeiras semanas, após sua introdução na dieta, bem como durante a infância. A quantidade ideal, entretanto, não está estabelecida.Palavras chaves -Glúten, Doença Celíaca, Nutrição ABSTRACT Celiac disease (CD) is a systemic disease, immune-mediated, caused by the ingestion of gluten.

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Systematic review with meta‐analysis: early infant feeding and coeliac disease – update 2015

Abstract: SUMMARYBackground New evidence emerged on early feeding practices and the risk of coeliac disease.

Cited by 105 publications

References 39 publications

Updated European Recommendations on the Introduction of Complementary Food in Children – Subject for Thought

Updated European Recommendations on the Introduction of Complementary Food in Children – Subject for Thought

Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned

Doença celíaca e introdução do glúten na dieta infantil: avaliação dos riscos e benefícios

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