Synthetische Versuche mit dem Acetessigester

A Kinetic Study of Rubazoic Acid Formation Derived From 4-Amino-1(4-Sulphophenyl) 3-Methyl-2-Pyrazolin-5-One.

“…These H-bonding interactions make Rubazoic acids derivatives as interesting compounds to probe the nature of the proton potential energy profile both in the liquid and solid states. Its formation was at first reported by Knorr 5 in 1887 who obtained it from 4-amino-1-phenyl-3-methyl-2-pyrazolin-5-one using FeCl 3 as an oxidizing agent as represented in Fig. 1.…”

“…Formation of rub-azoic acid from diverse reaction sources have been reported by many workers [6][7][8][9][10][11][12][13][14][15]. Knorr [5] and Michaelis [16] reported that rub-azoic Acid on treatment with a strong solution of NaOH is decomposed to give an open chain product exhibited in Fig. 2.…”

The Condensation of 3-Amino-5-Pyrazolones With Aldehydes Syntheses of 5-Pyrazolonoguanidines

“…The I-esults obtained are recorded in Table I (10) have shown that 3-methyl-1-phenyl-5-pyrazolone, when treated with sodium ethylate, was not transformed into the corresponding hydroxy compound. However, in the present work, when the propylidene derivative was treated with sodium and ethyl alcohol, not only the corresponding hydroxy compound was formed but also ammonia was evolved to yield 3,3'-imino-bis(4-propylidene-l-phenyl-5-pyrazali11-5-01).…”

Selectivity of amidrazones towards activated nitriles – synthesis of new pyrazoles and NMR investigation

“…7 Phenazone (antipyrine), a pyrazolin-5-one, was one of the first synthetic drugs. 8 Phenylbutazone, a pyrazolidinedione, is a very potent anti-inflammatory agent, but its use is now banned in some countries. 9 Later on, many modifications of the pyrazole nucleus were attempted and several compounds have been synthesized for the treatment of different conditions like inflammation, pain, cancer, tuberculosis, and diseases caused by bacteria.…”