Systematic review on the effect of chemical compounds on craniofacial development of a zebrafish embryo

Abstract

In past decades, Danio rerio has served as a fish model in various studies including genetics and developmental biology. Recently, this model has gained attention to evaluate several environmental toxicants (i.e., herbicide, pesticide, fungicide, component of a plastic product) which have been known to cause environmental pollution and affect aquatic life. In this review, recent study on craniofacial development of a zebrafish is described. This article discusses the effect of chemical pollutants to the craniofacial development of a zebrafish embryo focusing on articles published from 1995 onwards. Abstract of the prior articles were read and analyzed to determine its significance to be included in the discussions on the effect of these toxicants to the craniofacial and jaws development as well as facial morphology of a zebrafish embryo. From about 630 articles, 38 articles have been selected and included in this systematic review. Many of these toxicants are also apparently harmful to mammalian and human. Therefore, findings that have been demonstrated using zebrafish embryo are deemed useful as a guideline for a necessary action to be taken into consideration to protect human health and to ensure the standard quality of the aquatic environment.

Application of zebrafish in the study of craniomaxillofacial developmental anomalies

“…Karen et al found that after zebrafish embryos were treated with the anesthetic MS222, the jaw joint was subluxed in all larvae (Roddy, Skinner, Brunt, Kague, & Hammond, 2017). Some environmental pollutants, such as metallic elements, nanoparticles, persistent organic pollutants, phthalate esters, bisphenol A, and pesticides, also damage jaw development, which has been well summarized in recent reviews (Huang, Wu, Au, & Wu, 2021; B. Lajis, 2018).…”

Toxic Effects of Paclobutrazol on Developing Organs at Different Exposure Times in Zebrafish

“…This hard structure supports the features of the face and forms a cavity for the brain. Many studies have demonstrated that malformations in the fetal head skeleton can be induced by exposure to toxicants during embryonic stages [19][20][21][22]. Zebrafish develop a simple pattern of early larval cartilages and bones, which is highly conserved among vertebrates [23,24].…”