Preparation, Characterization and Antimicrobial Activity of Schiff Base of (E) - N - (4-(Thiophen-2-ylmethyleneamino) Phenylsulfonyl) Acetamide Metal Complexes

Abstract

Aim: Metal complexes of (E)-N-(4-(thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide (S.TH) Schiff bases derived from sulfacetamide (N-[4-(amino-phenyl) sulfonil] acetamide) and 2-thiophenecarboxaldehyde were synthesized and characterized. Methods and Results: The synthesized compositions have been characterized using different physico-chemical techniques. The investigation included elemental analysis, melting point measurements, proton NMR, UV spectroscopy, FT-IR, magnetic susceptibility, conductance measurements, mass spectral analysis, and inductively coupled plasma mass spectrometry (ICP-MS) for determining the concentrations of metal ions. The measured values for molar conductance indicated that the majority of the prepared complexes were nonelectrolytes. The biological activity of the prepared compositions has been investigated. Conclusion: Spectroscopic studies suggested that most of the complexes were coordinated in a regular octahedral arrangement where S.TH ligand and the central metal atom were coordinated through two N amino azomethine groups (−HC=N−) and two sulfur atoms of S thiophene rings in 2L:1M molar ratio. Complexes have shown a promising activity upon screening for the antibacterial characteristics, and antifungal (Aspergillus fumigates and Candida albicans)

Synthesis, DFT studies, molecular docking, antimicrobial screening and UV fluorescence studies on ct-DNA for novel Schiff bases of 2-(1-aminobenzyl) benzimidazole

“…These plates were kept for 24 h incubation at 37 °C and the inhibition zone measurements (mm) were done. Experiments were triplicated with DMSO as negative control [30, 31, 32, 33, 34]. The results were compared with Ciprofloxacin sample as a standard (positive control).…”

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

“…and 2thiophenecaroboxaldehyde and also synthesized a series of Ag, Cr, Co, Ni, Cu, and Zn metal complexes. They tried out to establish their antimicrobial activity against pathogenic grampositive, gram-negative, and some fungal species by deploying the agar diffusion technique [51]. All the complexes were found potent to inhibiting the growth of microorganisms.…”

Review: A Recent Review in Applications of Heterocyclic Compounds as Antimicrobial Agent

“…complexes were coordinated in a regular octahedral arrangement where S.TH ligand and the central metal atom were coordinated through two N amino azomethine groups (−HC=N−) and two sulfur atoms of S thiophene rings in 2L:1M molar ratio. Complexes have shown a promising activity on screening for the antibacterial characteristics, and antifungal (Aspergillus fumigates and C. albicans) [60]. A new Schiff base derivative ligand (LI) has been produced by condensed isatin and 2,3-diaminobutane (2:1) molar ratio.…”