Aim: Metal complexes of (E)-N-(4-(thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide (S.TH) Schiff bases derived from sulfacetamide (N-[4-(amino-phenyl) sulfonil] acetamide) and 2-thiophenecarboxaldehyde were synthesized and characterized. Methods and Results: The synthesized compositions have been characterized using different physico-chemical techniques. The investigation included elemental analysis, melting point measurements, proton NMR, UV spectroscopy, FT-IR, magnetic susceptibility, conductance measurements, mass spectral analysis, and inductively coupled plasma mass spectrometry (ICP-MS) for determining the concentrations of metal ions. The measured values for molar conductance indicated that the majority of the prepared complexes were nonelectrolytes. The biological activity of the prepared compositions has been investigated. Conclusion: Spectroscopic studies suggested that most of the complexes were coordinated in a regular octahedral arrangement where S.TH ligand and the central metal atom were coordinated through two N amino azomethine groups (−HC=N−) and two sulfur atoms of S thiophene rings in 2L:1M molar ratio. Complexes have shown a promising activity upon screening for the antibacterial characteristics, and antifungal (Aspergillus fumigates and Candida albicans)

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