Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

Abstract

Reaction of dibutyltin dichloride, dimethyltin dichloride, and tributyltin chloride with ligands derived from thiosemicarbazone and semicarbazone leads to the formation of a new series of organotin(IV) complexes of general formula R 2 SnCl 2 ÁL and R 3 SnClÁL (where L ligands derived from the condensation of thiosemicarbazide and semicarbazide with 4-hydroxy-3-methoxybenzaldehyde). The authenticity of these ligands and their metal complexes have been established on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, 1 H NMR, 13 C NMR, 119 Sn NMR, and UV spectral studies. These studies showed that the ligands coordinate to the metal atom in a bidentate. An octahedral structure is proposed for the organotin(IV) complexes. The ligands and its metal complexes are screened for their antimicrobial activities against some Gram-positive and Gram-negative bacteria, and fungus. The studies demonstrated that metalation can increase the antimicrobial activity rather than the free ligands.

Synthesis, Characterization and Antimicrobial Activity of Schiff Base (<i>E</i>)-<i>N</i>-(4-(2-Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes

“…This test was performed using the diffusion agar technique [39]. The sensitivity of a microorganism to antibio-tics and other antimicrobial agents was determined by the assay plates, which were incubated at 28˚C for 2 days (for fungi) and at 37˚C for 1 day (for bacteria).…”

Synthesis and characterization of organotin(IV) semicarbazones: potential precursors for nanosized tin oxide

“…Similarly, in 1:2 complexes of the type [R 2 SnCl 2 Á2LH] (where R = CH 3 or C 4 H 10 ), a sharp singlet appeared in the region -47.6 to -79.2 ppm with a shift difference of about 170.6-216.2 ppm as compared to the starting materials. On the basis of these observed chemical shift differences, it is reasonable to assume that the coordination number of tin in the complexes of the types [R 2 SnCl 2 ÁLH] and [R 2 SnCl 2 Á2LH] is five and six, respectively [24,25].…”

Synthesis, spectral, 3D molecular modeling and antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and amino acids

“…Synthesized compounds were screened for their antibacterial activity against Bacillus cereus (MTCC 0430) and Enterobacter aerogenes (MTCC 2824) at various concentrations 25, 50 and 100 μg by the agar Well Diffusion method [26]. 5 ml aliquot of nutrient broth was inoculated with the test organisms and incubated at 37˚C for 24 hours.…”