A Kinetic Study of Rubazoic Acid Formation Derived From 4-Amino-1(4-Sulphophenyl) 3-Methyl-2-Pyrazolin-5-One.

Hussain, Ghulam; Khan, Shakeel Ahmad; Ahmad, Waqar; Athar, Makshoof; Saleem, Rashid

doi:10.21474/ijar01/3800

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Antioxidant activity of the plant extract in terms of the inhibitory effect on linoleic acid peroxidation was assessed by thiocyanate procedure [23][24][25][26].…”

Section: Ferric Thiocyanate (Ftc) Assaymentioning

confidence: 99%

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Khalid¹,

Shahid²,

Khan³

et al. 2018

Trop. J. Pharm Res

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Purpose: To assess the antioxidant and hepatoprotective activity of the aqueous-methanol extract of Cichorium intybus seeds (C. intybus) against carbon tetrachloride (CCl4)-induced liver toxicity in albino Wistar rats. Method: The seed extract of C. intybus was prepared in aqueous methanol (20:80) via Soxhlet solvent extraction process. CCl4 (0.8 mL/kg) was administered to induce hepatic damage in Wistar rats. The seed extract (100, 250 and 500 mg/kg doses) and a 25 mg/kg dose of silymarin (as standard drug) were administered orally to separate groups of albino Wistar rats for 14 days. Blood samples from the rats were analyzed for biochemical markers for hepatic injury. The tissue samples of the rats were subjected to histopathological studies as well as analyzed for liver antioxidants. Results: The results for biochemical markers revealed that the rats treated with the extract (500 mg/kg dose) showed a maximum elevation of catalase (48.90 µmole of H2O2 consumed/min/mg protein), glutothione peroxidase (22.1 mg GSH consumed/min/mg protein), superoxide dismutase (14.2 units/min/mg protein), and a reduction in glutathione (18.1 µmole of GSH/mg protein). Serum biochemical parameters including serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphate (ALKP), and direct bilirubin were significantly (p < 0.01) increased in the treated groups. Oral administration of different doses of C. intybus seed extract significantly (p < 0.01) protected the hepatic cells from impairment. The biochemical markers and hematological parameters were also normal in extract-treated rats in contrast to the standard (silymarin) and control groups. Conclusion: The results show that C. intybus plant is potential a good natural source of natural hepatoprotective and antioxidants agents.

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“…Antioxidant activity of the plant extract in terms of the inhibitory effect on linoleic acid peroxidation was assessed by thiocyanate procedure [23][24][25][26].…”

Section: Ferric Thiocyanate (Ftc) Assaymentioning

confidence: 99%

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Khalid¹,

Shahid²,

Khan³

et al. 2018

Trop. J. Pharm Res

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“…Results of the current study appear to be in agreement with those reported previously [55,56] . Many literature reports also revealed the metal complexation of ligand and DTC group-dependent antifungal effect [57] . The order of antifungal activity of the compounds was Cu(II)>Zn(II)>Ni(II)>ligand>fluconazole.…”

mentioning

confidence: 99%

Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

Khan¹,

Ahmad²,

Munawar³

et al. 2018

pharmaceutical-sciences

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Khan, et al.: Diphenyldithiocarbamate Complexes Synthesis and Biomedical Application Ni(II), Cu(II) and Zn(II) complexes of diphenyldithiocarbamate have been synthesized with the aim of developing antioxidants, potential antibacterial and antifungal agents. Synthesized metal complexes were characterized by magnetic susceptibility, elemental analysis; conductivity measurements, mass spectra, infrared, ultra violet/visible and nuclear magnetic resonance verified the chemical composition of products. Magnetic susceptibility and spectroscopic studies suggested the predicted geometry of the diphenyldithiocarbamate complexes as octahedral geometry of Ni(II) complex distortion square-planer geometry distorted towards tetrahedral for Cu(II) and Zn(II) complexes. Synthesized metal complexes exhibited remarkable antioxidant potential as compared to standard. Zn(II) complex of diphenyldithiocarbamate exhibited IC 50 of 31.45± 0.31 μM while the standard, butylated hydroxytoluene exhibited IC 50 of 44.67±0.45 μM antioxidant activity. Synthesized metal complexes showed very good antibacterial and antifungal potential against Rhodococcuss, Actinomyces viscosus, Bacillus subtilis, Escherichia coli and the fungi, Aspergillus niger, Aspergillus flavus, Candida and Acetomyceta. It's concluded that synthesized metal complexes showed better antioxidant, antibacterial and antifungal potential as compared to diphenyldithiocarbamate as well as the standard and might turn out to be a valuable treatment of numerous kinds of diseases.

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Synthesis characterization and antibacterial activity of Cr (III), Co (III), Fe (II), Cu (II), Ni (III) complexes of 4-(2-(((2-hydroxy-5-nitrophenyl) diazenyl) (phenyl) methylene) hydrazinyl) benzene sulfonic acid based formazan dyes and their applications on leather

et al. 2018

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A Kinetic Study of Rubazoic Acid Formation Derived From 4-Amino-1(4-Sulphophenyl) 3-Methyl-2-Pyrazolin-5-One.

Cited by 6 publications

References 5 publications

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Synthesis, Spectroscopic Characterization and Biological Evaluation of Ni(II), Cu(II) and Zn(II) Complexes of Diphenyldithiocarbamate

Synthesis characterization and antibacterial activity of Cr (III), Co (III), Fe (II), Cu (II), Ni (III) complexes of 4-(2-(((2-hydroxy-5-nitrophenyl) diazenyl) (phenyl) methylene) hydrazinyl) benzene sulfonic acid based formazan dyes and their applications on leather

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