Synthesis, spectral, 3D molecular modeling and  antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and  amino acids

Singh, Har Lal; Singh, Jangbhadur

doi:10.4236/ns.2012.43025

Cited by 12 publications

(9 citation statements)

References 41 publications

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“…at the concentrations of 100 μ g/mL by the agar well-diffusion method [29]. An aliquot (5 mL) of nutrient broth was inoculated with the test organisms and incubated at 37°C for 24 h. Sterile nutrient agar plates were also prepared, and holes of 6 mm diameter were cut using a sterile cork borer ensuring proper distribution.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Singh

Singh²,

Mukherjee³

2013

Bioinorganic Chemistry and Applications

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The present work stems from our interest in the synthesis, characterization, and antibacterial evaluation of organosilicon(IV) complexes of a class of amino-acid-based Schiff base which have been prepared by the interaction of ethoxytrimethylsilane with the Schiff bases (N OH) in 1 : 1 molar ratio. These complexes have been characterized by elemental analysis, molar conductance, and spectroscopic studies including electronic IR and NMR (1H, 13C, and 29Si) spectroscopy. The analytical and spectral data suggest trigonal bipyramidal geometry around the silicon atom in the resulting complexes. The ligands and their organosilicon complexes have also been evaluated for in vitro antimicrobial activity against bacteria (Bacillus cereus, Nocardia spp., E. aerogenes, Escherichia coli, Klebsiella spp., and Staphylococcus spp.). The complexes were found to be more potent as compared to the ligands.

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Section: Methodsmentioning

confidence: 99%

Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Singh

Singh²,

Mukherjee³

2013

Bioinorganic Chemistry and Applications

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“…Schiff bases and its organotin(IV) derivatives are acknowledged for presenting antibacterial and antifungal properties (Singh e Singh, 2012). Because of the increasing interest in organotin(IV) compounds as bioactive materials, the synthesis and characterization of tin compounds have been growing in the last decades; especially in association with Schiff bases where an increasing bacterial activity is expected against microorganisms (Nath et al, 2008;Singh and Singh, 2012;Roy et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of Organotin Compounds Derived From Phenolic Schiff Bases

Santos

Maia

2019

jCEC

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Several organotin(IV) derivatives of phenolic Schiff bases were prepared and investigated by spectroscopic methods. These compounds were bioassayed to evaluate their bacterial effect against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Salmonella typhimurium) microorganisms. Dimeric and monomeric compounds were characterized by infrared in solid state. Metallic centers having penta-, hexa-, and heptacoordination were identified by multinuclear NMR (1H, 13C and 119Sn) in solution. The di- and triorganotin(IV) derivatives were also investigated by conductimetric measurements in methanol, elemental analysis and melting point. The bioassay of these tin(IV) compounds showed that the best resulting activity was against S. aureus for the triphenyltin(IV) phenolic Schiff base derivatives, presenting MICs of 1.1 µM (0.6 mg mL-1) and 2.2 µM (1.3 mg mL-1).

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“…In coordination chemistry, isatin derivative and its Schiff bases possess a large number of pharmacological properties including antibacterial (Pandeya and Sriram, 1998;Bacchi et al, 2005;Singh and Singh, 2012), anti-HIV (Pandeya et al, 1999;Jarrahpour et al, 2007;Hakimi et al, 2011), antifungal (Pandeya et al, 2005;Sharma et al, 2011), anticonvulsant (Sridhar et al, 2002;Varma et al, 2004), antituberculosis (Qu et al, 2006;Karali et al, 2007), antileprosy, antileukemic (Fahmi and Singh, 1997), analgesic (Pal et al, 2011), and antianxiety activity because of their specific structural features. Research dealing with Schiffbase metal complexes has broad interest in bioinorganic chemistry, catalysis ( Choudhary et al, 2006), and magnetochemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety

Sharma

Meena

Singh

et al. 2016

Main Group Metal Chemistry

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Sn), and ultraviolet-visible light spectroscopic studies. The spectroscopic data showed that the ligands are monobasic bidentate, coordinating through nitrogen and sulfur/oxygen atoms. Thus, suitable trigonal bipyramidal geometry and octahedral geometry have been suggested for the 1:1, and 1:2 metal complexes, respectively. The ligands and their complexes have been tested against various microbes for their in vitro antimicrobial activities. All complexes exhibit good antibacterial activity against the two bacterial species Escherichia coli and Staphylococcus aureus and remarkable antifungal activity against the two fungi Fusarium semitectum and Aspergillus flavus with respect to their corresponding ligands. The DNA cleavage efficiency of the ligands and the complexes has also been examined and discussed using gel electrophoresis technique, which showed the cleavage of DNA by all the metal complexes and ligands.

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Synthesis, spectral, 3D molecular modeling and antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and amino acids

Abstract: ABSTRACT

Cited by 12 publications

References 41 publications

Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Antimicrobial Effect of Organotin Compounds Derived From Phenolic Schiff Bases

Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety

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